A germline TaqI restriction fragment length polymorphism in the progesterone receptor gene in ovarian carcinoma.

Clinical outcome in ovarian carcinoma is predicted by progesterone receptor status, indicating an endocrine aspect to this disease. Peripheral leucocyte genomic DNAs were obtained from 41 patients with primary ovarian carcinoma and 83 controls from Ireland, as well as from 26 primary ovarian carcinoma patients and 101 controls in Germany. Southern analysis using a human progesterone receptor (hPR) cDNA probe identified a germline TaqI restriction fragment length polymorphism (RFLP) defined by two alleles: T1, represented by a 2.7 kb fragment; and T2, represented by a 1.9 kb fragment and characterised by an additional TaqI restriction site with respect to T1. An over-representation of T2 in ovarian cancer patients compared with controls in the pooled Irish/German population (P < 0.025) was observed. A difference (P < 0.02) in the distribution of the RFLP genotypes between Irish and German control populations was also observed. The allele distributions could not be shown to differ significantly from Hardy-Weinberg distribution in any subgroup. Using hPR cDNA region-specific probes, the extra TaqI restriction site was mapped to intron G of the hPR gene

Intron variants of the p53 gene are associated with increased risk for ovarian cancer but not in carriers of BRCA1 or BRCA2 germline mutations

Two biallelic polymorphisms in introns 3 and 6 of the p53 gene were analysed for a possible risk-modifying effect for ovarian cancer. Germline DNA was genotyped from 310 German Caucasian ovarian cancer patients and 364 healthy controls. We also typed 124 affected and 276 unaffected female carriers with known deleterious BRCA1 or BRCA2 germline mutation from high-risk breast-ovarian cancer families. Genotyping was based on PCR and high-resolution gel electrophoresis. German ovarian cancer patients who carried the rare allele of the MspI restriction fragment length polymorphism (RELP) in intron 6 were found to have an overall 1.93-fold increased risk (95% confidence internal (CI) 1.27–2.91) which further increased with the age at diagnosis of 41–60 years (odds ratio (OR) 2.71, 95% CI 1.10–6.71 for 41–50 and OR 2.44, 95% CI 1.12–5.28 for 51–60). The 16 bp duplication polymorphism in intron 3 was in a strong linkage to the MspI RFLP. In BRCA1 or BRCA2 mutation carriers, no difference in allele frequency was observed for carriers affected or unaffected with ovarian cancer. Our data suggest that intronic polymorphisms of the p53 gene modify the risk for ovarian cancer patients but not in carriers with BRCA1 or BRCA2 mutations. © 1999 Cancer Research Campaig

Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies

Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts

Preface for the special section of the JACerS on sintering. Editorial

This special section of the Journal of the American Ceramic Society includes a number of papers presented at the International Conference on Sintering 2017, which was held in San Diego, USA, on November 12‐16, 2017. The meeting was chaired by Professors Rajendra K. Bordia, Eugene A. Olevsky, Didier Bouvard, Suk‐Joong L. Kang, and Bernd Kieback. This was the eighth meeting in a series that started in 1995 as a continuation of the well‐known cycle of conferences on sintering and related phenomena organized by G. Kuczynski which ran from 1967 to 1983. The first seven meetings in this re‐established series of conferences were held at Pennsylvania State University, USA in 1995, 1999 and 2003; in Grenoble, France in 2005; in San Diego, USA in 2008; in Jeju Island, South Korea in 2011, and in Dresden, Germany in 2014. Sintering 2017 brought together more than 240 participants from 29 countries, fostering a high level of scientific interaction and creating an atmosphere of broad international collaboration. The meeting included participants from North and Central America, Europe (both Eastern and Western), Asia, Australia, and Africa. The conference demonstrated the advances that have been made in the areas of the modeling of sintering phenomena at multiple scale levels, including the fundamentals of microstructure development, and promoted a better understanding of the processing of complex systems (nanostructured, multi‐layered, composite, and reactive systems). Concerning sintering technology, innovative approaches such as field‐assisted sintering and application of sintering in additive manufacturing attracted the attention of the materials processing community. This collection of papers published in the special section of the Journal of the American Ceramic Society cover the rich diversity of the sintering science and technology topics presented at the conference. They focus on leading developments in sintering science and technology in both powder metallurgy and ceramic processing. In addition to selected papers presented at the Sintering 2017, this issue contains other papers on sintering since it is such an important topic in ceramic science and the technology of processing ceramics. We are thankful to the authors and reviewers of these papers who had to meet strict deadlines to enable the timely publication of this special issue of the Journal of the American Ceramic Society. We also thank William Fahrenholtz, Editor‐in‐Chief of the Journal of the American Ceramic Society; Jonathon Foreman, Managing Editor; Michelle Martin, Publication Services Specialist; and Greg Geiger, Technical Content Manager from the Technical Publications Office of the American Ceramic Society for working with us in development and production of this special issue. We hope the articles in this special section will be a significant addition to the scientific and technical literature on sintering and microstructure development, and we are looking forward to seeing you at future Sintering conferences

Stoerbeeinflussung von Herzschrittmachern

Special print from: Informationen fuer den Betriebsarzt no. 2/86SIGLECopy held by FIZ Karlsruhe; available from UB/TIB Hannover / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

Machinable porous gold structures for decorative applications made via supersolidus liquid phase sintering

Typical 18 ct. gold alloys like white, yellow, and red gold lend themselves for supersolidus liquid phase sintering due to a sufficient difference between solidus and liquidus temperature. In search of non-conventional design opportunities for decorative applications, this fact has been successfully exploited in this feasibility study for the manufacturing of sintered 18 ct. gold fiber structures from all three gold varieties as well as a foam-type material from yellow gold. Obtained porosities ranged from approximately 50 to 70 % for the fiber structures and reached up to 94.5 % for the foams. In order to make precisely shaped parts from these porous gold materials, a high-speed milling route was developed. Determination of favourable sintering conditions A literature survey on sintering of gold alloys was conducted, the most relevant findings of which are discussed below. [1] reports on the powder metallurgical production of wedding rings made from 9 ct. gold alloy (37.5 wt% Au, rest Ag, Cu, Zn and others). In order to prevent Cu and Zn from oxidising, a controlled oxygen-free atmosphere is recommended. Sintering was carried out 20 degrees below the solidus temperature at 780 °C for 24 hours in an atmosphere comprised of 95 % N 2 and 5 % H 2 with good results. The production of metal injection moulded parts from 18 ct. gold alloys is reported in [2]. In comparison with precision-cast parts, the obtained microstructure is much finer and thus provides better properties. Debindering and sintering takes about 65 hours. From the diagrams provided in the paper, it can be deduced that the sintering time amounts to roughly 24 hours. According to the authors, sintering was carried out at a temperature of 80 to 90 % of the melting temperature. The quasi-binary phase diagram (Fig. 1) reproduced from [3] indicates that such a sintering temperature would clearly correspond to solid state sintering conditions. The applied sintering atmosphere was 80 % Ar and 20 % H 2. Like other authors, [2] acknowledges the role of the gas flow and recommends low mass flows in order to warrant equal temperature conditions throughout the samples. Problems with remaining porosity are explained in terms of inhomogeneous packing of the powder particles