Population genetics of abnormal haemoglobins in Burkina Faso, West Africa

Les fréquences géniques des hémoglobines A (HbA), HbS et HbC, ont été étudiées au Burkina-Faso (BF) ainsi que dans une région avoisinante du Niger : Ayorou. La fréquence d'HbS est plus élevée dans le Sahel (Nord du BF et Ayorou) que dans la zone de savane. L'inverse est trouvé pour HbC. Les résultats essentiels de ce travail sont : (a) la confirmation d'un pic de la fréquence génique de HbC dans le centre du BF (plateau Mossi); (b) une corrélation négative entre les fréquences de HbS et HbC. Cavalli-Sforza et Bodmer ont observé que cette corrélation atteint une intensité significativement différente de celle qui est attendue, par suite de la relation allélique entre HbS et HbC; (c) la comparaison de ces résultats avec les données rassemblées par Livingstone montre une modification de la valeur sélective des différents génotypes au cours des dernières années. Les individus AS ont une valeur sélective plus basse et les AA et SS en ont une plus haute. Nos données sont favorables à l'hypothèse du relâchement partiel de la sélection dans cette région. (Résumé d'auteur

Competing biosecurity and risk rationalities in the Chittagong poultry commodity chain, Bangladesh

This paper anthropologically explores how key actors in the Chittagong live bird trading network perceive biosecurity and risk in relation to avian influenza between production sites, market maker scenes and outlets. They pay attention to the past and the present, rather than the future, downplaying the need for strict risk management, as outbreaks have not been reported frequently for a number of years. This is analysed as ‘temporalities of risk perception regarding biosecurity’, through Black Swan theory, the idea that unexpected events with major effects are often inappropriately rationalized (Taleb in The Black Swan. The impact of the highly improbable, Random House, New York, 2007). This incorporates a sociocultural perspective on risk, emphasizing the contexts in which risk is understood, lived, embodied and experienced. Their risk calculation is explained in terms of social consent, practical intelligibility and convergence of constraints and motivation. The pragmatic and practical orientation towards risk stands in contrast to how risk is calculated in the avian influenza preparedness paradigm. It is argued that disease risk on the ground has become a normalized part of everyday business, as implied in Black Swan theory. Risk which is calculated retrospectively is unlikely to encourage investment in biosecurity and, thereby, points to the danger of unpredictable outlier events

Planck's scale dissipative effects in atom interferometry

Atom interferometers can be used to study phenomena leading to irreversibility and dissipation, induced by the dynamics of fundamental objects (strings and branes) at a large mass scale. Using an effective, but physically consistent description in terms of a master equation of Lindblad form, the modifications of the interferometric pattern induced by the new phenomena are analyzed in detail. We find that present experimental devices can in principle provide stringent bounds on the new effects.Comment: 12 pages, plain-Te

Jail fever (epidemic typhus) outbreak in Burundi.

We recently investigated a suspected outbreak of epidemic typhus in a jail in Burundi. We tested sera of nine patients by microimmunofluorescence for antibodies to Rickettsia prowazekii and Rickettsia typhi. We also amplified and sequenced from lice gene portions specific for two R. prowazekii proteins: the gene encoding for citrate synthase and the gene encoding for the rickettsial outer membrane protein. All patients exhibited antibodies specific for R. prowazekii. Specific gene sequences were amplified in two lice from one patient. The patients had typical clinical manifestations, and two died. Molecular techniques provided a convenient and reliable means of examining lice and confirming this outbreak. The jail-associated outbreak predates an extensive ongoing outbreak of louse-borne typhus in central eastern Africa after civil war and in refugee camps in Rwanda, Burundi (1), and Zaire