Composition and Method for Radiation Synovectomy of Arthritic Joints

Radioactive microspheres for radiation synovectomy of arthritic joints in a mammal comprises a biodegradable glass material and a beta radiation emitting radioisotope chemically dissolved in and distributed substantially uniformly throughout the glass material. The biodegradable glass material may be lithium silicate, lithium aluminosilicate, lithium aluminoborate, lithium germa- nate, lithium aluminogermanate, potassium silicate, potassium aluminosilicate, potassium aluminoborate, potassium germanate or potassium aluminogermanate and the beta radiation emitting radioisotope may be samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 or yttrium-90. Method for preparing such microspheres and for carrying out radiation synovectomy of arthritic joints utilizing such microspheres are also disclosed

Radioactive Glass Microspheres

A radioactive microsphere for radiation therapy of a mammal comprising a biologically compatible glass material containing a beta or gamma emitting radioisotope distributed substantially uniformly throughout the glass. Advantageously, the radioisotope is produced by irradiation of the microsphere

Composition and Method for Radiation Synovectomy of Arthritic Joints

Radioactive microspheres for radiation synovectomy of arithmetic joints in a mammal comprise a biodegradable glass material and a beta radiation emitting radioisotope chemically dissolved in and distributed substantially uniformly throughout the glass material. The biodegradable glass material may be lithium silicate, lithium aluminosilicate, lithium aluminoborate, lithium germa- nate, lithium aluminogermanate, potassium silicate, potassium aluminosilicate, potassium, aluminoborate, potassium germanate or potassium aluminogermanate and the beta radiation emitting radioisotope may be samarium-153, holmium-166, erbium-169, dysprosium-165, rhenium-186, rhenium-188 or yttrium-90. Methods for preparing such microspheres and for carrying out radiation synovectomy of arthritic joints utilizing such microspheres are also disclosed

Glass Microspheres

A radioactive microsphere for radiation therapy of a mammal comprising a biologically compatible glass material containing a beta or gamma emitting radioisotope distributed substantially uniformly throughout the glass. Advantageously, the radioisotope is produced by irradiation of the microsphere

Microspheres for Radiation Therapy

Microspheres for radiation therapy of a mammal which have a non-radioactive isotope which emits beta or gamma radiation of therapeutic intensity upon being irradiated. The microspheres also contain elements which do not become radioactive upon irradiation. The chemical durability of the microspheres is such that they do not release a significant amount of radiation emitting radioisotope into the mammal’s system upon administration. Microspheres containing phosphorus or yttrium; and carbon, nitrogen, fluorine, sodium, magnesium, aluminum, silicon, potassium, vanadium, manganese, gallium, niobium, iodine and/or lead

Composition and Method for Radiation Synovectomy of Arthritic Joints

A method for preparing nonradioactive microspheres adapted for radiation synovectomy of arthritic joints in a mammal involves forming the microspheres by doping a biodegradable glass material which may be lithium or potassium silicate, lithium or potassium aluminosilicate, lithium or potassium aluminoborate, lithium or potassium germanate or lithium or potassium alumino- germanate with an isotope which may be samarium, holmium, erbium, dysprosium, rhemium or yttrium so that the isotope is chemcially dissolved in and distributed uniformly throughout the glass material. The doped glass material is then treated with an acid wash to produce a thin layer on the surface thereof and heat treated to improve the chemical durability of the glass material by rendering the solubility of the layer lower than that of the underlying glass material

Genetic evidence that cellulose synthase activity influences microtubule cortical array organization

To identify factors that influence cytoskeletal organization we screened for Arabidopsis ( Arabidopsis thaliana) mutants that show hypersensitivity to the microtubule destabilizing drug oryzalin. We cloned the genes corresponding to two of the 131 mutant lines obtained. The genes encoded mutant alleles of PROCUSTE1 and KORRIGAN, which both encode proteins that have previously been implicated in cellulose synthesis. Analysis of microtubules in the mutants revealed that both mutants have altered orientation of root cortical microtubules. Similarly, isoxaben, an inhibitor of cellulose synthesis, also altered the orientation of cortical microtubules while exogenous cellulose degradation did not. Thus, our results substantiate that proteins involved in cell wall biosynthesis influence cytoskeletal organization and indicate that this influence on cortical microtubule stability and orientation is correlated with cellulose synthesis rather than the integrity of the cell wall