Twenty Years of Timing SS433

We present observations of the optical ``moving lines'' in spectra of the Galactic relativistic jet source SS433 spread over a twenty year baseline from 1979 to 1999. The red/blue-shifts of the lines reveal the apparent precession of the jet axis in SS433, and we present a new determination of the precession parameters based on these data. We investigate the amplitude and nature of time- and phase-dependent deviations from the kinematic model for the jet precession, including an upper limit on any precessional period derivative of $\dot P < 5 \times 10^{-5}$. We also dicuss the implications of these results for the origins of the relativistic jets in SS433.Comment: 21 pages, including 9 figures. To appear in the Astrophysical Journa

Solitons supported by localized nonlinearities in periodic media

Nonlinear periodic systems, such as photonic crystals and Bose-Einstein condensates (BECs) loaded into optical lattices, are often described by the nonlinear Schr\"odinger/Gross-Pitaevskii equation with a sinusoidal potential. Here, we consider a model based on such a periodic potential, with the nonlinearity (attractive or repulsive) concentrated either at a single point or at a symmetric set of two points, which are represented, respectively, by a single {\delta}-function or a combination of two {\delta}-functions. This model gives rise to ordinary solitons or gap solitons (GSs), which reside, respectively, in the semi-infinite or finite gaps of the system's linear spectrum, being pinned to the {\delta}-functions. Physical realizations of these systems are possible in optics and BEC, using diverse variants of the nonlinearity management. First, we demonstrate that the single {\delta}-function multiplying the nonlinear term supports families of stable regular solitons in the self-attractive case, while a family of solitons supported by the attractive {\delta}-function in the absence of the periodic potential is completely unstable. We also show that the {\delta}-function can support stable GSs in the first finite gap in both the self-attractive and repulsive models. The stability analysis for the GSs in the second finite gap is reported too, for both signs of the nonlinearity. Alongside the numerical analysis, analytical approximations are developed for the solitons in the semi-infinite and first two finite gaps, with the single {\delta}-function positioned at a minimum or maximum of the periodic potential. In the model with the symmetric set of two {\delta}-functions, we study the effect of the spontaneous symmetry breaking of the pinned solitons. Two configurations are considered, with the {\delta}-functions set symmetrically with respect to the minimum or maximum of the potential

NASSAM: a server to search for and annotate tertiary interactions and motifs in three-dimensional structures of complex RNA molecules

Similarities in the 3D patterns of RNA base interactions or arrangements can provide insights into their functions and roles in stabilization of the RNA 3D structure. Nucleic Acids Search for Substructures and Motifs (NASSAM) is a graph theoretical program that can search for 3D patterns of base arrangements by representing the bases as pseudo-atoms. The geometric relationship of the pseudo-atoms to each other as a pattern can be represented as a labeled graph where the pseudo-atoms are the graph's nodes while the edges are the inter-pseudo-atomic distances. The input files for NASSAM are PDB formatted 3D coordinates. This web server can be used to identify matches of base arrangement patterns in a query structure to annotated patterns that have been reported in the literature or that have possible functional and structural stabilization implications. The NASSAM program is freely accessible without any login requirement at http://mfrlab.org/grafss/nassam/

Structural and Functional Analysis of a β2-Adrenergic Receptor Complex with GRK5.

The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling. While a structural understanding of GPCR/G-protein and GPCR/arrestin complexes has emerged in recent years, the molecular architecture of a GPCR/GRK complex remains poorly defined. We used a comprehensive integrated approach of cross-linking, hydrogen-deuterium exchange mass spectrometry (MS), electron microscopy, mutagenesis, molecular dynamics simulations, and computational docking to analyze GRK5 interaction with the β2-adrenergic receptor (β2AR). These studies revealed a dynamic mechanism of complex formation that involves large conformational changes in the GRK5 RH/catalytic domain interface upon receptor binding. These changes facilitate contacts between intracellular loops 2 and 3 and the C terminus of the β2AR with the GRK5 RH bundle subdomain, membrane-binding surface, and kinase catalytic cleft, respectively. These studies significantly contribute to our understanding of the mechanism by which GRKs regulate the function of activated GPCRs. PAPERCLIP

From the Chern-Simons theory for the fractional quantum Hall effect to the Luttinger model of its edges

The chiral Luttinger model for the edges of the fractional quantum Hall effect is obtained as the low energy limit of the Chern-Simons theory for the two dimensional system. In particular we recover the Kac-Moody algebra for the creation and annihilation operators of the edge density waves and the bosonization formula for the electronic operator at the edge.Comment: 4 pages, LaTeX, 1 Postscript figure include

Coulomb Drag of Edge Excitations in the Chern-Simons Theory of the Fractional Quantum Hall Effect

Long range Coulomb interaction between the edges of a Hall bar changes the nature of the gapless edge excitations. Instead of independent modes propagating in opposite directions on each edge as expected for a short range interaction one finds elementary excitations living simultaneously on both edges, i.e. composed of correlated density waves propagating in the same direction on opposite edges. We discuss the microscopic features of this Coulomb drag of excitations in the fractional quantum Hall regime within the framework of the bosonic Chern-Simons Landau-Ginzburg theory. The dispersion law of these novel excitations is non linear and depends on the distance between the edges as well as on the current that flows through the sample. The latter dependence indicates a possibility of parametric excitation of these modes. The bulk distributions of the density and currents of the edge excitations differ significantly for short and long range interactions.Comment: 11 pages, REVTEX, 2 uuencoded postscript figure

