INVESTIGATION OF THE INFLUENCE OF CONDITIONS FOR THE SYNTHESIS OF CERIUM DIOXIDE-BASED POWDER DOPED GADOLINIUM BY CONTROLLED DOUBLE-JET DEPOSITION

In this work, the characteristics of cerium-based powders stabilized with gadolinium obtained using the controlled double-jet deposition method were investigated. As a result, the conditions for the synthesis of the highest quality powder were determined.Выражаю благодарность Галиаскаровой Марие Равилевне за ценные советы при планировании исследования и рекомендации

Experimental Substantiation of the Possibility to Use Finite Cell Line CHO-K1 for Determination of Specific Activity of Components of Chemical Cholera Vaccine

Objective was to experimentally substantiate the possibility to use the finite cell line CHO-K1 for measuring specific activity of cholera toxin and component of the vaccine choleragen-anatoxin in the process of chemical cholera vaccine manufacturing. Materials and methods. The studies involved the finite cell line CHO-K. The registration of results of bio-indication method was performed visually with the help of inverted microscope and photometrically - in colorimetric test for the assessment of metabolic activity of the cells at the wave length of 595 nm. Results and discussion. The proposed method allows for determining the toxin-production activity of Vibrio cholerae 569B strain during submerged cultivation in bioreactor and specific activity of choleragen-anatoxin by anatoxin binding measuring using cell cultures. The results correlate with the data obtained using intradermal Craig’s technique, GM1-ELISA and radial passive immune hemolysis (RPIH). Introduction of cell culture method into practice will provide for significant decrease in the volumes of usage of animals at the stages of manufacturing of chemical bivalent cholera vaccine

Depressions in patients with essential hypertension complicated by chronic heart failure

Depressive disorders were detected in 48 (63.2%) of 76 patients (70 women and 6 men) with essential hypertension complicated by diastolic heart failure. The quality of life and the degree of chronic heart failure and depressive disorders were estimated at the inclusion of the patients into the study and then 3 months after therapy with the antidepressant pyrazidole. Moderate depressive disorders reduced exercise tolerance. The degree of depressive disorders was found to be directly related to worse quality of life. During combination psychotropic and basic treatment, there were improvements in the characteristics of physical and mental status and in quality of life in the patients

AFFECTIVE DISORDERS IN PATIENTS WITH DIASTOLIC CHRONIC HEART FAILURE

The study assessed the effects of psychotropic therapy on quality of life (QoL) among patients with diastolic chronic heart failure (CHF) and concomitant affective disorders. In total, 76 patients (70 women, 6 men) were examined; in 48, anxiety and depressive disorders were observed. All participants underwent the assessment of QoL, physical functioning and affective disorder severity at baseline and 3 months after the start of the therapy. The antidepressant therapy was associated with improved physical and psychological status, as well as with improved health-related QoL

Disjunct habitat of cryptic Terebellides (Annelida, Trichobranchidae) species shows a phylogenetic link between polychaetes from the White and the North Seas

Abstract Understanding the distribution and biodiversity of marine species is crucial for developing effective conservation strategies and maintaining the health of global ecosystems. Advancements in molecular data utilization have significantly improved our understanding of biodiversity within the genus Terebellides. In this study, we conducted a phylogenetic analysis on polychaete samples from the Kandalaksha Bay, White Sea, revealing their affiliation with a putative undescribed species of the genus Terebellides found in two locations of the North Sea. Interestingly, this species was not detected in the Norwegian and Barents Seas, leading us to propose a disjunct distribution scenario for this Terebellides species. This unique distribution pattern might be attributed to the succession of polychaetes by new species, facilitated by the Gulf Stream and a climate change role in driving shifts in species' ranges and altering marine ecosystem dynamics