Incidence of suicidality in people with depression over a 10-year period treated by a large UK mental health service provider

We describe the incidence of suicidality (2007–2017) in people with depression treated by secondary mental healthcare services at South London and Maudsley NHS Trust (n = 26 412). We estimated yearly incidence of ‘suicidal ideation’ and ‘high risk of suicide’ from structured and free-text fields of the Clinical Record Interactive Search system. The incidence of suicidal ideation increased from 0.6 (2007) to 1 cases (2017) per 1000 population. The incidence of high risk of suicide, based on risk forms, varied between 0.06 and 0.50 cases per 1000 adult population (2008–2017). Electronic health records provide the opportunity to examine suicidality on a large scale, but the impact of service-related changes in the use of structured risk assessment should be considered

Putative Treponema pallidum cytadhesins share a common functional domain

Three putative Treponema pallidum ligands (P1, P2, and P3) that bind host fibronectin were characterized by peptide mapping. Papain digestion of each protein yielded a comigrating peptide of approximately 12,000 molecular weight. An antibody to this protein fragment inhibited T. pallidum host cytadherence, indicating that this peptide may be the functional domain of these treponemal adhesins

Electrophysiology of Error Processing : Does the Error Positivity Have a Mirror Image Negativity?

Color poster with text, charts, and graphs.Electroencephalography (EEG) is a measure of brain electrical activity from the scalp with components, such as positive and negative deflections in the signal, indexing various mental processes. If the inversion reflects the negative end of a single dipole, one would expect stronger correlations between anterior and posterior sites for the time windows of the Pethan at other times (~125-325 ms). If the inversion is due to referencing, one would expect a more consistent correlation between anterior and posterior sites throughout the entire time window.Student Blugold Commitment Differential Tuition; University of Wisconsin--Eau Claire Office of Research and Sponsored Programs