What happens in the Lab: Applying Midstream Modulation to Enhance Critical Reflection in the Laboratory

In response to widespread policy prescriptions for responsible innovation, social scientists and engineering ethicists, among others, have sought to engage natural scientists and engineers at the ‘midstream’: building interdisciplinary collaborations to integrate social and ethical considerations with research and development processes. Two ‘laboratory engagement studies’ have explored how applying the framework of midstream modulation could enhance the reflections of natural scientists on the socio-ethical context of their work. The results of these interdisciplinary collaborations confirm the utility of midstream modulation in encouraging both first- and second-order reflective learning. The potential for second-order reflective learning, in which underlying value systems become the object of reflection, is particularly significant with respect to addressing social responsibility in research practices. Midstream modulation served to render the socio-ethical context of research visible in the laboratory and helped enable research participants to more critically reflect on this broader context. While lab-based collaborations would benefit from being carried out in concert with activities at institutional and policy levels, midstream modulation could prove a valuable asset in the toolbox of interdisciplinary methods aimed at responsible innovation

(Re)Conceptualizing decision-making tools in a risk governance framework for emerging technologies—the case of nanomaterials

The utility of decision-making tools for the risk governance of nanotechnology is at the core of this paper. Those working in nanotechnology risk management have been prolific in creating such tools, many derived from European FP7 and H2020-funded projects. What is less clear is how such tools might assist the overarching ambition of creating a fair system of risk governance. In this paper, we reflect upon the role that tools might and should play in any system of risk governance. With many tools designed for the risk governance of this emerging technology falling into disuse, this paper provides an overview of extant tools and addresses their potential shortcomings. We also posit the need for a data readiness tool. With the EUs NMP13 family of research consortia about to report to the Commission on ways forward in terms of risk governance of this domain, this is a timely intervention on an important element of any risk governance system

Coronary microvascular resistance: methods for its quantification in humans

Coronary microvascular dysfunction is a topic that has recently gained considerable interest in the medical community owing to the growing awareness that microvascular dysfunction occurs in a number of myocardial disease states and has important prognostic implications. With this growing awareness, comes the desire to accurately assess the functional capacity of the coronary microcirculation for diagnostic purposes as well as to monitor the effects of therapeutic interventions that are targeted at reversing the extent of coronary microvascular dysfunction. Measurements of coronary microvascular resistance play a pivotal role in achieving that goal and several invasive and noninvasive methods have been developed for its quantification. This review is intended to provide an update pertaining to the methodology of these different imaging techniques, including the discussion of their strengths and weaknesses

Social Responsibility in Research Practice: Engaging applied scientists with the socio-ethical context of their work

How to encourage researchers to critically reflect on the ethical and social dimensions of their work? That is the central research question of this thesis. It starts from the assumption that the neutrality view of the social responsibility of the researcher – the view that researchers have no business with the social and ethical dimensions of their work – has become untenable, at least as far as applied sciences such as nano- and biotechnology are concerned. Instead, this thesis adopts a broader view, arguing that the social responsibility of researchers includes a moral responsibility to critically reflect on the socio-ethical context of their work. While this normative viewpoint itself is not uncommon, the neutrality view remains a dominant frame of reference in daily research practice. The specific contribution this thesis aims to make to the ongoing debate is to ‘revalue value-free science’: by way of three case studies (the implementation of a code of conduct for scientific practice, interdisciplinary collaborations between social and natural scientists, and the development of ‘science and society’ education), it explores opportunities and constraints for realising a broadened conception of social responsibility in daily research practice.Department of BiotechnologyApplied Science

Embedding Nutrigenomics into Nutrition Science. Addressing Epistemological and Social Challenges : valorisation report

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