West-Central Asia: a comparative analysis of students’ trajectories in Russia (Moscow) from the 1980s and China (Yiwu) from the 2000s

Through an exploration of oral history and ethnographic material, this article makes a comparative examination of the life-trajectories of students from Yemen, Iraq, and Afghanistan who studied in Russia (Moscow) during the late 1980s, and from Tajikistan, Iran, Azerbaijan and Saudi Arabia who studied in China in the 2000s. In contrast to the cohort of students in Moscow who were mainly men from places with relatively amicable relations with the USSR, the female students of Muslim background from West and Central Asia regarded China as a place where they could pursue fulfilling forms of economic and personal autonomy. By comparing these two groups of international students, this article sheds light into the nature of historical, geographical and geopolitical connections and disconnections between West-Central Asia, Eurasia (especially Russia) and East Asia (especially China). By centring its attention to the demise of Soviet/Russian education and the emergence of China as a figure of economic prosperity, the article theorises West-Central Asia as a particular arena of interaction suitable to comprehend the networks, ‘third spaces’ or zones of interaction (e.g. Moscow and Yiwu), and forms of connection fostered by these students’ trajectories

Emerging pharmacotherapy of tinnitus

Tinnitus, the perception of sound in the absence of an auditory stimulus, is perceived by about 1 in 10 adults, and for at least 1 in 100, tinnitus severely affects their quality of life. Because tinnitus is frequently associated with irritability, agitation, stress, insomnia, anxiety and depression, the social and economic burdens of tinnitus can be enormous. No curative treatments are available. However, tinnitus symptoms can be alleviated to some extent. The most widespread management therapies consist of auditory stimulation and cognitive behavioral treatment, aiming at improving habituation and coping strategies. Available clinical trials vary in methodological rigor and have been performed for a considerable number of different drugs. None of the investigated drugs have demonstrated providing replicable long-term reduction of tinnitus impact in the majority of patients in excess of placebo effects. Accordingly, there are no FDA or European Medicines Agency approved drugs for the treatment of tinnitus. However, in spite of the lack of evidence, a large variety of different compounds are prescribed off-label. Therefore, more effective pharmacotherapies for this huge and still growing market are desperately needed and even a drug that produces only a small but significant effect would have an enormous therapeutic impact. This review describes current and emerging pharmacotherapies with current difficulties and limitations. In addition, it provides an estimate of the tinnitus market. Finally, it describes recent advances in the tinnitus field which may help overcome obstacles faced in the pharmacological treatment of tinnitus. These include incomplete knowledge of tinnitus pathophysiology, lack of well-established animal models, heterogeneity of different forms of tinnitus, difficulties in tinnitus assessment and outcome measurement and variability in clinical trial methodology. © 2009 Informa UK Ltd.Fil: Langguth, Berthold. Universitat Regensburg; AlemaniaFil: Salvi, Richard. State University of New York; Estados UnidosFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentin

TRH: Pathophysiologic and clinical implications

Thyrotropin releasing hormone is thought to be a tonic stimulator of the pituitary TSH secretion regulating the setpoint of the thyrotrophs to the suppressive effect of thyroid hormones. The peptide stimulates the release of normal and elevated prolactin. ACTH and GH may increase in response to exogenous TRH in pituitary ACTH and GH hypersecretion syndromes and in some extrapituitary diseases. The pathophysiological implications of extrahypothalamic TRH in humans are essentially unknown. The TSH response to TRH is nowadays widely used as a diganostic amplifier in thyroid diseases being suppressed in borderline and overt hyperthyroid states and increased in primary thyroid failure. In hypothyroid states of hypothalamic origin, TSH increases in response to exogenous TRH often with a delayed and/or exaggerated time course. But in patients with pituitary tumors and suprasellar extension TSH may also respond to TRH despite secondary hypothyroidism. This TSH increase may indicate a suprasellar cause for the secondary hypothyroidism, probably due to portal vessel occlusion. The TSH released in these cases is shown to be biologically inactive

China\u27s hegemonic intentions and trajectory: Will it opt for benevolent, coercive, or Dutch‐style hegemony?

