12 research outputs found
Metagenomic insights into taxonomic and functional shifts under chronic exposure to hypobaric hypoxia induced microbial communities
Temporal dynamics of gut microbiota in caged laying hens: a field observation from hatching to end of lay
Spatio-temporal variability of chlorophyll a and its responses to sea surface temperature, winds and height anomaly in the western South China Sea
Propionate supplementation promotes the expansion of peripheral regulatory T-Cells in patients with end-stage renal disease
Patients with end-stage renal disease (ESRD) suffer from a progressively increasing low-grade systemic inflammation, which is associated with higher morbidity and mortality. Regulatory T cells (Tregs) play an important role in regulation of the inflammatory process. Previously, it has been demonstrated that short-chain fatty acids reduce inflammation in the central nervous system in a murine model of multiple sclerosis through an increase in tissue infiltrating Tregs. Here, we evaluated the effect of the short-chain fatty acid propionate on the chronic inflammatory state and T-cell composition in ESRD patients. Analyzing ESRD patients and healthy blood donors before, during, and 60 days after the propionate supplementation by multiparametric flow cytometry we observed a gradual and significant expansion in the frequencies of CD2