501 research outputs found
Preclinical immunotherapy with Cytokine-Induced Killer lymphocytes against epithelial ovarian cancer
Preclinical immunotherapy with Cytokine-Induced Killer lymphocytes against epithelial ovarian cancer
Despite improvements in surgery and medical treatments, epithelial ovarian cancer (EOC) remains the most lethal gynaecological malignancy. Aim of this study is to investigate the preclinical immunotherapy activity of cytokine-induced killer lymphocytes (CIK) against epithelial ovarian cancers, focusing on platinum-resistant settings. We generated CIK ex vivo starting from human peripheral blood samples (PBMCs) collected from EOC patients. Their antitumor activity was tested in vitro and in vivo against platinum-resistant patient-derived ovarian cancer cells (pdOVCs) and a Patient Derived Xenograft (PDX), respectively. CIK were efficiently generated (48 fold median ex vivo expansion) from EOC patients; pdOVCs lines (n = 9) were successfully generated from metastatic ascites; the expression of CIK target molecules by pdOVC confirmed pre and post treatment in vitro with carboplatin. The results indicate that patient-derived CIK effectively killed autologous pdOVCs in vitro. Such intense activity was maintained against a subset of pdOVC that survived in vitro treatment with carboplatin. Moreover, CIK antitumor activity and tumor homing was confirmed in vivo within an EOC PDX model. Our preliminary data suggest that CIK are active in platinum resistant ovarian cancer models and should be therefore further investigated as a new therapeutic option in this extremely challenging setting
A new limit on the CP violating decay KS -> 3pi0 with the KLOE experiment
We have carried out a new direct search for the CP violating decay KS -> 3pi0
with 1.7 fb^-1 of e+e- collisions collected by the KLOE detector at the
phi-factory DAFNE. We have searched for this decay in a sample of about 5.9 x
10^8 KS KL events tagging the KS by means of the KL interaction in the
calorimeter and requiring six prompt photons. With respect to our previous
search, the analysis has been improved by increasing of a factor four the
tagged sample and by a more effective background rejection of fake KS tags and
spurious clusters. We find no candidates in data and simulated background
samples, while we expect 0.12 standard model events. Normalizing to the number
of KS -> 2pi0 events in the same sample, we set the upper limit on BR(KS ->
3pi0 < 2.6 x 10^-8 at 90% C.L., five times lower than the previous limit. We
also set the upper limit on the eta_000 parameter, |eta_000 | < 0.0088 at 90%
C.L., improving by a factor two the latest direct measurement.Comment: Accepted for publication in Physics Letters B (15 pages, 13 figures
KLOE results in kaon physics and prospects for KLOE-2
The phi-factory DAPHNE offers a possibility to select pure kaon beams,
charged and neutral ones. In particular, neutral kaons from phi->KS KL are
produced in pairs and the detection of a KS (KL) tags the presence of a KL
(KS). This allows to perform precise measurements of kaon properties by means
of KLOE detector. Another advantage of a phi-factory consists in fact that the
neutral kaon pairs are produced in a pure quantum state (J^(PC) = 1^(--)),
which allowsto investigate CP and CPT symmetries via quantum interference
effects, as well as the basic principles of quantum mechanics.A review of the
most recent results of the KLOE experiment at DAPHNE using pure kaon beams or
via quantum interferometry is presented together with prospects for kaon
physics at KLOE-2.Comment: 5 pages, 4 figures, From Phi To Psi 2011 conference, to be published
in Nuclear Physics B (Proceedings Supplements
A High Statistics Search for Electron-Neutrino --> Tau-Neutrino Oscillations
We present new limits on nu_e to nu_tau and nu_e to nu_sterile oscillations
by searching for electron neutrino dissappearance in the high-energy wide-band
CCFR neutrino beam. Sensitivity to nu_tau appearance comes from tau decay modes
in which a large fraction of the energy deposited is electromagnetic. The beam
is composed primarily of muon neutrinos but this analysis uses the 2.3%
electron neutrino component of the beam. Electron neutrino energies range from
30 to 600 GeV and flight lengths vary from 0.9 to 1.4 km. This limit improves
the sensitivity of existing limits and obtains a lowest 90% confidence upper
limit in sin**2(2*alpha) of 9.9 x 10**(-2) at delta-m**2 of 125 eV**2.Comment: submitted to Phys. Rev. D. Rapid Com
Precision measurement of and determination of the contribution to the muon anomaly with the KLOE detector
We have measured the ratio
, with the KLOE detector at DANE for a total integrated
luminosity of 240 pb. From this ratio we obtain the cross section
. From the cross section we determine the
pion form factor and the two-pion contribution to the muon anomaly
for GeV, = . This result confirms the
current discrepancy between the Standard Model calculation and the experimental
measurement of the muon anomaly.Comment: 18 pages, 8 figures, minor text corrections, one table added, version
to appear on Physics Letters
Atmospheric neutrino flux from 3-dimensional simulation
The atmospheric muon and neutrino flux have been simulated using the same
approach which successfully accounted for the recent secondary proton, electron
and positron flux measurements in orbit by the AMS experiment. For the muon
flux, a good agreement is obtained with the CAPRICE and HEAT data for altitudes
ranging from sea level up to about 38 km. The general features of the
calculated atmospheric neutrino flux are reported and discussed. The flux
obtained at the Super-Kamiokande experiment location are reported and compared
with other calculations. For low neutrino energies the flux obtained is
significantly smaller than that used in the data analysis of underground
experiment. The simulation results for the SOUDAN experiment site are also
reported.Comment: 33 pages, 27 figures, 12 tables, final version for Phys. Rev.
Measurement of {\eta} meson production in {\gamma}{\gamma} interactions and {\Gamma}({\eta}-->{\gamma}{\gamma}) with the KLOE detector
We present a measurement of {\eta} meson production in photon-photon
interactions produced by electron-positron beams colliding with \sqrt{s}=1 GeV.
The measurement is done with the KLOE detector at the \phi-factory DA{\Phi}NE
with an integrated luminosity of 0.24 fb^{-1}. The e^+e^- --> e^+e^-{\eta}
cross section is measured without detecting the outgoing electron and positron,
selecting the decays {\eta}-->{\pi}^+{\pi}^-{\pi}^0 and
{\eta}-->{\pi}^0{\pi}^0{\pi}^0. The most relevant background is due to e^+e^-
--> {\eta}{\gamma} when the monochromatic photon escapes detection. The cross
section for this process is measured as {\sigma}(e^+e^- -->{\eta}{\gamma}) =
(856 \pm 8_{stat} \pm 16_{syst}) pb. The combined result for the e^+e^-
-->e^+e^-{\eta} cross section is {\sigma}(e^+e^- -->e^+e^-{\eta}) = (32.72 \pm
1.27_{stat} \pm 0.70_{syst}) pb. From this we derive the partial width
{\Gamma}({\eta}-->{\gamma}{\gamma}) = (520 \pm 20_{stat} \pm 13_{syst}) eV.
This is in agreement with the world average and is the most precise measurement
to date.Comment: Version accepted by JHE
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