Influence of total sugar intake on metabolic blood markers at 8 years of age in the Childhood Obesity Project

PURPOSE We aimed to characterize the association of dietary sugar intake with blood lipids and glucose-related markers in childhood. METHODS Data from the multicentric European Childhood Obesity Project Trial were used. Three-day weighed dietary records were obtained at 8~years of age along with serum concentrations of triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, and insulin. Total sugar intake comprised all mono- and disaccharides; different sugar sources were defined. Linear regression models were applied to investigate the cross-sectional association of total sugar intake with blood lipids and glucose-related markers with adjustment for total energy intake using the residual method. RESULTS Data were available for 325 children. Children consumed on average 332~kcal (SD 110) and 21% (SD 6) of energy from total sugar. In an energy-adjusted model, an increase of 100~kcal from total sugar per day was significantly associated with a z score HDL-C decrease (-~0.14; 95% CI -~0.01, -~0.27; p value = 0.031). Concerning different food groups of total sugar intake, 100~kcal total sugar from sweetened beverages was negatively associated with z score HDL-C (-~1.67; 95% CI -~0.42, -~2.91; p value = 0.009), while total sugar from milk products was positively related to z score HDL-C (1.38, 95% CI 0.03, 2.72; p value = 0.045). None of the other blood lipids or glucose-related markers showed a significant relationship with total sugar intake. CONCLUSION Increasing dietary total sugar intake in children, especially from sweetened beverages, was associated with unfavorable effects on HDL-C, which might increase the long-term risk for dyslipidemia and cardiovascular disease. CLINICAL TRIAL REGISTRY ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: https://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1

Fault attack on the DVB Common Scrambling Algorithm

Abstract. The Common Scrambling Algorithm (CSA) is used to encrypt streams of video data in the Digital Video Broadcasting (DVB) system. The algorithm uses a combination of a stream and a block cipher, apparently for a larger security margin. However these two algorithms share a common key. In this paper we present a fault attack on the block cipher which can be launched without regarding the stream cipher part. This attack allows us to reconstruct the common key and thus breaks the complete Algorithm

Associations of sugar intake with anthropometrics in children from ages 2 until 8 years in the EU Childhood Obesity Project

Purpose: We determined the association of total sugar intake with body weight and fat mass in children on an energy-equivalent basis and potential changes in the association from 2 to 8 years of age. Methods: Data were available from the Childhood Obesity Project Trial initiated in 2002. Sugar intake was measured by 3-day weighed food protocols at 2, 3, 4, 5, 6, and 8 years of age. Body mass index (BMI) and fat mass index (FMI) were available at the same time points. To investigate the association of sugar intake with anthropometrics over time, linear mixed models were applied. Odds ratios for having a high BMI or FMI (above one standard deviation) were estimated by logistic random-effects models. To control for total energy intake, the residual method was chosen and models were additionally adjusted for total energy intake. Results: Data were available for 809 children with in total 2846 observations. In an isocaloric model, an increase of 100 kcal from sugar per day was significantly associated with lower zBMI ( 12 0.033; 95% CI 120.061, 12 0.005) and zFMI ( 12 0.050; 95% CI 12 0.089, 12 0.011). In addition, a 100 kcal higher sugar intake was related to lower odds of having a high zBMI (OR 0.743; 95% CI 0.611, 0.903). Conclusion: This study provides no indication that increased total sugar intake positively affects BMI on an energy-equivalent basis. Whether the negative association of sugar is due to physiological effects or points more to macronutrient preferences or a reporting bias (lower sugar intake) in children with higher BMI can be debated. Clinical trial registry: ClinicalTrials.gov Identifier: NCT00338689; Registered: June 19, 2006. URL: http://clinicaltrials.gov/ct2/show/NCT00338689?term=NCT00338689&rank=1