4 research outputs found
The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells
Waldenstrom's macroglobulinemia developing in a patient with multiple sclerosis: coincidence or association?
Multiple sclerosis ( MS) has been reported in association with
haematological abnormalities, including monoclonal gammopathies. We
present a 54-year-old male patient with a 30-year history of MS who was
admitted to our hospital for investigation of anaemia and increased
erythrocyte sedimentation rate. A monoclonal IgM protein was detected by
serum protein immunofixation, while bone marrow biopsy indicated a 70%
infiltration by small lymphoplasmacytoid cells, in the context of a
lymphoplasmacytoid immunocytoma, findings compatible to the diagnosis of
Waldenstrom’s macroglobulinemia (WM). To our knowledge, this is the
first report of WM in a patient with MS. Further to the coexistence of
the two diseases observed in the case presented here, there is
additional evidence suggesting that the association of MS with plasma
cell dyscrasias may not be coincidental