Publication and patent analysis of European researchers in the field of production technology and manufacturing systems

This paper develops a structured comparison among a sample of European researchers in the field of Production Technology and Manufacturing Systems, on the basis of scientific publications and patents. Researchers are evaluated and compared by a variegated set of indicators concerning (1) the output of individual researchers and (2) that of groups of researchers from the same country. While not claiming to be exhaustive, the results of this preliminary study provide a rough indication of the publishing and patenting activity of researchers in the field of interest, identifying (dis)similarities between different countries. Of particular interest is a proposal for aggregating analysis results by means of maps based on publication and patent indicators. A large amount of empirical data are presented and discusse

A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis

Background: Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin, PEALut, have been found to exert neuroprotective activities in experimental models of spinal and brain injury and Alzheimer disease, as well as a clinical improvement in human stroke patients. Furthermore, PEALut enhances the expression of different myelin proteins in oligodendrocyte progenitor cells suggesting that this composite might have protective effects in MS experimental models. Methods: The mouse model of experimental autoimmune encephalomyelitis (EAE) based on active immunization with a fragment of myelin oligodendrocyte glycoprotein (MOG35-55) was used. The daily assessment of clinical score and the expression of serum amyloid A (SAA1), proinflammatory cytokines TNF-\u3b1, IL-1\u3b2, IFN-\u3b3, and NLRP3 inflammasome, as well as TLR2, Fpr2, CD137, CD3-\u3b3, and TCR-\u3b6 chain, heterodimers that form T cell surface glycoprotein (TCR), and cannabinoid receptors CB1, CB2, and MBP, were evaluated in the brainstem and cerebellum at different postimmunization days (PIDs). Results: Vehicle-MOG35-55-immunized (MOG35-55) mice developed ascending paralysis which peaked several days later and persisted until the end of the experiment. PEALut, given intraperitoneally daily starting on day 11 post-immunization, dose-dependently improved clinical score over the range 0.1-5 mg/kg. The mRNA expression of SAA1, TNF-\u3b1, IL-1\u3b2, IFN-\u3b3, and NLRP3 were significantly increased in MOG35-55 mice at 14 PID. In MOG35-55 mice treated with 5 mg /kg PEALut, the increase of SAA1, TNF- \u3b1, IL-1\u3b2, and IFN-\u3b3transcripts at 14 PID was statistically downregulated as compared to vehicle-MOG35-55 mice (p < 0.05). The expression of TLR2, Fpr2, CD137, CD3-\u3b3, TCR-\u3b6 chain, and CB2 receptors showed a significant upregulation in vehicle-MOG35-55 mice at 14 PID. Instead, CB1 and MBP transcripts have not changed in expression at any time. In MOG/PEALut-treated mice, TLR2, Fpr2, CD137, CD3-\u3b3, TCR-\u3b6 chain, and CB2 mRNAs were significantly downregulated as compared to vehicle MOG35-55 mice. Conclusions: The present results demonstrate that the intraperitoneal administration of the composite PEALut significantly reduces the development of clinical signs in the MOG35-55 model of EAE. The dose-dependent improvement of clinical score induced by PEALut was associated with a reduction in transcript expression of the acute-phase protein SAA1, TNF-\u3b1, IL-1\u3b2, IFN-\u3b3, and NLRP3 proinflammatory proteins and TLR2, Fpr2, CD137, CD3-\u3b3, TCR-\u3b6 chain, and CB2 receptors

Dusty Starbursts and the Growth of Cosmic Structure

Dusty starbursts were more numerous around z~1 than today and appear to be responsible for the majority of cosmic star formation over the Hubble time. We suggest that they represent a common phase within galaxies in general which is triggered by the growth of cosmic structure. We discuss the origin of the luminosity of luminous infrared galaxies at z~1. Are these galaxies dominated by star formation or nuclear activity ? What is triggering their strong activity ? Is it triggered by external interactions or did it happen naturally within isolated galaxies ? We present HST-ACS high resolution optical images of luminous infrared galaxies at z~0.7 showing the evolution of the morphology of these galaxies as a function of infrared luminosity, or star formation rate, and discuss the effect of the environment on their activity.Comment: 4 pages, 2 figures, to appear in Proceeding of the "Multi-Wavelength Cosmology" Conference held in Mykonos, Greece, June 2003, ed.M. Plionis (Kluwer

