SIT 45: An interacting, compact, and star-forming isolated galaxy triplet

Acknowledgements. We thank our referee whose valuable comments have certainly contributed to improve and clarify this paper. MAF and PVB acknowledge financial support by the DI-PUCV research project 039.481/2020. MAF also acknowledges support from FONDECYT iniciación project 11200107 and the Emergia program (EMERGIA20_38888) from Consejería de Transformación Económica, Industria, Conocimiento y Universidades and University of Granada. UL and DE acknowledge support from project PID2020-114414GB- 100, financed by MCIN/AEI/10.13039/501100011033. DE also acknowledges support from Beatriz Galindo senior fellowship (BG20/00224) financed by the Spanish Ministry of Science and Innovation, and project PID2020-114414GB- 100 financed by MCIN/AEI/10.13039/501100011033. UL, SV and DE acknowledge support from project P20_00334 financed by the Junta de Andalucía and from FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/Proyecto A-FQM-510-UGR20. MB gratefully acknowledges support by the ANID BASAL project FB210003 and from the FONDECYT regular grant 1211000. SDP is grateful to the Fonds de Recherche du Québec – Nature et Technologies and acknowledges financial support from the Spanish Ministerio de Economía y Competitividad under grants AYA2016-79724-C4-4-P and PID2019-107408GB-C44, from Junta de Andalucía Excellence Project P18-FR-2664, and also acknowledges support from the State Agency for Research of the Spanish MCIU through the ‘Center of Excellence Severo Ochoa’ award for the Instituto de Astrofísica de Andalucía (SEV-2017-0709). This research made use of Astropy, a community-developed core Python (http://www.python.org) package for Astronomy (Astropy Collaboration 2013); Ipython (Pérez & Granger 2007); Matplotlib (Hunter 2007); Numpy (Walt et al. 2011); Scipy (Jones et al. 2001); and Topcat (Taylor 2005). This research made use of Astrodendro, a Python package to compute dendrograms of Astronomical data (http:// www.dendrograms.org/). This research has made use of the NASA/IPAC Extragalactic Database, operated by the Jet Propulsion Laboratory of the California Institute of Technology, un centract with the National Aeronautics and Space Administration. Funding for SDSS-III has been provided by the Alfred P. Sloan Foundation, the Participating Institutions, the National Science Foundation, and the U.S. Department of Energy O ce of Science. The SDSS-III Web site is http://www.sdss3.org/. The SDSS-IV site is http://www.sdss. org. Based on observations made with the NASA Galaxy Evolution Explorer (GALEX). GALEX is operated for NASA by the California Institute of Technology under NASA contract NAS5-98034. This publication makes use of data products from the Wide-field Infrared Survey Explorer, which is a joint project of the University of California, Los Angeles, and the Jet Propulsion Laboratory /California Institute of Technology, funded by the National Aeronautics and Space Administration.Context. The underlying scenario of the formation and evolution of galaxy triplets is still uncertain. Mergers of galaxies in isolated triplets give us the opportunity to study the already complex merging process, with minimal contamination of other environmental effects that potentially allow and accelerate galaxy transitions from active star-forming to passive galaxies. Aims. The merging system SIT 45 (UGC 12589) is one of 315 systems in the SDSS-based catalogue of Isolated Triplets (SIT); it is an unusual isolated galaxy triplet, consisting of three merging late-type galaxies. The main aims of this work are to study the dynamical evolution and star formation history (SFH) of SIT 45, as well as its dependence on its local and large-scale environment. Methods. To study its dynamics, parameters such as the velocity dispersion (σv), the harmonic radius (RH), the crossing time (H0tc), and the virial mass (Mvir), along with the compactness of the triplet (S) were considered. To investigate the possible dependence of these dynamical parameters on the environment, the tidal force Q parameters (both local and large-scale) and the projected local density (ηk) were used. To constrain the SFH, we used CIGALE to fit its observed spectral energy distribution using multiwavelength data from the ultraviolet to the infrared. Results. SIT 45 is one of the most compact triplets in the SIT, and it is also more compact than triplets in other samples. According to its SFH, SIT 45 presents star formation, where the galaxies also present recent (∼200 Myr) star formation increase, indicating that this activity may have been triggered by the interaction. Its dynamical configuration suggests that the system is highly evolved in comparison to the SIT. However, this is not expected for systems composed of star-forming late-type galaxies, based on observations in compact groups. Conclusions. We conclude that SIT 45 is a system of three interacting galaxies that are evolving within the same dark matter halo; its compact configuration is a consequence of the ongoing interaction rather than being due to a long-term evolution (as suggested from its H0tc value). We consider two scenarios for the present configuration of the triplet, one where one of the members is a tidal galaxy, and another where this galaxy arrives to the system after the interaction. Both scenarios need further exploration. The isolated triplet SIT 45 is therefore an ideal system to study short timescale mechanisms (∼108 yr), such as starbursts triggered by interactions which are more frequent at higher redshift.DI-PUCV research project 039.481/2020FONDECYT iniciación project 11200107Emergia program (EMERGIA20_38888) from Consejería de Transformación Económica, Industria, Conocimiento y UniversidadesUniversity of GranadaProject PID2020-114414GB- 100, financed by MCIN/AEI/10.13039/501100011033Senior fellowship (BG20/00224) financed by the Spanish Ministry of Science and InnovationProject PID2020-114414GB- 100 financed by MCIN/AEI/10.13039/501100011033Project P20_00334 financed by the Junta de Andalucía and from FEDER/Junta de Andalucía-Consejería de Transformación Económica, Industria, Conocimiento y Universidades/Proyecto A-FQM-510-UGR20ANID BASAL project FB210003FONDECYT regular grant 1211000Fonds de Recherche du Québec – Nature et TechnologiesSpanish Ministerio de Economía y Competitividad under grants AYA2016-79724-C4-4-P and PID2019-107408GB-C44Junta de Andalucía Excellence Project P18-FR-2664State Agency for Research of the Spanish MCIU through the ‘Center of Excellence Severo Ochoa’ award for the Instituto de Astrofísica de Andalucía (SEV-2017-0709

