Covid 19: Need of vaccine induced herd immunity in India

Introduction: Herd immunity is a traditional concept nothing but a form of indirect protection from contagious diseases. In a mass community, there is no need to be everyone immune. If a high proportion of members in the community are immune, spreading of the disease is reduced even to non-immunized patients. This study offers an overview of vaccine-induced herd immunity importance in this pandemic and how it will be achieved. Methodology: The data of basic reproduction number Ro values for COVID 19 of 10 weeks in India which were estimated by Ro package in R software are extracted from a research article (reference no.4) and taken the mean Ro value due to fluctuations as well as to avoid great errors by using MS Excel. Herd immunity is calculated by using a standard equation stated as R=(1-Pc )(1-P1)Ro   Results:  The mean basic reproduction number Ro for COVID 19 in India was calculated as 1.671 by using MS excel and the herd 3 determines that only 40.16% proportion of individuals need to immunized through a vaccine to achieve herd immunity towards COVID 19 in India. Conclusion: This study estimates mean base reproduction Ro as 1.671 and Herd Immunity Threshold (HIT) as 40.16% by using past data. This study concludes that vaccine-induced herd immunity helps us by playing a key role to eliminate novel coronavirus

Effect of integrated nutrient supply on yield and uptake of cardamom (Elettaria cardamomum L. Maton.)

Field experiments were conducted for seven years (2000 to 2007) to assess the effect of integrated nutrient supply with Azospirillum and the combination of Azospirillum, FYM and graded levels of nitrogen on yield and uptake of cardamom. Results revealed that application of FYM @ 5 or 10 kg/plant with or without Azospirillum did not influence the yield components as well as yield levels appreciably. Application of FYM @ 5kg/ plant + 75 % recommended N + Azospirillum yielded 163.53 kg/ha similar to that of FYM @ 5 kg / plant + 100 % recommended N (175.42 kg/ha) and FYM @ 5 kg / plant + 50 % recommended N + Azospirillum yielded 141.20 kg/ha similar to that of FYM @ 5 kg / plant + 75 % recommended N (146.34 kg/ha), thereby providing 25 % saving in inorganic nitrogen. Further, FYM @ 5 kg / plant + 100% recommended N + Azospirillum, responded with 186.48 kg/ha but found on par to FYM @ 5 kg/ plant + 100 % recommended N (175.42 kg/ha). Integrated nutrient management treatments recorded higher nitrogen in plants compared to pure organic treatments. Influence of Azospirillum is not that conspicuous on nitrogen uptake by plants

Effect of Barrages and Anthropogenic Activities on Ecological Integrity of the Ganga River: A Review on Current Issues and Restoration Efforts

The Ganga River, a lifeline for millions of people in the Indian subcontinent, is facing significant environmental challenges due to the construction of barrages and various anthropogenic activities along its course. This review paper examines the effects of barrages and human interventions on the ecological integrity of the Ganga and explores current issues surrounding its deteriorating ecosystem. Furthermore, it discusses the restoration efforts undertaken to mitigate the ecological impacts and restore the river\u27s health. The construction of dams and barrages can aggravate the situation in the context of the Ganga, which is already suffering from the discharge of industrial and agricultural wastes. The construction of various dams, barrages, and hydroelectric projects is affecting the water flow of the Ganga.  These affect the water flow, resulting in the accumulation of solid waste on the river bed.  Barrages not only affect the water flow but also restrict the migration of aquatic fauna. This affects the hydrological balance of the Ganga as well as the survival and existence of several fish species. This review provides a comprehensive analysis of the effects of barrages and anthropogenic activities on Ganga\u27s ecological integrity, sheds light on the current issues plaguing the river, and highlights the ongoing restoration efforts. By understanding the complex interplay between human activities and ecosystem dynamics, stakeholders can work towards safeguarding Ganga\u27s ecological health and ensuring its sustainable future

P58IPK, a Plant Ortholog of Double-Stranded RNA-Dependent Protein Kinase PKR Inhibitor, Functions in Viral Pathogenesis

AbstractP58IPK is a cellular inhibitor of the mammalian double-stranded RNA-activated protein kinase (PKR). Here we provide evidence for the existence of its homolog in plants and its role in viral infection at the organism level. Viral infection of P58IPK-silenced Nicotiana benthamiana and Arabidopsis knockouts leads to host death. This host cell death is associated with phosphorylation of the α subunit of eukaryotic translation initiation factor (eIF-2α). Loss of P58IPK leads to reduced virus titer, suggesting that wild-type P58IPK protein plays an important role in viral pathogenesis. Although our complementation results using mammalian P58IPK suggest conservation of the P58IPK pathway in plants and animals, its biological significance seems to be different in these two systems. In animals, P58IPK is recruited by the influenza virus to limit PKR-mediated innate antiviral response. In plants, P58IPK is required by viruses for virulence and therefore functions as a susceptibility factor