China\u27s unprecedented economic growth led some scholars to conclude that it will replace the United States as the future global hegemon. However, China\u27s intentions in exercising future global leadership are yet unknown and difficult to extrapolate from its often contradictory behaviour. A preliminary overview of China\u27s island building in the South China Sea reveals its potentially coercive intentions. This inference is consistent with the analysis of those who prognosticate China\u27s violent rise. Conversely and simultaneously, China\u27s participation in peacekeeping operations and its global investments evince its benevolent hegemonic intentions, which are congruent with the argument of those who predict China\u27s peaceful hegemonic ascent. Confronted with these divergent tendencies in China\u27s recent international relations, and assuming its continued rise, it is, thus, essential to examine China\u27s strategic intentions and how these may ultimately project its violent or peaceful hegemonic rise. This article argues that the “Third Way” or “Dutch‐style” hegemony is highly instructive in this context and, thus, should be examined and added to the existing debate on China\u27s rise as either a benevolent or coercive hegemon. We argue that Dutch‐style hegemony may be the most viable way for China to proceed in its global hegemonic ascendancy

Going global or going nowhere? Chinese media in a time of flux

This article focuses on how Chinese media industries have sought to expand into new territories, identifying several mechanisms by which Chinese cultural and media products are traded and consumed: namely finished content, co-productions, formats and online platforms. The article also considers the value of overseas location shooting for domestic programmes and acquisition of international media assets. The key idea that is discussed in regards to China's outward-bound trade mission is know-how. In respect to media production, producers tend to opt for risk avoidance rather than creative exploration. Consequently, Chinese producers, investors and practitioners are deficient in knowledge of international markets and audience perceptions because the government has chosen to intervene, select and guide Chinese products. The article suggests this is gradually changing

New Measures of the Trilemma Hypothesis: Implications for Asia

We develop a new set of indexes of exchange rate stability, monetary policy independence, and financial market openness as the metrics for the trilemma hypothesis. In our exploration, we take a different and more nuanced approach than the previous indexes developed by Aizenman, Chinn, and Ito (2008). We show that the new indexes add up to the value two, supporting the trilemma hypothesis. We locate our sample economies' policy mixes in the famous trilemma triangle - a useful and intuitive way to illustrate the state and evolution of policy mixes. We also examine if the persistent deviation of the sum of the three indexes from the value two indicates an unsustainable policy mix and therefore needs to be corrected by economic disruptions such as economic and financial crises. We obtain several findings. First, such a persistent deviation can occur particularly in emerging economies that later experience an inflation (or potentially a general or a currency) crisis, and dissipates in the postcrisis period. Second, there is no evidence for this type of association between deviations from the trilemma constraint and general, banking, or debt crises. Third, Thailand experienced such a deviation from the trilemma constraint in the period leading to the baht crisis of 1997, but not other East and Southeast Asian economies. This last result suggests that the main cause for the Thai baht crisis was an unsustainable policy mix in the precrisis period, while other affected economies experienced crises mainly due to contagion from Thailand

Do leaders matter? : Chinese politics, leadership transition and the 17th Party Congress

The opaque nature of decision making in China has generated considerable interest in the internecine machinations of elite politics. Particularly, but not only, when it comes to issues of leadership transition, considerations of factional formation and conflict come to the fore. This is partly to explain the transition process itself, but also out of concern for how new leaders might change the direction of Chinese policy. This paper suggests that whilst leaders and leadership changes do matter, they matter less than they once did. This is partly a result of the de-ideologicization and increasing diverse nature of elite interests and group formation. But it is also partly a result of the changed nature of China’s political economy; in short, there is less desire and less ability for new leaders to impose a clear paradigm shift

The State Dependent Impact of Bank Exposure on Sovereign Risk

The theoretical literature remains inconclusive on whether changes in bank exposure towards the domestic sovereign have an adverse effect on the sovereign risk position via a diabolic loop in the sovereign-bank nexus or reduce perceived default risk by acting as a disciplinary device for the sovereign. In this paper we empirically analyze the impact of exogenous changes in bank exposure on the risk position of the sovereign within a Markov switching structural vector autoregressive in heteroscedasticity (MSH-SVAR) framework for a set of EMU countries. We add to the methodological literature by allowing for regime dependent shock transmissions according to the volatility state of the financial system. Finding support for both, a stabilizing and a destabilizing effect, we document a clear clustering among the country sample: Rising bank exposure increased default risk for the EMU periphery, but decreased credit risk for the core EMU countries during times of financial stress

The cultural power metric: Toward a reputational analysis of China’s soft power in the Asia-Pacific

The advent of new media technologies has changed how people watch, engage with, and share digital media. Conventionally, audiences were surveyed selectively, and the results were collated by professional agencies and often kept confidential. However, the conspicuous ratings given to media and cultural products outside their country of origin and their very public success and failure raises questions about the validity of such methods, particularly at a time when media and cultural products are used as proxies for cultural “soft power.” This term, first used by Joseph Nye in a political context, evokes reputational impact: a particular nation’s cultural and media products can “go global” if they prove sufficiently popular, reflecting positively on the originating nation. This article examines the various methods used to evaluate China’s “cultural power.” It notes the current weighting given to the humanities and social sciences. By applying some basic big data analysis and machine-learning techniques, the authors build on previous studies by offering new insights into the rise of “Digital China” and China’s digital and Internet trailblazers. The authors consider two major international metrics, as well as China’s early experimental attempts at devising its own standard, before introducing an alternative model, the cultural power metric