84 research outputs found
B cell heterogeneity. I. A study of b cell subpopulations involved in the reconstitution of an x-linked immune defect of b cell differentiaiton.
Monoclonal antibody directed to a B-cell antigen present in rats, mice, and humans.
Spleen cells from a LEW.AVN rat immunized with cells from an MNR rat were fused with mouse myeloma cells to produce hybrid cell lines. One of these hybridomas produced a monoclonal antibody that was cytotoxic for bone marrow-derived (B) but not thymus-derived (T) cells. The antigen defined by this antibody is determined by a gene linked to the major histocompatibility complex (MHC). The antigen is also present on B cells of most mouse strains and is determined by an MHC-linked gene in this species as well. In both rats and mice, the gene determining the antigen maps within the immune response region of the MHC. All human B-cell lines, but not T-cell lines, and B but not T cells of all human donors tested so far are also positive for this antigen. Among human-mouse somatic cell lines that have lost various human chromosomes, this B-cell antigen is present on all lines that are positive for HLA antigen but is absent from all lines that have lost HLA
Monoclonal rat anti-major histocompatibility complex antibodies display specificity for rat, mouse, and human target cells.
Specific Systemic Graft-Versus-Host Resistance: Failure to Induce in Adult F1 Rats Tolerized at Birth to Anti-MHC Receptors on Parental T Cells
Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population.
Site-specific covalent modification of monoclonal antibodies: in vitro and in vivo evaluations.
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