Impact in hospitalization costs of a cardiovascular risk management program in Colombia: a propensity score matching model

Cardiovascular diseases (CVD) are the leading cause of death and burden of disease in Colombia and globally. In 2017, CVD represented the 12% of total DALYs. CVD is a costly disease from patient, family and societal perspectives. Effective prevention and risk management programs reduces the incidence of CVD by as much as 80%. We aimed to estimate the impact of direct medical hospitalization costs related to adherence in a risk management program in Colombia, 2018. We retrospectively collected data from 6,243 patients with data of enrollment in a cardiovascular risk management program (DTC, in Spanish) of a subsidized insurer, who presented arterial hypertension (AH) or AH+ type 2 diabetes mellitus (DM2). 1,065 were identified adherent to the program (treated) and 5.178 non adherent (controls). We designed a propensity score matching model adjusted with confounding variables to estimate the effect of treatment (program adherence) over hospitalization cost. Costs were calculated based on hospitalization invoices and expressed in Colombian pesos (COP) 2018. DTC has an average negative effect on cost of treated population. Being treated avoids hospitalization costs; these results were statistically significant at the 5% and 10% level (with 95%CI that goes through zero). Hence, being in the DTC program reduces hospital costs that ranges from COP-$11,346,372 to -$ 799,259 (95%CI) compared to the average cost. The overall impact on program costs is a significant saving of COP583,670 per event-year. If all members of the DTC program fulfilled its activities by more than 80%, the savings generated by the program would be close to COP$ 6.85 billion. DTC risk management program reduces direct hospitalization costs of events associated to CVD. Our results are important to design policies focused on the cost and risk management of patients with CVD in poor population

Adherence to long-acting reversible contraceptive methods in low- income young women from the caribbean region of Colombia

Adolescent pregnancies are more likely to occur in poor communities, commonly driven by lack of education and employment opportunities. We aimed to estimate the subdermal implant discontinuation rate and to establish the factors associated with the discontinuation of long-acting reversible contraceptive (LARC) methods in a cohort of poor women in the Caribbean region of Colombia. A retrospective cohort study of LARC method use through review of administrative record data was conducted. A population of 2,192 adolescents and young women between 10-24 years old enrolled in the “SER JOVEN” program and who received subdermal implants between 2015-2018 was considered for eligibility. This program is for young people affiliated to a health care company in the Caribbean region of Colombia. We realized a follow-up time-person of the retrospective cohort, and we estimated the incidence of discontinuation of the subdermal implant at six months, one year, two years, and three years. Kaplan-Meier estimator for survival curves, and Cox proportional hazard model were used to ascertain factors associated with method discontinuation risk. A p-value <0.050 was considered significant. A total of 2,192 women were selected with a mean (standard deviation -SD) age of 19.4 (2.8) years and a mean duration of use of subdermal implant of 2.6 (0.8) years. We estimated the subdermal implant discontinuation rate at six months in 0.7% [CI95% 0.3-1.1], a year later in 1.5% [CI95% 1-2], two years later in 2.1% [CI95% 1.5-2.7] and finally at three years in 2.2% [CI95% 1.6-2.8]. Women who stated they have children at baseline were about 70% less risk to discontinue subdermal implants (HR: 0.3 [CI95% 0.1 – 0.8]). Adolescent pregnancy is a public health problem, and it is an important cause of poverty and illness. Then, the use of subdermal implants is an effective alternative to prevent unintended pregnancies