Experimental comparison of dynamic tracking performanceof iGPS and laser tracker

External metrology systems are increasingly being integrated with traditional industrial articulated robots, especially in the aerospace industries, to improve their absolute accuracy for precision operations such as drilling, machining and jigless assembly. While currently most of the metrology assisted robotics control systems are limited in their position update rate, such that the robot has to be stopped in order to receive a metrology coordinate update, some recent efforts are addressed toward controlling robots using real-time metrology data. The indoor GPS is one of the metrology systems that may be used to provide real-time 6DOF data to a robot controller. Even if there is a noteworthy literature dealing with the evaluation of iGPS performance, there is, however, a lack of literature on how well the iGPS performs under dynamic conditions. This paper presents an experimental evaluation of the dynamic measurement performance of the iGPS, tracking the trajectories of an industrial robot. The same experiment is also repeated using a laser tracker. Besides the experiment results presented, this paper also proposes a novel method for dynamic repeatability comparisons of tracking instrument

Reversible viscosity and Navier--Stokes fluids

Exploring the possibility of describing a fluid flow via a time-reversible equation and its relevance for the fluctuations statistics in stationary turbulent (or laminar) incompressible Navier-Stokes flows.Comment: 7 pages 6 figures, v2: replaced Fig.6 and few changes. Last version: appendix cut shorter, because of a computational erro

MScMS-II: an innovative IR-based indoor coordinate measuring system for large-scale metrology applications

According to the current great interest concerning large-scale metrology applications in many different fields of manufacturing industry, technologies and techniques for dimensional measurement have recently shown a substantial improvement. Ease-of-use, logistic and economic issues, as well as metrological performance are assuming a more and more important role among system requirements. This paper describes the architecture and the working principles of a novel infrared (IR) optical-based system, designed to perform low-cost and easy indoor coordinate measurements of large-size objects. The system consists of a distributed network-based layout, whose modularity allows fitting differently sized and shaped working volumes by adequately increasing the number of sensing units. Differently from existing spatially distributed metrological instruments, the remote sensor devices are intended to provide embedded data elaboration capabilities, in order to share the overall computational load. The overall system functionalities, including distributed layout configuration, network self-calibration, 3D point localization, and measurement data elaboration, are discussed. A preliminary metrological characterization of system performance, based on experimental testing, is also presente

ISOCAM observations in the Lockman Hole - II The 14.3 micron deep survey: data reduction, catalogue and source counts

We present a new analysis of the ISOCAM 14.3 micron deep survey in a 20x20 square arcmins area in the Lockman Hole. This survey is intermediate between the ultra-deep surveys and the shallow surveys in the ELAIS fields. The data have been analyzed with the method presented by Lari et al. (2001). We have produced a catalogue of 283 sources detected above the 5-sigma threshold, with fluxes in the interval 0.1-8 mJy. The catalogue is 90% complete at 1 mJy. The positional accuracy, estimated from the cross-correlation of infrared and optical sources, is around 1.5 arcsec. The search for the optical counterparts of the sources in the survey is performed on a medium-deep r' band optical image (5-sigma depth of r'=25), making use of the radio detections when available. The photometry has been checked through simulations and by comparing the data with those presented in a shallower and more extended ISOCAM survey in the Lockman Hole, that we have presented in a companion paper. Only 15% of the 14.3 micron sources do not have an optical counterpart down to r'=25 mag. We use the 6.7/14.3 micron colour as a star/galaxy separator, together with a visual inspection of the optical image and an analysis of the observed Spectral Energy Distribution of the ISOCAM sources. The stars in the sample turn out to be only 6% of the sample. We discuss the 14.3 micron counts of extragalactic sources, combining our catalogue with that obtained from the shallower ISOCAM survey. The data in the two surveys are consistent, and our results fully support the claims in previous works for the existence of an evolving population of infrared galaxies, confirming the evident departure from non-evolutionary model predictions.Comment: Version accepted by Astronomy and Astrophysics. Images have been heavily degraded to fill the archive size. A full resolution version can be downloaded at the following link http://dipastro.pd.astro.it/giulia/Deep/1252.ps.g