Usage of JSF framework and EJB technology in the creation of corporate applications

In the following article we describe the architecture of an online store project, which is an application utilising Java Enterprise Edition. Our project is based on a customer expectations model. The choice of technology has been due to its easy expandability by additional modules as well as its functionality which does not require reorganising the existing code

Evaluation of Anti-cancer Activity of Stilbene and Methoxydibenzo[b,f] oxepin Derivatives

Background: Stilbenes, 1,2-diphenylethen derivatives, including resveratrol and combretastatins, show anticancer features especially against tumor angiogenesis. Fosbretabulin, CA-4, in combination with carboplatin, is in the last stages of clinical tests as an inhibitor of thyroid cancer. The mode of action of these compounds involves suppression of angiogenesis through interfering with tubulin (de)polymerization. Objective: We have previously synthesized five E-2-hydroxystilbenes and seven dibenzo[b,f]oxepins in Z configuration, with methyl or nitro groups at varied positions. The aim of the present work was to evaluate the anticancer activity and molecular mechanism(s) of action of these compounds. Results: Two healthy, EUFA30 and HEK293, and two cancerous, HeLa and U87, cell lines were treated with four newly synthetized stilbenes and seven oxepins. Two of these compounds, JJR5 and JJR6, showed the strongest cytotoxic effect against cancerous cells tested and these two were selected for further investigations. They induced apoptosis with sub-G1 or S cell cycle arrest and PARP cleavage, with no visible activation of caspases 3 and 7. Proteomic differential analysis of stilbene-treated cells led to the identification of proteins involved almost exclusively in cell cycle management, apoptosis, DNA repair, and stress response, e. g. oxidative stress. Conclusions: Among newly synthesized stilbene derivatives we selected two as potent anticancer compounds triggering late apoptosis/necrosis in cancerous cells through sub-G1 phase cell cycle arrest. They changed cyclin expression, induced DNA repair mechanisms, enzymes involved in apoptosis, and oxidative stress response. Compounds JJR5 and JJR6 can be a base for structure modification(s) to obtain even more active derivatives

High risk of invasive fungal disease in children undergoing hematopoietic cell transplantation or complex anticancer therapy: the adverse role of post-transplant CMV replication

Introduction: We analyzed the epidemiology and outcomes of treatment of invasive fungal disease (IFD) in children during anticancer therapy (PHO, pediatric hematology and oncology) or after hematopoietic cell transplantation (HCT) over a period of eight consecutive years in a single-center study. Material and methods: Overall, a total of 254 HCTs were performed, and 415 children were newly diagnosed for malignancy. Incidence, epidemiology and outcome of IFD were analyzed. Results: The cumulative incidence of any IFD was 32.6% in allo-HCT, 22.2% in PHO, and 6.0% in auto-HCT patients. The incidence of proven +probable IFD was 12.6%, 10.4%, and 6.0%, respectively. As many as 77.0% HCT and 67.4% PHO of fungal episodes occurred in acute leukemia patients: the highest incidence of any IFD was observed for acute lymphoblastic leukemia (29.3% in HCT; 40.5% in PHO) and for acute myeloblastic leukemia (51.1% in HCT; 65.0% in PHO) patients. There were no significant differences in the incidence of fungal infections in both allo-HCT and PHO patients between the 2-year periods. Factors contributing to an increased risk of IFD in allo-HCT patients were: CMV replication, and acute and chronic graft-versus-host disease (GvHD). Survival from IFD was 91.9% in PHO, and 78.1% in HCT patients. Fungal pneumonia in HCT patients resolved in 62.9%, while in PHO patients it resolved in 93.5%. Conclusions: The risk of IFD in allo-HCT patients is much higher than in auto-HSCT and PHO patients. The outcome of IFD is better in PHO and auto-HCT than in allo-HCT settings

Myofascial and balance tests after anterior cruciate ligament reconstruction in adolescent patients

Study aim: The functional assessment of patients after anterior cruciate ligament reconstruction (ACLR) is one of the key points in deciding whether one can safely return to physical activity. The aim of this study is to investigate the usefulness of the NEURAC® tests and single leg balance test (SLBT) in the functional evaluation of adolescent patients after ACLR to detect differences between the operated and non-operated extremity

Process of photogrammetry with use of custom made workstation as a method of digital recording of anatomical specimens for scientific and research purposes

This work aims to use photogrammetry to prepare the base of anatomical specimens for teaching and research purposes. Photogrammetry consists in preparing a 3D model of an object with the use of a specially designed program, e.g. Meshroom, based on the photos of an object taken from various angles. To enhance the process of taking photos for 3D models, a workstation has been designed and developed. It consists of the frame with a slowly rotating specimen (360° per minute) attached. The object is photographed from each side and at various angles. In the next stage of processing the model, the photos are sent to a graphic designer who creates the first model and then the final one. The prepared 3D models are intended to be used for academic teaching and specialist training. They can also be used for further research, measurements or to plan surgical procedures. At the moment, the base prepared with this method contains the entire human skeleton, several joints, and parenchymal organs. It has been systematically expanded as the goal is to include all human organs grouped into systems.This article does not aim to describe the photogrammetry method itself as it has been already presented in details in other publications[1]. This research focuses on presenting one of the several available methods of obtaining images of objects prone to change their shapes and thus difficult to be captured in the photo taken from several angles. The method presented in this article uses a custom made workstation to ensure a stable environment and conditions for taking photos of rotating objects, which are described later in this article