Implementing a participatory model of micro health insurance among rural poor with evidence from Nepal

This paper reports on two voluntary, contributory, contextualised, community-based health insurance (CBHI) schemes, launched in Dhading and Banke (Nepal) in 2011. The implementation followed a four-stage process: initiating (baseline survey), involving (awareness generation and engaging community in benefit-package-design), launch (enrolment and training of selected community members) and post-launch (viable claims ratio, settled within satisfactory time, sustainable affiliation). Both schemes were successful on four key parameters: effective planning; affiliation (grew from 0 to ∼10,000) and renewals (>65 per cent); claims ratio (∼50 per cent); and promptness of claim settlement (∼23 days). This model succeeded in implementing CBHI with zero premium subsidies or subsidised health-care costs. The successful operation relied in large part on the fact that members trust that they can enforce this contract. Considerable insurance education and capacity development is necessary before the launch of the CBHI, and for sustainable operations as well as for scaling

What factors affect voluntary uptake of community-based health insurance schemes in low- and middle-income countries? A systematic review and meta-analysis

Introduction: This research article reports on factors influencing initial voluntary uptake of community-based health insurance (CBHI) schemes in low- and middle-income countries (LMIC), and renewal decisions. Methods: Following PRISMA protocol, we conducted a comprehensive search of academic and gray literature, including academic databases in social science, economics and medical sciences (e.g., Econlit, Global health, Medline, Proquest) and other electronic resources (e.g., Eldis and Google scholar). Search strategies were developed using the thesaurus or index terms (e.g., MeSH) specific to the databases, combined with free text terms related to CBHI or health insurance. Searches were conducted from May 2013 to November 2013 in English, French, German, and Spanish. From the initial search yield of 15,770 hits, 54 relevant studies were retained for analysis of factors influencing enrolment and renewal decisions. The quantitative synthesis (informed by meta-analysis) and the qualitative analysis (informed by thematic synthesis) were compared to gain insight for an overall synthesis of findings/statements. Results: Meta-analysis suggests that enrolments in CBHI were positively associated with household income, education and age of the household head (HHH), household size, female-headed household, married HHH and chronic illness episodes in the household. The thematic synthesis suggests the following factors as enablers for enrolment: (a) knowledge and understanding of insurance and CBHI, (b) quality of healthcare, (c) trust in scheme management. Factors found to be barriers to enrolment include: (a) inappropriate benefits package, (b) cultural beliefs, (c) affordability, (d) distance to healthcare facility, (e) lack of adequate legal and policy frameworks to support CBHI, and (f) stringent rules of some CBHI schemes. HHH education, household size and trust in the scheme management were positively associated with member renewal decisions. Other motivators were: (a) knowledge and understanding of insurance and CBHI, (b) healthcare quality, (c) trust in scheme management, and (d) receipt of an insurance payout the previous year. The barriers to renewal decisions were: (a) stringent rules of some CBHI schemes, (b) inadequate legal and policy frameworks to support CBHI and (c) inappropriate benefits package. Conclusion and Policy Implications: The demand-side factors positively affecting enrolment in CBHI include education, age, female household heads, and the socioeconomic status of households. Moreover, when individuals understand how their CBHI functions they are more likely to enroll and when people have a positive claims experience, they are more likely to renew. A higher prevalence of chronic conditions or the perception that healthcare is of good quality and nearby act as factors enhancing enrolment. The perception that services are distant or deficient leads to lower enrolments. The second insight is that trust in the scheme enables enrolment. Thirdly, clarity about the legal or policy framework acts as a factor influencing enrolments. This is significant, as it points to hitherto unpublished evidence that governments can effectively broaden their outreach to grassroots groups that are excluded from social protection by formulating supportive regulatory and policy provisions even if they cannot fund such schemes in full, by leveraging people's willingness to exercise voluntary and contributory enrolment in a community-based health insurance

Ergodic properties of quasi-Markovian generalized Langevin equations with configuration dependent noise and non-conservative force

We discuss the ergodic properties of quasi-Markovian stochastic differential equations, providing general conditions that ensure existence and uniqueness of a smooth invariant distribution and exponential convergence of the evolution operator in suitably weighted $L^{\infty}$ spaces, which implies the validity of central limit theorem for the respective solution processes. The main new result is an ergodicity condition for the generalized Langevin equation with configuration-dependent noise and (non-)conservative force

Bosonization for Wigner-Jordan-like Transformation : Backscattering and Umklapp-processes on Fictitious Lattice

We analyze the asymptotic behavior of the exponential form in the fermionic density operators as the function of ruling parameter Q. In the particular case Q=\pi this exponential associates with the Wigner-Jordan transformation for XY spin chain model. We compare the bosonization approach and the evaluation via the Toeplitz determinant. The use of Szego-Kac theorem suggests that at Q>\pi/3 the divergent series for intrinsic logarithm provides a bosonized solution and faster decaying one, found as the logarithm's value on another sheet of the complex plane. The second solution is revealed as umklapp-process on the fictitious lattice while originates from backscattering terms in bosonized density. Our finding preserves in a wide range of fermion filling ratios.Comment: 8 pages, REVTEX, 3 eps figures, accepted to Phys.Rev.