Humpback and Fin Whaling in the Gulf of Maine from 1800 to 1918

The history of whaling in the Gulf of Maine was reviewed primarily to estimate removals of humpback whales, Megaptera novaeangliae, especially during the 19th century. In the decades from 1800 to 1860, whaling effort consisted of a few localized, small-scale, shore-based enterprises on the coast of Maine and Cape Cod, Mass. Provincetown and Nantucket schooners occasionally conducted short cruises for humpback whales in New England waters. With the development of bomb-lance technology at mid century, the ease of killing humpback whales and fin whales, Balaenoptera physalus, increased. As a result, by the 1870’s there was considerable local interest in hunting rorquals (baleen whales in the family Balaenopteridae, which include the humpback and fin whales) in the Gulf of Maine. A few schooners were specially outfitted to take rorquals in the late 1870’s and 1880’s although their combined annual take was probably no more than a few tens of whales. Also in about 1880, fishing steamers began to be used to hunt whales in the Gulf of Maine. This steamer fishery grew to include about five vessels regularly engaged in whaling by the mid 1880’s but dwindled to only one vessel by the end of the decade. Fin whales constituted at least half of the catch, which exceeded 100 animals in some years. In the late 1880’s and thereafter, few whales were taken by whaling vessels in the Gulf of Maine

Archaeogenetic evidence of ancient Nubian barley evolution from six to two-row indicates local adaptation

Background Archaeobotanical samples of barley (Hordeum vulgare L.) found at Qasr Ibrim display a two-row phenotype that is unique to the region of archaeological sites upriver of the first cataract of the Nile, characterised by the development of distinctive lateral bracts. The phenotype occurs throughout all strata at Qasr Ibrim, which range in age from 3000 to a few hundred years. Methodology and Findings We extracted ancient DNA from barley samples from the entire range of occupancy of the site, and studied the Vrs1 gene responsible for row number in extant barley. Surprisingly, we found a discord between the genotype and phenotype in all samples; all the barley had a genotype consistent with the six-row condition. These results indicate a six-row ancestry for the Qasr Ibrim barley, followed by a reassertion of the two-row condition. Modelling demonstrates that this sequence of evolutionary events requires a strong selection pressure. Conclusions The two-row phenotype at Qasr Ibrim is caused by a different mechanism to that in extant barley. The strength of selection required for this mechanism to prevail indicates that the barley became locally adapted in the region in response to a local selection pressure. The consistency of the genotype/phenotype discord over time supports a scenario of adoption of this barley type by successive cultures, rather than the importation of new barley varieties associated with individual cultures

Best practices for selection of excipients for paediatrics - Workshop reflection

The development of age appropriate formulations for the paediatric population has become one of the key areas of focus for the pharmaceutical industry - with a subsequent influence on excipient use. Selection of excipients with appropriate safety and tolerability is a major hurdle in paediatric formulation development. Various factors influence selection of excipients, including target age group, route of administration and dosage form. Evaluation of these factors and a clear rationale and justification is expected by the regulators when it comes to selecting excipients for paediatric formulation. Scientists are encouraged to apply the principle of benefit to risk balance to assess the suitability of excipients to the specific paediatric population for whom the formulation is intended. In order to understand how scientists approach the task of establishing the risk to benefit analysis, a workshop was organised by the European Paediatric Formulation Initiative (EuPFI) to reflect on the current scenario and the different practices employed by formulation scientists in the selection of excipients for paediatric formulations. Aspects assessed by regulators were also canvassed. Finally, the participants were asked to comment on how selecting excipients for use in paediatric formulations may differ from the considerations applied in selecting excipients for formulations for other age groups. Based on the workshop discussion, some recommendations and questions to consider emerged regarding the selection of excipients in paediatric drug development. These best practice recommendations provided a good starting point for a more systematic strategy for selecting excipients for paediatric formulation development

Acceptability of generic versus innovator oral medicines: not only a matter of taste

Optimum use of generic products would require equivalence, not only in terms of quality, safety, and efficacy in clinical studies, but also patient acceptability to not jeopardize treatment success because of nonadherence which would de facto limit the potential cost saving anticipated by their use. Although acceptability is a requirement for the authorization of pediatric innovator products, our survey of European Union (EU) regulatory authorities showed that few have a formal process for assessing patient acceptability of generic products during the registration processes. The current International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) focus on unifying guidance for the development and scrutiny of generics but should include acceptability alongside the other factors being considered for harmonization