In silico drug repurposing for the identification of potential candidate molecules against arboviruses infection

Arboviral diseases caused by dengue (DENV), Zika (ZIKV) and chikungunya (CHIKV) viruses represent a major public health problem worldwide, especially in tropical areas where millions of infections occur every year. The aim of this research was to identify candidate molecules for the treatment of these diseases among the drugs currently available in the market, through in silico screening and subsequent in vitro evaluation with cell culture models of DENV and ZIKV infections. Numerous pharmaceutical compounds from antibiotics to chemotherapeutic agents presented high in silico binding affinity for the viral proteins, including ergotamine, antrafenine, natamycin, pranlukast, nilotinib, itraconazole, conivaptan and novobiocin. These five last compounds were tested in vitro, being pranlukast the one that exhibited the best antiviral activity. Further in vitro assays for this compound showed a significant inhibitory effect on DENV and ZIKV infection of human monocytic cells and human hepatocytes (Huh-7 cells) with potential abrogation of virus entry. Finally, intrinsic fluorescence analyses suggest that pranlukast may have some level of interaction with three viral proteins of DENV: envelope, capsid, and NS1. Due to its promising results, suitable accessibility in the market and reduced restrictions compared to other pharmaceuticals; the anti-asthmatic pranlukast is proposed as a drug candidate against DENV, ZIKV, and CHIKV, supporting further in vitro and in vivo assessment of the potential of this and other lead compounds that exhibited good affinity scores in silico as therapeutic agents or scaffolds for the development of new drugs against arboviral diseases. © 2019 Elsevier B.V.Universidad Tecnológica de Pereira, UTP: TRFCI-1P2016 National Institutes of Health, NIH National Institutes of Health, NIH: R01 AI24493 Department of Science, Information Technology and Innovation, Queensland Government, DSITI: 811-2018 Universidad Autónoma de Bucaramanga, UNABThe authors wish to thank the Administrative Department of Science, Technology and Innovation of Colombia [Grant: Colciencias No. 811-2018 ], Universidad Nacional Autónoma de México [Grant: Programa de Becas Posdoctorales en la UNAM 2016 ], Universidad Tecnológica de Bolívar [Grant: TRFCI-1P2016 ] and the National Institutes of Health [NIH grant R01 AI24493 ] for their financial support. Appendix AA continuación se relacionan los compuestos químicos y su número de registro CAS (Chemical Abstracts Service) antrafenine, 55300-29-3; conivaptan, 168626-94-6, 210101-16-9; ergotamine, 113-15-5, 52949-35-6; itraconazole, 84625-61-6; natamycin, 52882-37-8, 7681-93-8; nilotinib, 641571-10-0; novobiocin, 1476-53-5, 303-81-1, 39301-00-3, 4309-70-0; pranlukast, 103177-37-