4to. Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad. Memoria académica

Este volumen acoge la memoria académica de la Cuarta edición del Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad, CITIS 2017, desarrollado entre el 29 de noviembre y el 1 de diciembre de 2017 y organizado por la Universidad Politécnica Salesiana (UPS) en su sede de Guayaquil. El Congreso ofreció un espacio para la presentación, difusión e intercambio de importantes investigaciones nacionales e internacionales ante la comunidad universitaria que se dio cita en el encuentro. El uso de herramientas tecnológicas para la gestión de los trabajos de investigación como la plataforma Open Conference Systems y la web de presentación del Congreso http://citis.blog.ups.edu.ec/, hicieron de CITIS 2017 un verdadero referente entre los congresos que se desarrollaron en el país. La preocupación de nuestra Universidad, de presentar espacios que ayuden a generar nuevos y mejores cambios en la dimensión humana y social de nuestro entorno, hace que se persiga en cada edición del evento la presentación de trabajos con calidad creciente en cuanto a su producción científica. Quienes estuvimos al frente de la organización, dejamos plasmado en estas memorias académicas el intenso y prolífico trabajo de los días de realización del Congreso Internacional de Ciencia, Tecnología e Innovación para la Sociedad al alcance de todos y todas

La renovación de la palabra en el bicentenario de la Argentina : los colores de la mirada lingüística

El libro reúne trabajos en los que se exponen resultados de investigaciones presentadas por investigadores de Argentina, Chile, Brasil, España, Italia y Alemania en el XII Congreso de la Sociedad Argentina de Lingüística (SAL), Bicentenario: la renovación de la palabra, realizado en Mendoza, Argentina, entre el 6 y el 9 de abril de 2010. Las temáticas abordadas en los 167 capítulos muestran las grandes líneas de investigación que se desarrollan fundamentalmente en nuestro país, pero también en los otros países mencionados arriba, y señalan además las áreas que recién se inician, con poca tradición en nuestro país y que deberían fomentarse. Los trabajos aquí publicados se enmarcan dentro de las siguientes disciplinas y/o campos de investigación: Fonología, Sintaxis, Semántica y Pragmática, Lingüística Cognitiva, Análisis del Discurso, Psicolingüística, Adquisición de la Lengua, Sociolingüística y Dialectología, Didáctica de la lengua, Lingüística Aplicada, Lingüística Computacional, Historia de la Lengua y la Lingüística, Lenguas Aborígenes, Filosofía del Lenguaje, Lexicología y Terminología

Sedimentology and stratigraphy of the Puesto El Moro Formation, Patagonia, Argentina: Implications for upper cretaceous paleogeographic reconstruction and compartmentalization of the Austral-Magallanes Basin

During the Late Cretaceous, the Austral-Magallanes Basin (AMB) records the change from a thermal subsidence post-rift stage to a retroarc foreland basin scenario. The lower-Upper Cretaceous Puesto El Moro Formation (PMF) was deposited during the configuration of the foreland AMB. The aims of this contribution are: (i) to define the sedimentary paleoenvironments that are recorded by the PMF deposits and their spatio-temporal distribution, and (ii) to reconstruct the paleogeographic configuration and distributions of the sedimentary environments in the AMB during the early-Late Cretaceous onset of the foreland system. Based on detailed sedimentological observations and analysis of architectural elements, we divide the PMF into three informal sections. The lower section of the PMF represents a shallowing-upward estuary bay succession. The middle section of the PMF is characterized by braided and high-sinuosity meandering fluvial systems, flowing toward the southwest. Finally, the upper section of the PMF corresponds to a distributive fluvial system flowing toward the southwest. The PMF accumulated synchronously with the estuarine-fluvial Mata Amarilla Formation (MAF) located to the east of the study area. The results obtained in this contribution suggest that the type and vertical stacking of sedimentary paleoenvironments of the PMF could be correlated with the contemporary MAF. A subsurface dataset supported by the oil industry indicates the occurrence of the SE-trending Piedra Clavada High inside the northern AMB. We interpret that this topographic high controlled, during the Late Cretaceous, the types and distribution of sedimentary paleoenvironments of the AMB, indicating that an important compartmentalization of the basin occurred during the beginning of the foreland stage. The northern part of the AMB is divided into the Cardiel-Tres Lagos sub-basin and the Foredeep main depocentre.Fil: Varela, Augusto Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; ArgentinaFil: Richiano, Sebastián Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Geología y Paleontología; ArgentinaFil: D´Elia, Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; ArgentinaFil: Moyano Paz, Damián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; ArgentinaFil: Tettamanti, Camila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; ArgentinaFil: Poire, Daniel Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Geológicas. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Centro de Investigaciones Geológicas; Argentin

