Building capacity for dissemination and implementation research: One university’s experience

Abstract Background While dissemination and implementation (D&I) science has grown rapidly, there is an ongoing need to understand how to build and sustain capacity in individuals and institutions conducting research. There are three inter-related domains for capacity building: people, settings, and activities. Since 2008, Washington University in St. Louis has dedicated significant attention and resources toward building D&I research capacity. This paper describes our process, challenges, and lessons with the goal of informing others who may have similar aims at their own institution. Activities An informal collaborative, the Washington University Network for Dissemination and Implementation Research (WUNDIR), began with a small group and now has 49 regular members. Attendees represent a wide variety of settings and content areas and meet every 6 weeks for half-day sessions. A logic model organizes WUNDIR inputs, activities, and outcomes. A mixed-methods evaluation showed that the network has led to new professional connections and enhanced skills (e.g., grant and publication development). As one of four, ongoing, formal programs, the Dissemination and Implementation Research Core (DIRC) was our first major component of D&I infrastructure. DIRC’s mission is to accelerate the public health impact of clinical and health services research by increasing the engagement of investigators in later stages of translational research. The aims of DIRC are to advance D&I science and to develop and equip researchers with tools for D&I research. As a second formal component, the Washington University Institute for Public Health has provided significant support for D&I research through pilot projects and a small grants program. In a third set of formal programs, two R25 training grants (one in mental health and one in cancer) support post-doctoral scholars for intensive training and mentoring in D&I science. Finally, our team coordinates closely with D&I functions within research centers across the university. We share a series of challenges and potential solutions. Conclusion Our experience in developing D&I research at Washington University in St. Louis shows how significant capacity can be built in a relatively short period of time. Many of our ideas and ingredients for success can be replicated, tailored, and improved upon by others

Training scholars in dissemination and implementation research for cancer prevention and control: A mentored approach

Abstract Background As the field of D&I (dissemination and implementation) science grows to meet the need for more effective and timely applications of research findings in routine practice, the demand for formalized training programs has increased concurrently. The Mentored Training for Dissemination and Implementation Research in Cancer (MT-DIRC) Program aims to build capacity in the cancer control D&I research workforce, especially among early career researchers. This paper outlines the various components of the program and reports results of systematic evaluations to ascertain its effectiveness. Methods Essential features of the program include selection of early career fellows or more experienced investigators with a focus relevant to cancer control transitioning to a D&I research focus, a 5-day intensive training institute, ongoing peer and senior mentoring, mentored planning and work on a D&I research proposal or project, limited pilot funding, and training and ongoing improvement activities for mentors. The core faculty and staff members of the MT-DIRC program gathered baseline and ongoing evaluation data regarding D&I skill acquisition and mentoring competency through participant surveys and analyzed it by iterative collective reflection. Results A majority (79%) of fellows are female, assistant professors (55%); 59% are in allied health disciplines, and 48% focus on cancer prevention research. Forty-three D&I research competencies were assessed; all improved from baseline to 6 and 18 months. These effects were apparent across beginner, intermediate, and advanced initial D&I competency levels and across the competency domains. Mentoring competency was rated very highly by the fellows––higher than rated by the mentors themselves. The importance of different mentoring activities, as rated by the fellows, was generally congruent with their satisfaction with the activities, with the exception of relatively greater satisfaction with the degree of emotional support and relatively lower satisfaction for skill building and opportunity initially. Conclusions These first years of MT-DIRC demonstrated the program’s ability to attract, engage, and improve fellows’ competencies and skills and implement a multicomponent mentoring program that was well received. This account of the program can serve as a basis for potential replication and evolution of this model in training future D&I science researchers

<i>d</i>-wave superconductivity from electron-phonon interactions

I examine electron-phonon mediated superconductivity in the intermediate coupling and phonon frequency regime of the quasi-two-dimensional Holstein model. I use an extended Migdal-Eliashberg theory that includes vertex corrections and spatial fluctuations. I find a d-wave superconducting state that is unique close to half filling. The order parameter undergoes a transition to s-wave superconductivity on increasing filling. I explain how the inclusion of both vertex corrections and spatial fluctuations is essential for the prediction of a d-wave order parameter. I then discuss the effects of a large Coulomb pseudopotential on the superconductivity (such as is found in contemporary superconducting materials like the cuprates), which results in the destruction of the s-wave states, while leaving the d-wave states unmodified

Steady compressible vortex flows: the hollow-core vortex array

We examine the effects of compressiblity on the structure of a single row of hollowcore, constant-pressure vortices. The problem is formulated and solved in the hodograph plane. The transformation from the physical plane to the hodograph plane results in a linear problem that is solved numerically. The numerical solution is checked via a Rayleigh-Janzen expansion. It is observed that for an appropriate choice of the parameters M[infty infinity] = q[infty infinity]/c[infty infinity], and the speed ratio, a = q[infty infinity]/qv, where qv is the speed on the vortex boundary, transonic shock-free flow exists. Also, for a given fixed speed ratio, a, the vortices shrink in size and get closer as the Mach number at infinity, M[infty infinity], is increased. In the limit of an evacuated vortex core, we find that all such solutions exhibit cuspidal behaviour corresponding to the onset of limit lines

On steady compressible flows with compact vorticity; the compressible Stuart vortex

Numerical and analytical solutions to the steady compressible Euler equations corresponding to a compressible analogue of the linear Stuart vortex array are presented. These correspond to a homentropic continuation, to finite Mach number, of the Stuart solution describing a linear vortex array in an incompressible fluid. The appropriate partial differential equations describing the flow correspond to the compressible homentropic Euler equations in two dimensions, with a prescribed vorticity–density–streamfunction relationship. In order to construct a well-posed problem for this continuation, it was found, unexpectedly, to be necessary to introduce an eigenvalue into the vorticity–density–streamfunction equation. In the Rayleigh–Janzen expansion of solutions in even powers of the free-stream Mach number M[infty infinity], this eigenvalue is determined by a solvability condition. Accurate numerical solution by both finite-difference and spectral methods are presented for the compressible Stuart vortex, over a range of M[infty infinity], and of a parameter corresponding to a confined mass-flow rate. These also confirm the nonlinear eigenvalue character of the governing equations. All solution branches followed numerically were found to terminate when the maximum local Mach number just exceeded unity. For one such branch we present evidence for the existence of a very small range of M[infty infinity] over which smooth transonic shock-free flow can occur