Responsible participation and housing: restoring democratic theory to the scene

Tensions between individual liberty and collective social justice characterise many advanced liberal societies. These tensions are reflected in the challenges posed for representative democracy both by participatory democratic practices and by the current emphasis on (so-called) responsible participation. Based on the example of ‘community’ housing associations in Scotland, this paper explores these tensions. It is argued that the critique of responsibility may have been over-stated – that, in particular, ‘community’ housing associations offer the basis for relatively more inclusive and effective processes of decision-making than council housing, which relies on the traditional processes and institutions of representative local government for its legitimacy

Inter-sexual and inter-seasonal differences in the chemical signalling strategies of brown bears

The brown bear (Ursus arctos) is a species which, due to its solitary, dominance hierarchy social system and large home range, is thought to rely heavily on chemical signals as a means of communication. Through camera traps orientated towards bear ‘rub trees’ over a two-year period, we assessed the proportional contribution of scent marking in different seasons by different age sex classes, and gained insights into the role of chemical signalling in maintaining social structure. We found, during the breeding season (June-July), that both adult males (n=38 P1 year (n=11 P=0.003) scent marked trees significantly more often than expected, whereas lone adult females (n=7) and subadults (n=3) marked less than expected. Outside of the breeding season (August-October), adult males (n=70) marked in an expected proportion, females with cubs (all ages) marked significantly more than expected (n=71 P<0.001), and lone adult females (n=11) and subadults (n=15) marked less than expected. During both the breeding season (n=7 P=0.026) and the fall (n=11 P<0.001), adult females marked trees significantly less than their occurrence on bear trails would expect, as did subadults during the breeding season (n=3 P=0.026) but not during the fall (n=15). Adult males marked at significantly high frequencies both during and outside of the breeding season, potentially to communicate dominance between males. Supported by the low frequency of scent marking by subadults. We observed a total avoidance of bear trails containing active rub trees by females with cubs <1 year during the breeding season, a possible counterstrategy to sexually selected infanticide due to the strong male bias in scent marking during the breeding season. We hypothesize that scent marking in brown bears is taught by the mother, beginning with cubs <1 year outside of the breeding season at a relatively ‘safe’ time of year

Using Markov Chain Analysis to assess stereotyped scent marking behaviour in wild brown bears

Members of the order Carnivora employ a wide range of postures and stereotyped patterns to mark their scent onto objects, and therein communicate with conspecifics. Despite much anecdotal evidence on the marking behaviour of Ursids, empirical data examining marking patterns displayed by wild populations is lacking. Situated on the west coast of British Columbia (2009-2011), we used trail cameras stationed at marking trees to investigate scent marking and investigatory behaviour by wild brown bears Ursus arctos. Transitions between postures were assessed using Markov Chain Analysis. Results showed that scent marking patterns varied by age and sex; adult males exhibited a cyclic pattern of marking behaviour which included ‘core’ and ‘secondary’ postures, whereas adult females failed to exhibit any subset postures. The behaviour of subadults (sexes combined) was a variation and simplification of the patterns displayed by adult males and females. The wider variety of marking postures selected by adult males may convey a more complex signal, relating to the function of scent marking in the species. Females with young were classified separately to assess potential similarities/differences in the behaviour of all members of the family group. Using a simplified ethogram, we found the behaviour of cubs to be dependent on their age and the behaviour of their mother. Younger cubs were more likely to conduct the same behaviour as their mother, whereas older cubs exhibited behaviours independently. This study presents the first detailed description of the development of scent marking behaviour by cubs in the Ursidae

Assessing the scent marking behaviour of wild brown bears: an exploration of time and energy investment, motor patterns and age-related development

Members of the order Carnivora employ a wide range of postures and stereotyped patterns to mark their scent onto objects and thereby communicate with conspecifics. Despite much anecdotal evidence on the marking behaviour of ursids, empirical evidence of scent marking motor patterns displayed by wild populations is lacking. Analysing the time bears spend at marking trees and the behaviours involved, could provide further insight into the function of marking and highlight time and energy investment. Over a three year period, camera traps stationed at marking trees were used to investigate scent marking and investigatory behaviour by wild brown bears Ursus arctos in coastal British Columbia. This work follows on from data presented at the 18th, 19th & 20th IBA conferences