Avifauna diversity assessment in the Communal Natural Protected Area El Gavilán, Central Coast of Oaxaca, Mexico

Tropical dry forest (TDF) is an ecosystem with a pronounced seasonality and high animal diversity. It is threatened by a wide variety of anthropogenic activities such as human population growth, deforestation rate, tourism development, forest fires, overhunting, and wildlife trade. One of the strategies for this biodiversity conservation is the creation of Communal Natural Protected Areas (CNPA), which are poorly explored. The aim of this study was to supply an assessment of the avian diversity in the CNPA El Gavilán on the Central Coast of Oaxaca (Mexico) during two seasons (dry and rainy). Sampling has been carried out at two localities (named as Centre and Mountain) between November 2018 and September 2019, using a point count method. At each locality, we sampled one transect varying in length, but with five-point counts separated by a minimum of 200 m. We made monthly two visits per transect. Birds were counted from a fixed raising position within a circle of 50-m radius for a specific period (10 min.) at every point. In total, 85 species were recorded, which belong to 65 genera, 24 families, and 13 orders. The most representative order was Passeriformes with 53 species. Most species (83) were considered very rare, and two species (Aratinga canicularis and Calocitta formosa) were rare. Regarding the avian diversity, 0D, the Centre locality had 74 species (19 exclusive species), while the Mountain locality had 65 species (11 exclusive species). The dry season had a higher diversity (Hʹ = 3.44) than the rainy season (Hʹ= 3.41), but there were no significant differences (Hutcheson t = 0.365, d.f. = 1, p > 0.05). Eighty-two percent (70 species) were considered residents, 15.3% (13 species) were winter migrants, 1.2% (one species) were summer migrants, and 1.2% (one species) were transient. Of the total registered taxa, 50 species were principally insectivorous, 14 species were grain-frugivorous, eight species were omnivorous, six species were carnivorous, and six species were nectarivorous. The avifauna of CNPA El Gavilán shows that a marked effect does not exist in the species composition between seasons. Due to the species richness recorded and estimated there, the study area should be considered in conservation policies, particularly because this territory is under intense pressure due to changes in land use

SIT 45: An interacting, compact, and star-forming isolated galaxy triplet

The merging system SIT 45 (UGC 12589) is an unusual isolated galaxy triplet, consisting of three merging late-type galaxies, out of 315 systems in the SIT (SDSS-based catalogue of Isolated Triplets). The main aims of this work are to study its dynamical evolution and star formation history (SFH), as well as its dependence on its local and large-scale environment. To study its dynamics, parameters such as the velocity dispersion ($\sigma_{v}$), the harmonic radius ($R_{H}$), the crossing time ($H_0t_c$), and the virial mass ($M_{vir}$), along with the compactness of the triplet ($S$) were considered. To constrain the SFH, we used CIGALE to fit its observed spectral energy distribution using multi-wavelength data from the ultraviolet to the infrared. According to its SFH, SIT 45 presents star-formation, where the galaxies also present recent ($\sim$200 Myr) star-formation increase, indicating that this activity may have been triggered by the interaction. Its dynamical configuration suggests that the system is highly evolved in comparison to the SIT. However this is not expected for systems composed of star-forming late-type galaxies, based on observations in compact groups. We conclude that SIT 45 is a system of three interacting galaxies that are evolving within the same dark matter halo, where its compact configuration is a consequence of the on-going interaction, rather than due to a long-term evolution (as suggested from its $H_0t_c$ value). We consider two scenarios for the present configuration of the triplet, one where one of the members is a tidal galaxy, and another where this galaxy arrives to the system after the interaction. Both scenarios need further exploration. The isolated triplet SIT 45 is therefore an ideal system to study short timescale mechanisms ($\sim 10^8$ years), such as starbursts triggered by interactions which are more frequent at higher redshift.Comment: 13 pages, 7 figures, accepted for publication in Astronomy & Astrophysic

