Crowd Search: Generic Crowd Sourcing Systems Using Query Optimization

We think about the query optimization issue in Generic crowdsourcing system. Generic crowdsourcing is intended to conceal the complexities and calm the client the weight of managing the group. The client is just needed to present a SQL-like question and the framework assumes the liability of arranging the inquiry, creating the execution plan and assessing in the crowdsourcing commercial center. A given query can have numerous options execution arranges and the distinction in crowdsourcing expense between the best and the most exceedingly worst arranges may be a few requests of extent. In this manner, as in social database frameworks, query optimization is imperative to crowdsourcing frameworks that give revelatory question interfaces. In this paper, we propose CROWDOP, an expense based query advancement approach for explanatory crowdsourcing frameworks. CROWDOP considers both cost and latency in query advancement destinations and produces question arranges that give a decent harmony between the cost and latency. We create proficient calculations in the CROWDOP for upgrading three sorts of inquiries: selection queries join queries, and complex selection-join queries. Deco is a far reaching framework for noting decisive questions postured over put away social information together with information got on demand from the group. In this paper we assume Deco's cost based query streamlining agent, expanding on Deco's information model, query dialect, and query execution motor exhibited befor

Power-efficient adaptive behavior through a shape-changing elastic robot

The adaptive morphology of a robot, such as shape adaptation, plays a significant role in adapting its behaviors. Shape adaptation should ideally be achieved without considerable cost, like the power required to deform the robot’s body, and therefore, it is reasonably considered as the last resort in classical rigid robots. However, the last decade has seen an increasing interest in soft robots: robots that can achieve deformability through their inherent material properties or structural compliance. Nevertheless, the dynamics of these types of robots is often complex and therefore it is difficult to substantiate whether the cost like the required power for changing its shape will be worthwhile to achieve the desired behavior. This article presents an approach in the development and analysis of a shape-changing locomoting robot, which relies on the ability of elastic beams to deform and vibrate. Through a proper use of elastic materials and the robot’s vibration-based dynamics, it will be shown both analytically and experimentally how shape adaptation can be designed such that it leads to desirable behaviors, with better power efficiency compared to when the robot solely relies on changing its control input. The results encourage emerging direction in robotics that investigates approaches to change robots’ behaviors through their adaptive morphology. </jats:p

Site-directed mutagenesis of Saccharomyces cerevisiae β-tubulin: interaction between residue 167 and benzimidazole compounds

AbstractBenzimidazoles are widely used as anthelmintic agents and systemic fungicides. In susceptible organisms, benzimidazoles bind to β-tubulin and block microtubule polymerization. To further characterize this interaction, site-directed mutagenesis followed by gene replacement was used to change Saccharomyces cerevisiae β-tubulin residue Phe-167 to Tyr. Consistent with previous studies, this mutation resulted in at least 3–4-fold decreased sensitivity to the benzimidazole derivatives carbendazim and nocodazole. The Tyr-167 mutant was cold sensitive, implying a direct effect on benzimidazole binding rather than a nonspecific increase in microtubule stability. Surprisingly, the mutant had 8-fold increased sensitivity to the derivative benomyl, which is structurally identical to carbendazim except at position 1. This suggests that residue 167 interacts with benzimidazoles in the vicinity of the 1-position

Observational study of tympanic membrane changes in allergic rhinitis

Background: Allergic rhinitis (AR) is a common condition affecting 20-30% of the population. This condition affects not only the nose but also the sinuses and ears in many ways. Many studies are there worldwide implicating AR as a cause of serous otitis media. But only few studies have actually studied the tympanic membrane (TM) changes observed in patients with allergic rhinitis. The aim of this study is to document the TM changes observed in patients with AR and to correlate them with the duration of symptoms and also influence of prior treatment of AR on the TM changes observed.Methods: A total of 111 patients and so 222 ears were studied. A detailed history of the duration of symptoms and any prior treatment for AR was recorded. The TM changes seen were classified and recorded. The duration of disease and treatment were taken as grouping variables and the tympanic membrane changes were ranked and used as testing variable. The results were statistically analyzed using non- parametric test, Kruskal – Wallis test.Results: There was no statistically significant correlation between duration of AR and the TM changes observed. However there was a significantly less number of patients with TM retraction observed in the patients who had taken prior treatment compared to those patients who had taken no prior treatment.Conclusions: It is concluded that institution of early treatment may prevent development of Eustachian tube dysfunction and TM changes in patients with AR

Ferroelectric photovoltaic properties in doubly substituted (Bi0.9La0.1)(Fe0.97Ta0.03)O3 thin films

This work was supported by the DOE-EPSCoR Grant No. DE-FG02-08ER46526. Acknowledgment is also due to NSF Grant No. #1002410 for providing fellowships to R.K.K., D.B., and J.S.Y.Doubly substituted [Bi0.9La0.1][Fe0.97Ta0.03]O3 (BLFTO) films were fabricated on Pt/TiO2/SiO2/Si substrates by pulsed laser deposition. The ferroelectric photovoltaic properties of ZnO:Al/BLFTO/Pt thin film capacitor structures were evaluated under white light illumination. The open circuit voltage and short circuit current density were observed to be ∼0.20 V and ∼1.35 mA/cm2, respectively. The band gap of the films was determined to be ∼2.66 eV, slightly less than that of pure BiFeO3 (2.67 eV). The PVproperties of BLFTO thin films were also studied for various pairs of planar electrodes in different directions in polycrystalline thin films.Publisher PDFPeer reviewe

Cyclin D1 integrates G9a-mediated histone methylation.

Lysine methylation of histones and non-histone substrates by the SET domain containing protein lysine methyltransferase (KMT) G9a/EHMT2 governs transcription contributing to apoptosis, aberrant cell growth, and pluripotency. The positioning of chromosomes within the nuclear three-dimensional space involves interactions between nuclear lamina (NL) and the lamina-associated domains (LAD). Contact of individual LADs with the NL are dependent upon H3K9me2 introduced by G9a. The mechanisms governing the recruitment of G9a to distinct subcellular sites, into chromatin or to LAD, is not known. The cyclin D1 gene product encodes the regulatory subunit of the holoenzyme that phosphorylates pRB and NRF1 thereby governing cell-cycle progression and mitochondrial metabolism. Herein, we show that cyclin D1 enhanced H3K9 dimethylation though direct association with G9a. Endogenous cyclin D1 was required for the recruitment of G9a to target genes in chromatin, for G9a-induced H3K9me2 of histones, and for NL-LAD interaction. The finding that cyclin D1 is required for recruitment of G9a to target genes in chromatin and for H3K9 dimethylation, identifies a novel mechanism coordinating protein methylation