270 research outputs found
Laue Lens Development for Hard X-rays (>60 keV)
Results of reflectivity measurements of mosaic crystal samples of Cu (111)
are reported. These tests were performed in the context of a feasibility study
of a hard X-ray focusing telescope for space astronomy with energy passband
from 60 to 600 keV. The technique envisaged is that of using mosaic crystals in
transmission configuration that diffract X-rays for Bragg diffraction (Laue
lens). The Laue lens assumed has a spherical shape with focal length . It is
made of flat mosaic crystal tiles suitably positioned in the lens. The samples
were grown and worked for this project at the Institute Laue-Langevin (ILL) in
Grenoble (France), while the reflectivity tests were performed at the X-ray
facility of the Physics Department of the University of Ferrara.Comment: 6 pages, 12 figures, accepted for publication in IEEE Transactions on
Nuclear Scienc
High-resolution quantitative MRI of multiple sclerosis spinal cord lesions
Purpose: Validation of quantitative MR measuresfor myelin imaging in the postmortem multiple sclerosis spinal cord.
Methods: Four fixed spinal cord samples were imaged first with a 3T clinical MR
scannerto identify areas of interest forscanning, and then with a 7T small bore scanner using a multicomponent-driven equilibrium single-pulse observation of T1 and
T2 protocol to produce apparent proton density, T1, T2, myelin water, intracellular
water, and free-water fraction maps. After imaging, the cords were sectioned and
stained with histological markers (hematoxylin and eosin, myelin basic protein, and
neurofilament protein), which were quantitatively compared with the MR maps.
Results: Excellent correspondence was found between high-resolution MR parameter maps and histology, particularly for apparent proton density MRI and
myelin basic protein staining.
Conclusion: High-resolution quantitative MRI of the spinal cord provides biologically meaningful measures, and could be beneficial to diagnose and track
multiple sclerosis lesions in the spinal cord
High-resolution quantitative MRI of multiple sclerosis spinal cord lesions
PURPOSE: Validation of quantitative MR measures for myelin imaging in the postmortem multiple sclerosis spinal cord. METHODS: Four fixed spinal cord samples were imaged first with a 3T clinical MR scanner to identify areas of interest for scanning, and then with a 7T small bore scanner using a multicomponentâdriven equilibrium singleâpulse observation of T(1) and T(2) protocol to produce apparent proton density, T(1), T(2), myelin water, intracellular water, and freeâwater fraction maps. After imaging, the cords were sectioned and stained with histological markers (hematoxylin and eosin, myelin basic protein, and neurofilament protein), which were quantitatively compared with the MR maps. RESULTS: Excellent correspondence was found between highâresolution MR parameter maps and histology, particularly for apparent proton density MRI and myelin basic protein staining. CONCLUSION: Highâresolution quantitative MRI of the spinal cord provides biologically meaningful measures, and could be beneficial to diagnose and track multiple sclerosis lesions in the spinal cord
Exploring the Hard X-/soft gamma-ray Continuum Spectra with Laue Lenses
The history of X-ray astronomy has shown that any advancement in our
knowledge of the X-ray sky is strictly related to an increase in instrument
sensitivity. At energies above 60 keV, there are interesting prospects for
greatly improving the limiting sensitivity of the current generation of direct
viewing telescopes (with or without coded masks), offered by the use of Laue
lenses. We will discuss below the development status of a Hard X-Ray focusing
Telescope (HAXTEL) based on Laue lenses with a broad bandpass (from 60 to 600
keV) for the study of the X-ray continuum of celestial sources. We show two
examplesof multi-lens configurations with expected sensitivity orders of
magnitude better ( photons cm s keV
at 200 keV) than that achieved so far. With this unprecedented sensitivity,
very exciting astrophysical prospects are opened.Comment: 4 pages, 10 figures, to be published in the Proc. of the 39th ESLAB
Symosium, 19-21 April 200
Rapid, energy-efficient synthesis of the layered carbide, Al<sub>4</sub>C<sub>3</sub>
The phase-pure binary aluminium carbide, Al4C3 can be synthesised in vacuo from the elements in 30 minutes via microwave heating in a multimode cavity reactor. The success of the reaction is dependent on the use of finely divided aluminium and graphite starting materials, both of which couple effectively to the microwave field. The yellow-brown powder product was characterised by powder X-ray diffraction, scanning electron microscopy/energy dispersive X-ray spectroscopy thermogravimetric-differential thermal analysis and Raman spectroscopy. Powders were composed of hexagonal single crystallites tens of microns in diameter (rhombohedral space group R[3 with combining macron]m; Z = 3; a = 3.33813(5) Ă
, c = 25.0021(4) Ă
) and were stable to 1000 °C in air, argon and nitrogen. Equivalent microwave reactions of the elements in air led to the formation of the oxycarbide phases Al2OC and Al4O4C
A Cylindrical GEM Inner Tracker for the BESIII experiment at IHEP
The Beijing Electron Spectrometer III (BESIII) is a multipurpose detector
that collects data provided by the collision in the Beijing Electron Positron
Collider II (BEPCII), hosted at the Institute of High Energy Physics of
Beijing. Since the beginning of its operation, BESIII has collected the world
largest sample of J/{\psi} and {\psi}(2s). Due to the increase of the
luminosity up to its nominal value of 10^33 cm-2 s-1 and aging effect, the MDC
decreases its efficiency in the first layers up to 35% with respect to the
value in 2014. Since BESIII has to take data up to 2022 with the chance to
continue up to 2027, the Italian collaboration proposed to replace the inner
part of the MDC with three independent layers of Cylindrical triple-GEM (CGEM).
The CGEM-IT project will deploy several new features and innovation with
respect the other current GEM based detector: the {\mu}TPC and analog readout,
with time and charge measurements will allow to reach the 130 {\mu}m spatial
resolution in 1 T magnetic field requested by the BESIII collaboration. In this
proceeding, an update of the status of the project will be presented, with a
particular focus on the results with planar and cylindrical prototypes with
test beams data. These results are beyond the state of the art for GEM
technology in magnetic field
Is multiple sclerosis a length-dependent central axonopathy? The case for therapeutic lag and the asynchronous progressive MS hypotheses
Trials of anti-inflammatory therapies in non-relapsing progressive multiple sclerosis (MS) have been stubbornly negative except recently for an anti-CD20 therapy in primary progressive MS and a S1P modulator siponimod in secondary progressive MS. We argue that this might be because trials have been too short and have focused on assessing neuronal pathways, with insufficient reserve capacity, as the core component of the primary outcome. Delayed neuroaxonal degeneration primed by prior inflammation is not expected to respond to disease-modifying therapies targeting MS-specific mechanisms. However, anti-inflammatory therapies may modify these damaged pathways, but with a therapeutic lag that may take years to manifest. Based on these observations we propose that clinically apparent neurodegenerative components of progressive MS may occur in a length-dependent manner and asynchronously. If this hypothesis is confirmed it may have major implications for the future design of progressive MS trials
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