119 research outputs found
Neural Working Memory Changes During a Spaceflight Analog With Elevated Carbon Dioxide: A Pilot Study
Spaceflight missions to the International Space Station (ISS) expose astronauts to
microgravity, radiation, isolation, and elevated carbon dioxide (CO₂), among other
factors. Head down tilt bed rest (HDBR) is an Earth-based analog for spaceflight used to
study body unloading, fluid shifts, and other factors unrelated to gravitational changes.
While in space, astronauts need to use mental rotation strategies to facilitate their
adaptation to the ISS environment. Therefore, spatial working memory is essential for
crewmember performance. Although the effects of HDBR on spatial working memory
have recently been studied, the results are still inconclusive. Here, we expand upon
past work and examine the effects of HDBR with elevated CO₂ (HDBR + CO₂) on
brain activation patterns during spatial working memory performance. In addition,
we compare brain activation between 30 days of HDBR + CO₂ and 70 days of
HDBR to test the isolated effect of CO₂. Eleven subjects (6 males, 5 females; mean
age = 34 ± 8 years) underwent six functional magnetic resonance imaging (fMRI)
sessions pre-, during, and post-HDBR + CO₂. During the HDBR + CO₂ intervention,
we observed decreasing activation in the right middle frontal gyrus and left regions of
the cerebellum, followed by post-intervention recovery. We detected several correlations
between brain and behavioral slopes of change with the HDBR + CO₂ intervention.
For example, greater increases in activation in frontal, temporal and parietal regions
were associated with larger spatial working memory improvements. Comparing the
HDBR + CO₂ group to data from our previous 70-day HDBR study, we found greater
decreases in activation in the right hippocampus and left inferior temporal gyrus for
the HDBR + CO₂ group over the course of the intervention. Together, these findings
increase our understanding of the neural mechanisms of HDBR, elevated levels of CO₂
and spaceflight-related changes in spatial working memory performance
Application of numerical methods in the study operational characteristics of the combustion chamber (pumping unit GPA-16U) at different loads
We report on X-ray resonance exchange and neutron scattering of metallic GdS. At the
LII and LIII absorption edges of Gd, resonance enhancements of more than two orders of magnitude over the non-resonant magnetic scattering are observed. Polarisation analysis proves that these enhancements are due to dipolar transitions from the 2p to the 5d states. The branching ratio between the LII and LIII edges of 2.5 suggests a polarisation of the 5d electrons in the ground state. The antiferromagnetic order is of type II in the fcc lattice. Single crystal diffraction of hot neutrons suggests that the spin direction lies within the (111) planes with a value for the sublattice magnetisation of 6.51(3) . The critical exponent for the sublattice magnetisation has a value of in agreement with a pure Heisenberg model. Above TN, a sharp component persists in the critical diffuse scattering. Lattice distortions give indications for two additional low-temperature phase transitions at about 49 K and 32 K. We
argue that these transitions are not connected to spin reorientations and discuss the possible
influence of fourth-order exchange interactions
The Impact of 6 and 12 Months in Space on Human Brain Structure and Intracranial Fluid Shifts
As plans develop for Mars missions, it is important to understand how long-duration spaceflight impacts brain health. Here
we report how 12-month (n = 2 astronauts) versus 6-month (n = 10 astronauts) missions impact brain structure and fluid
shifts. We collected MRI scans once before flight and four times after flight. Astronauts served as their own controls; we
evaluated pre- to postflight changes and return toward preflight levels across the 4 postflight points. We also provide data to
illustrate typical brain changes over 7 years in a reference dataset. Twelve months in space generally resulted in larger
changes across multiple brain areas compared with 6-month missions and aging, particularly for fluid shifts. The majority of
changes returned to preflight levels by 6 months after flight. Ventricular volume substantially increased for 1 of the
12-month astronauts (left: +25%, right: +23%) and the 6-month astronauts (left: 17 ± 12%, right: 24 ± 6%) and exhibited little
recovery at 6 months. Several changes correlated with past flight experience; those with less time between subsequent missions had larger preflight ventricles and smaller ventricular volume increases with flight. This suggests that spaceflight-induced