Kikuchi-Fujimoto disease presenting as pyrexia of unknown origin

Background: Kikuchi-Fujimoto disease, a benign self-limited lymphadenopathy is an uncommon cause of pyrexia of unknown origin (PUO). Methods: We retrospectively studied the case-records of 13 patients presenting with PUO who were diagnosed to have Kikuchi-Fujimoto disease on peripheral lymph node excision biopsy and report the salient clinical manifestations and histopathological findings in them. All of them received symptomatic treatment. Results: Their median age was 28 [interquartile range (IQR) 18.5-38.0] years. Women (11/13, 84.6%) were more frequently affected. All of them were human immunodeficiency virus (HIV) seronegative. Prior to presenting to us, two were being treated for lymph node tuberculosis with DOTS. Cervical lymph nodes were predominantly involved, the distribution being: right cervical (n=10, 76.9%); left cervical (n=4); and bilateral cervical (n=2). Axillary and generalized lymphadenopathy were rare being seen in 2 and 1 patient respectively. The median (IQR) erythrocyte sedimentation rate (n=11) was 53 (35-89) mm at the end of first hour. Salient histopathological features were paracortical patchy zones of eosinophilic fibrinoid necrosis with karyorrhectic debris, large numbers of histiocytes, including histiocytes with peripherally placed “crescentic” nuclei. Spontaneous regression of fever and lymphadenopathy was observed over a median (IQR) period of 8 (6.75-10.25) months in all of them. Conclusions: Kikuchi-Fujimoto disease is a rare but important cause of PUO presenting with peripheral lymphadenopathy. Women are most often affected and cervical lymph nodes are the most frequently involved site. Clinical suspicion and thoughtful collaboration between clinicians and pathologists are essential for accurate diagnosis, and to minimize unnecessary investigations and inappropriate aggressive treatment

Surgical management of pterygium in a rural hospital using bare sclera versus conjunctival autograft technique

Background: Pterygium is defined as a triangular fibrovascular subepithelial ingrowth of degenerative bulbar conjunctival tissue over limbus onto the cornea. Commonly seen among farmers, fishermen, stone cutters and welders. Both blue and ultraviolet light have been implicated in its causation. Histologically the true Pterygium shows elastotic degeneration of the subconjunctival connective tissue. Pterygium warrant treatment when they encroach the visual axis, induces significant astigmatism or become cosmetically bothersome. My present study was undertaken to evaluate the efficacy, safety and recurrence rates of conjunctival autograft and bare sclera techniques in treatment of progressive true pterygium in a rural hospital.Methods: The prospective study was done in the Department of Ophthalmology, Adichunchanagiri Institute of Medical Sciences, B.G Nagara, Mandya District, Karnataka, India. The study was conducted for a period of 18 months. About 70 patients who presented with progressive pterygium were included in the study.Results: In our study pterygium recurred in 10 cases (14.28%), among which pterygium recurred in 8 cases (22.85 %) using bare sclera technique and in 2 patients (5.71%) using conjunctival autograft technique, best corrected visual acuity remained stable in 37 cases (52.85 %), improved in 33 cases (47.14 %) and worsened in none (0%) of the cases.Conclusions: Conjunctival autografting is a safe and effective procedure in the management of pterygium. The recurrence rate following limbal conjunctival autografting is significantly lower than that following primary conjunctival closure by bare sclera technique

A study of mode of transmission, clinical presentations, WHO and immunological staging among HIV infected children

Background: The clinical manifestations of HIV infection vary widely among infants, children, and adolescent. So there is a need to study the mode of transmission, clinical presentations, WHO and immunological staging among HIV infected children.Methods: Observational analytic cross sectional study. The children who were HIV positive (confirmed by ELISA for HIV-1 and HIV-2), and attending the OPD of ART Centre and SN Children Hospital, Allahabad during period of one year. The study population consisted of 47 patients, belonging to both sexes and age of 18 months to 19 years. Detailed history was taken and full clinical examination done in all cases. CD4 count was estimated at the time of presentation.Results: Predominant mode of transmission in our study was vertical and it was present in 95% cases. Fever was the most common presenting complaint and was present in 28 (59.57%) cases. The most common clinical sign was pallor in our study, present in 37 cases (78.72%) followed by lymphadenopathy 34 (72.34%). On the basis of WHO clinical staging, most of the patients in our study were found in stage 2 .On the basis of immunological staging, 51% had no evidence of immunosuppression (stage1), 18 (38.3%) had mild to advanced immunosuppression (stage 2 and 3) and 5 (10.63%) patients were severely immunosuppressed (stage 4). Conclusion: In HIV infected children predominant mode of transmission is vertical. Fever and pallor are common clinical manifestations. Most of the patients are found in WHO clinical stage 2 and immunological stage 1.

Effect of sodic water irrigation on yield and cation composition of vetiver (Vetiveria zizanioides (L.) Nash.)

The effect of residual sodium carbonate in irrigation water on the yield and cation composition of vetiver (Vetiueria zizanioides) was studied in open bottom reinforced concrete cemented cylindrical barrels embedded in the field at Lucknow, India. While shoot and root yields of vetiver were not significantly affected with residual sodium carbonate in irrigation water, oil yield significantly decreased at the residual sodium carbonate concentration of 8 meP and above as compared to control (tube well water). The concentration of sodium was about 10 times higher in the root than in shoot tissues. The great ability of vetiver to limit sodium entry in shoot tissues and maintain sufficient potassiunl and calcium concentration at high residual sodium carbonate concentration indicate that it is a tblerant to sadie stress. &nbsp