Mechanisms involved in memory processes: Alterations induced by psychostimulants - Targeting the central AT1 receptors

Learned experiences are indispensable for adaptation and survival ofeveryliving organism. The generation of a memory trace is an activephysiological process which implies association and organization of thenew impressions with already stored ones. Therefore, memory is explainedas activity-dependent synaptic plasticity, involving electrophysiological,biochemical and morphological changes in functional synapse.Throughout the different stages of information processing, emotionand memories interact to shape data encoding and retrieval. Dopamineplays a key role in the control of mood, fear and anxiety, and modulatesthe biochemical processes of memory. Hence, more plastic and appropriateresponses can be achieved to variable external demands.Among drugs of abuse worldwide consumed, psychostimulants areknown for their stimulant properties within the central nervous system.Monoaminergic neurotransmission elicited by amphetamine alters neuronalconnectivity in several brain areas; thus, its pharmacological actionscan be extended to learning and memory processes. Evidence indicates acomplex scenario after psychostimulant administration where long-termmemory can be either impaired or enhanced, according to the experimentalconditions.Fil: Marchese, Natalia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Basmadjian, Osvaldo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Occhieppo, Victoria Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; ArgentinaFil: Baiardi, Gustavo Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Bregonzio Diaz, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Farmacología Experimental de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Farmacología Experimental de Córdoba; Argentin

Cell wall phenylpropanoid-related gene expression in early maize recombinant inbred lines differing in parental alleles at a major lignin QTL position

Fifteen quantitative trait loci (QTL) for cell wall digestibility and lignin content were shown in the recombinant inbred line (RIL) progeny descended from the cross between F288 and F271, two early dent lines of contrasted cell wall digestibility. Among these QTL, those located in bin 6.06, respectively explained 20 and 40% of the phenotypic variation for lignin content and cell wall digestibility. Expression of genes related to cell wall and lignin biosynthesis was investigated with the ‘‘MaizeWall’’ macro-array in two RIL having favorable alleles for low lignin content and high cell wall digestibility, except in bin 6.06 where RIL39 and RIL99 had unfavorable and favorable alleles, respectively. In the lignin pathway, three PAL, 4CL1, ZmCCR1, COMT, and ZmCAD2 genes were under-expressed in RIL99 in comparison to RIL39. In addition, two cytochrome P450, ZmCHS, and ZmCHI1 genes were simultaneously under-expressed while F5H2 and two OMT ZRP4-like genes were over-expressed. However, none of these genes were mapped in bin 6.06. Based on maize–rice synteny and on Maize Genome Sequencing Project data, several putative candidate genes related to lignin content and lignified tissue patterning were found in the support interval of bin 6.06 QTL. These genes included one C30H which is likely the missing constitutive gene of the maize lignin pathway. Three ZRP4-like OMT were also shown in the support interval of the QTL. However, their involvement in the lignin pathway has not yet been firmly established. Several regulation or transcription factors were also shown in the QTL support interval. Among them, MYB, zinc finger, bZIP, and COV1 genes belong to families with members involved in lignification regulation or in lignified tissue patterning. In addition, auxin response factors have been shown to be indirectly involved in plant lignification. Moreover, several genes encoding proteins of unknown function and genes annotated ‘‘retrotransposon-like’’ were also located in the QTL support interval. Current results are not conclusive on the candidate gene discovery, but strengthen the hypothesis that regulation genes are better candidates than genes involved in the monolignol pathway. Fine mapping, association genetics, and/or functional validation have to be considered for more definite conclusions