ventricular changes may endure for long periods after flight. These results provide insight into brain changes that occur with longduration spaceflight and demonstrate the need for closer study of fluid shift
Neural Correlates of Vestibular Processing During a Spaceflight Analog With Elevated Carbon Dioxide (CO₂): A Pilot Study
Astronauts return to Earth from spaceflight missions with impaired mobility and balance;
recovery can last weeks postflight. This is due in large part to the altered vestibular
signaling and sensory reweighting that occurs in microgravity. The neural mechanisms
of spaceflight-induced vestibular changes are not well understood. Head-down-tilt bed
rest (HDBR) is a common spaceflight analog environment that allows for study of
body unloading, fluid shifts, and other consequences of spaceflight. Subjects in this
context still show vestibular changes despite being in Earth’s gravitational environment,
potentially due to sensory reweighting. Previously, we found evidence of sensory
reweighting and reduced neural efficiency for vestibular processing in subjects who
underwent a 70-day HDBR intervention. Here we extend this work by evaluating the
impact of HDBR paired with elevated carbon dioxide (CO₂) to mimic International
Space Station conditions on vestibular neural processing. Eleven participants (6 males,
34 ± 8 years) completed 30 days of HDBR combined with 0.5% atmospheric CO₂
(HDBR + CO₂). Participants underwent six functional magnetic resonance imaging
(fMRI) sessions pre-, during, and post- HDBR + CO₂ while we measured brain activity
in response to pneumatic skull taps (a validated method of vestibular stimulation). We
also measured mobility and balance performance several times before and after the
intervention. We found support for adaptive neural changes within the vestibular system
during bed rest that subsequently recovered in several cortical and cerebellar regions.
Further, there were multiple brain regions where greater pre- to post- deactivation was
associated with reduced pre- to post- balance declines. That is, increased deactivation
of certain brain regions associated with better balance post-HDBR + CO₂. We also
found that, compared to HDBR alone (n = 13 males; 29 ± 3 years) HDBR + CO₂ is
associated with greater increases in activation of multiple frontal, parietal, and temporal
regions during vestibular stimulation. This suggests interactive or additive effects of bed
rest and elevated CO₂. Finally, we found stronger correlations between pre- to postHDBR + CO₂ brain changes and dependence on the visual system during balance
for subjects who developed signs of Spaceflight-Associated Neuro-ocular Syndrome
Frontiers in Systems Neuroscience | www.frontiersin.org 1 January 2020 | Volume 13 | Article 80Hupfeld et al. Neural Vestibular Processing With HDBR + CO₂
(SANS). Together, these findings have clear implications for understanding the neural
mechanisms of bed rest and spaceflight-related changes in vestibular processing, as
well as adaptation to altered sensory inputs
Reversible Control of Magnetic Interactions by Electric Field in a Single Phase Material
Intrinsic magnetoelectric coupling describes the interaction between magnetic
and electric polarization through an inherent microscopic mechanism in a single
phase material. This phenomenon has the potential to control the magnetic state
of a material with an electric field, an enticing prospect for device
engineering. We demonstrate 'giant' magnetoelectric cross-field control in a
single phase rare earth titanate film. In bulk form, EuTiO3 is
antiferromagnetic. However, both anti and ferromagnetic interactions coexist
between different nearest neighbor europium ions. In thin epitaxial films,
strain can be used to alter the relative strength of the magnetic exchange
constants. Here, we not only show that moderate biaxial compression
precipitates local magnetic competition, but also demonstrate that the
application of an electric field at this strain state, switches the magnetic
ground state. Using first principles density functional theory, we resolve the
underlying microscopic mechanism resulting in the EuTiO3 G-type magnetic
structure and illustrate how it is responsible for the 'giant' cross-field
magnetoelectric effect
Retrospective review of superficial femoral artery stenting in diabetic patients: thiazolidinedione use may decrease reinterventions
Mindfulness and Self-compassion as Unique and Common Predictors of Affect in the General Population
Bioprocessing strategies for the large-scale production of human mesenchymal stem cells: a review
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