Control de calidad de residuos de biocidas en frutos de Silybum marianum L.

Analytical studies of organochlorine biocides show that their concentration in the plants (roots) is higherthan in the ground and particularly in the medicinal plants used in the therapy and the pharmacyindustry. The most favorite Bulgarian drugs (Carsil, Tribestan and Nivalin) contain plant extracts andthey have to be analyzed in respect to European Community Directives EEC/76/895 and EEC/90/6421998;In view of that the gas chromatography method for quantitative determination of organochlorine biocides(HCH and isomers, DDT and metabolites) was studied. Plant material from different regions of Bulgaria(fructus from Silybum marianum, L) and Carsil dragee produced by Sopharma Ltd. were analyzed inrespect to European Pharmacopoeia regulations. The method was validated and analytical parametersspecificity, linearity, precision, repeatability and range were studied.Los estudios analíticos de los biocidas organoclorados demuestran que su nivel de concentración en lasraíces de plantas es mayor que la concentración en el suelo, y especialmente en las plantas medicinalesutilizadas en las industrias farmacéutica y medicinal. Los fármacos búlgaros más utilizados (Carsil,Tribestan y Nivalin) contienen extractos de plantas y deben ser analizados de acuerdo con las directivasde la Comunidad Europea EEC/76/895 y EEC/90/642 1998;Por ello, se ha estudiado el método de cromatografía de gases para la determinación cuantitativa debiocidas organoclorados (HCH e isómeros, DDT y metabolitos). Se han analizado conforme a lasregulaciones de la Pharmacopoeia Europea materiales procedentes de plantas de distintas regiones deBulgaria (frutos de Silybum marianum, L) y grageas de Carsil producidas por Sopharma Ltd. El métodoha sido validado y se han estudiado parámetros analíticos de especificidad, linealidad, precisión, replicabilidady rango

VITREOPUPILLARY BLOCK AFTER INTRACAPSULAR CATARACT EXTRACTION

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ULTRASONIC EFFECT ON STAPHYLOCOCCUS CULTURES

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AMYLASE ACTIVТY IN ТНЕ BLOOD AND PANCREAS OF HYPOPHYSECTOMIZED AND TESTOSTERONEPROPIONATE TREATED MALE ALBINO RATS

The activity of sex hormones is subjected to complex neuro-humoraf regulation, with the participation of the brain cortex, subcortex and more particularly of the centers in the hypothalamus, gonadotropic hormones of the adenohypophysis and interaction with other endocrine glands.In previous studies the authors of the present paper have established the activying effect of the testosteronepropionate оn the amylase in blооd and pancreas of male rats. We also established the essential role for its effect played bу the functional condition of the central nervous system, finding moreover that during аn inhibltion process this activying effect is not manifested, whereas during excitation of the central nervous system with coffeine the activying effect is enhanced.The final goal of the present work is to elucidate the role played bу the hypothalamo-hypophyseal system insofar action of male sex hormones is concerned on enzymic activity. With this purpose in view we carried out investigations on the amylase of rats deprived of the hypophysis and hypophysectomized, treated in addition with testosteronepropionate

THE EFFECT OF HIGH DOSES VITAMIN A (100 000 IU) ON THE ACTIVITY OF ACID HEPATIC PHOSPHATASE (ß-GLYCEROPHOSPHATE PHOSPHATASE) IN NORMAL, HEMITHYROIDECTOMIZED AND TREATED WITH EXTRACT OF THE THYROID MALE ALBINO RATS

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INVESTIGATIONS ON THE INFLUENCE OF TESTOSTERONE PROPIONATE VERSUS ACTIVITY OF 5-NUCLEOTIDASE AND ADENYLPYROPHOSPHATASE IN THE AORTIC WALL OF NORMAL AND THYROIDECTOMIZED MALE ALBINO RATS

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AMMOS: A Software Platform to Assist in silico Screening

Three software packages based on the common platform of AMMOS (Automated Molecular Mechanics Optimization tool for in silico Screening) for assisting virtual ligand screening purposes have been recently developed. DG-AMMOS allows generation of 3D conformations of small molecules using distance geometry and molecular mechanics optimization. AMMOS_SmallMol is a package for structural refinement of compound collections that can be used prior to docking experiments. AMMOS_ProtLig is a package for energy minimization of protein-ligand complexes. It performs an automatic procedure for molecular mechanics minimization at different levels of flexibility - from rigid to fully flexible structures of both the ligand and the receptor. The packages have been tested on small molecules with a high structural diversity and proteins binding sites of completely different geometries and physicochemical properties. The platform is developed as an open source software and can be used in a broad range of in silico drug design studies

ON THE INCIDENCE OF THE DIFFERENT FORMS OF PRIMARY GLAUCOMA

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On the parasites of genus Angiostrongylus (Nematoda: Angiostrongylidae) and some cases of Angiostrongylus daskalovi in badgers from bulgaria

In the course of studies on filariid infections in wild carnivorous in Bulgaria nematodes of genus Angiostrongylus were found in the heart and pulmonary arteries of badgers. The detected specimens were examined morphologically and metrically, which allowed us to identify them as Angiostrongylusdaskalovi . A morphometrical description of the species is given in accordance with the present materials.В ходе исследования филариидных инвазий в Болгарии в сердце и легочных артериях барсуков обнаружены нематоды рода Angiostrongylus . Эти образцы исследовались морфологически и метрически, что позволило, с учетом также географического и гостального распространения, идентифицировать их как Angiostrongylus daskalovi Janchev et Genov 1988. Приводится морфометрическое описание вида по данным текущих исследований