Los Métodos Y Procesos Multicriterio Para La Evaluación

El presente artículo tiene por objeto evidenciar las bondades que el método multicriterio otorga en las evaluaciones científicas que sean consistentes con un marco de racionalidad. Inicia haciendo referencia al método científico a través del cual el hombre trata de entender el mundo, construyendo uno artificial desde la ciencia. A continuación se reflexiona sobre el valor agregado que pueden proporcionar los métodos cualitativos al entregar una visión diferente del mundo, al tomar en consideración variables que no pueden ser expresadas cuantitativamente. Para finalizar se expone el método multicriterio como una herramienta útil para determinar el impacto de acciones a desarrollo sobre la sostenibilidad al incorporar los conflictos que existen entre objetivos económicos, ambientales y sociales, y entre distintos niveles de decisión en las evaluaciones científicas.AbstractThis article aims to make clear the benefits the multicriteriamethod gives to scientific assessment which are consistent with a rationality framework. It begins by referring to the scientific method, through which humankind tries to understand the world building an artificial world from science. Afterwards a reflection on the added value qualitative methods as a methodology can give, is presented since they allow a broader worldview by taking into account variables that cannot be expressed quantitatively. Finally, a multicriteria-method is presented as a useful tool to determine the impact of actions on sustainability, while incorporating the existing conflicts between economic, environmental and social objectives, and between different levels of decision making in scientific assessment.El presente artículo tiene por objeto evidenciar las bondades que el método multicriterio otorga en las evaluaciones científicas que sean consistentes con un marco de racionalidad. Inicia haciendo referencia al método científico a través del cual el hombre trata de entender el mundo, construyendo uno artificial desde la ciencia. A continuación se reflexiona sobre el valor agregado que pueden proporcionar los métodos cualitativos al entregar una visión diferente del mundo, al tomar en consideración variables que no pueden ser expresadas cuantitativamente. Para finalizar se expone el método multicriterio como una herramienta útil para determinar el impacto de acciones a desarrollo sobre la sostenibilidad al incorporar los conflictos que existen entre objetivos económicos, ambientales y sociales, y entre distintos niveles de decisión en las evaluaciones científicas.AbstractThis article aims to make clear the benefits the multicriteriamethod gives to scientific assessment which are consistent with a rationality framework. It begins by referring to the scientific method, through which humankind tries to understand the world building an artificial world from science. Afterwards a reflection on the added value qualitative methods as a methodology can give, is presented since they allow a broader worldview by taking into account variables that cannot be expressed quantitatively. Finally, a multicriteria-method is presented as a useful tool to determine the impact of actions on sustainability, while incorporating the existing conflicts between economic, environmental and social objectives, and between different levels of decision making in scientific assessment

An important role for CD4 + T cells in adaptive immunity to Toxoplasma gondii in mice lacking the transcription factor Batf3

Immunity t

The Large Aperture GRB Observatory

The Large Aperture GRB Observatory (LAGO) is aiming at the detection of the high energy (around 100 GeV) component of Gamma Ray Bursts, using the single particle technique in arrays of Water Cherenkov Detectors (WCD) in high mountain sites (Chacaltaya, Bolivia, 5300 m a.s.l., Pico Espejo, Venezuela, 4750 m a.s.l., Sierra Negra, Mexico, 4650 m a.s.l). WCD at high altitude offer a unique possibility of detecting low gamma fluxes in the 10 GeV - 1 TeV range. The status of the Observatory and data collected from 2007 to date will be presented.Comment: 4 pages, proceeding of 31st ICRC 200

Water Cherenkov Detectors response to a Gamma Ray Burst in the Large Aperture GRB Observatory

In order to characterise the behaviour of Water Cherenkov Detectors (WCD) under a sudden increase of 1 GeV - 1 TeV background photons from a Gamma Ray Burst (GRB), simulations were conducted and compared to data acquired by the WCD of the Large Aperture GRB Observatory (LAGO). The LAGO operates arrays of WCD at high altitude to detect GRBs using the single particle technique. The LAGO sensitivity to GRBs is derived from the reported simulations of the gamma initiated particle showers in the atmosphere and the WCD response to secondaries.Comment: 5 pages, proceeding of the 31st ICRC 200