Prospectus, October 3, 1984

FEMINIST MIND SEEN AS ANSWER FOR WORLD PROBLEMS; PC Digest; Blood Drive successful; \u27Wager opens to rave reviews\u27; 7 senators elected; Staff Profile-Kathy Hubbard Entertainment editor; Reaching mountain top not always goal; Degree still important asset; PC Happenings; Small Business Workshop planned; EMT Workshop scheduled; Parenting programs at Parkland; Health Programs focus on smoking, fitness and skin; Circle K exists to help; Gold struck in Arthur; Responsibility for self is common difficulty; Parkland enrollment follows trend; Woods hosts sports show; Creative Corner...Especially for you!!; The Meaning of I; The Last Goodbye; Advice from the Dueodenum; Almost There; Freedom; Doom-but whose?; Too Big for Me; Lady; The Ballad of Sue and Joe; Love Lost; Climbing the Mountain; Photographer wins in national competition; Student Profile-Carol DeVoss-newly elected senator \u27I\u27d like to see more student participation.\u27 Approximately 200 out of about 8,500 voted; Classifieds; Why are women obsessed?; New shows begin; Campbell\u27s a singin\u27 country boy; September love; Lady Cobras concentrate, win two; Bowlers Pin; IM Volleyball; IM Basketball; IM Football; Cross Country action; Wisdom, age to determine \u2785 Cobras baseball success; Golf actionhttps://spark.parkland.edu/prospectus_1984/1010/thumbnail.jp

The Immune Response to Melanoma Is Limited by Thymic Selection of Self-Antigens

The expression of melanoma-associated antigens (MAA) being limited to normal melanocytes and melanomas, MAAs are ideal targets for immunotherapy and melanoma vaccines. As MAAs are derived from self, immune responses to these may be limited by thymic tolerance. The extent to which self-tolerance prevents efficient immune responses to MAAs remains unknown. The autoimmune regulator (AIRE) controls the expression of tissue-specific self-antigens in thymic epithelial cells (TECs). The level of antigens expressed in the TECs determines the fate of auto-reactive thymocytes. Deficiency in AIRE leads in both humans (APECED patients) and mice to enlarged autoreactive immune repertoires. Here we show increased IgG levels to melanoma cells in APECED patients correlating with autoimmune skin features. Similarly, the enlarged T cell repertoire in AIRE−/− mice enables them to mount anti-MAA and anti-melanoma responses as shown by increased anti-melanoma antibodies, and enhanced CD4+ and MAA-specific CD8+ T cell responses after melanoma challenge. We show that thymic expression of gp100 is under the control of AIRE, leading to increased gp100-specific CD8+ T cell frequencies in AIRE−/− mice. TRP-2 (tyrosinase-related protein), on the other hand, is absent from TECs and consequently TRP-2 specific CD8+ T cells were found in both AIRE−/− and AIRE+/+ mice. This study emphasizes the importance of investigating thymic expression of self-antigens prior to their inclusion in vaccination and immunotherapy strategies

Much Ado About the TPP’s Effect on Pharmaceuticals

Ocular antigens are sequestered behind the blood-retina barrier and the ocular environment protects ocular tissues from autoimmune attack. The signals required to activate autoreactive T cells and allow them to cause disease in the eye remain in part unclear. In particular, the consequences of peripheral presentation of ocular antigens are not fully understood. We examined peripheral expression and presentation of ocular neo-self-antigen in transgenic mice expressing hen egg lysozyme (HEL) under a retina-specific promoter. High levels of HEL were expressed in the eye compared to low expression throughout the lymphoid system. Adoptively transferred naïve HEL-specific CD4+ T cells proliferated in the eye draining lymph nodes, but did not induce uveitis. By contrast, systemic infection with a murine cytomegalovirus (MCMV) engineered to express HEL induced extensive proliferation of transferred naïve CD4+ T cells, and significant uveoretinitis. In this model, wild-type MCMV, lacking HEL, did not induce overt uveitis, suggesting that disease is mediated by antigen-specific peripherally activated CD4+ T cells that infiltrate the retina. Our results demonstrate that retinal antigen is presented to T cells in the periphery under physiological conditions. However, when the same antigen is presented during viral infection, antigen-specific T cells access the retina and autoimmune uveitis ensues

Central CD4+ T cell tolerance: deletion versus regulatory T cell differentiation

The diversion of MHC class II-restricted thymocytes into the regulatory T (Treg) cell lineage, similarly to clonal deletion, is driven by intrathymic encounter of agonist self-antigens. Somewhat paradoxically, it thus seems that the expression of an autoreactive T cell receptor is a shared characteristic of T cells that are subject to clonal deletion and those that are diverted into the Treg cell lineage. Here, we discuss how thymocyte-intrinsic and -extrinsic determinants may specify the choice between these two fundamentally different T cell fates

Rereading cyborg(?) women: The visual rhetoric of images of cyborg (and cyber) bodies on the World Wide Web

Haraway\u27s \u27A Manifesto for Cyborgs\u27 marked a turning point in theory analyzing the intersections of machine and body. In the manifesto, she defined a cyborg as \u27a cybernetic organism, a hybrid of machine and organism, a creature of social reality as well as a creature of fiction.\u27 Haraway argued for finding pleasure in the border zone between social and body reality - a zone where post-genderedness is a possibility, a zone free of the boundaries of public and private. Although a variety of theorists have utilized Haraway\u27s work in arguing for the allure of the cyborg or the pleasures of cyborg discourse, few theorists have approached the cyborg as physical reality. As Gonzalez notes, where visual representations of the cyborg do exist, rarely are traditional, gendered Western roles (and bodies) challenged. The machinic, while offering liberation from gender, usually serves merely to reinforce the gender dynamics currently at play. In this article, I discuss images of \u27cyborg\u27 men and women found on the World Wide Web and argue that most visual representations of cyborg bodies are actually representations of \u27cyber\u27 bodies, which reinforce contemporary notions of masculinity, femininity, heterosexuality, and power. I will also, however, discuss other images that represent the possibilities Haraway and other theorists envision cyborgs as providing. These departures from cyber bodies offer productive ruptures through which alternative constructions of cyborg bodies can be envisioned