Erectile dysfunction, physical activity and metabolic syndrome: differences in markers of atherosclerosis

<p>Abstract</p> <p>Background</p> <p>Erectile dysfunction (ED), impaired arterial elasticity, elevated resting heart rate as well as increased levels of oxidized LDL and fibrinogen associate with future cardiovascular events. Physical activity is crucial in the prevention of cardiovascular diseases (CVD), while metabolic syndrome (MetS) comprises an increased risk for CVD events. The aim of this study was to assess whether markers of subclinical atherosclerosis are associated with the presence of ED and MetS, and whether physical activity is protective of ED.</p> <p>Methods</p> <p>57 MetS (51.3 ± 8.0 years) and 48 physically active (PhA) (51.1 ± 8.1 years) subjects participated in the study. ED was assessed by the International Index of Erectile Function (IIEF) questionnaire, arterial elasticity by a radial artery tonometer (HDI/PulseWave™ CR-2000) and circulating oxLDL by a capture ELISA immunoassay. Fibrinogen and lipids were assessed by validated methods. The calculation of mean daily energy expenditure of physical exercise was based on a structured questionnaire.</p> <p>Results</p> <p>ED was more often present among MetS compared to PhA subjects, 63.2% and 27.1%, respectively (p < 0.001). Regular physical exercise at the level of > 400 kcal/day was protective of ED (OR 0.12, 95% CI 0.017-0.778, p = 0.027), whereas increased fibrinogen (OR 4.67, 95% CI 1.171-18.627, p = 0.029) and elevated resting heart rate (OR 1.07, 95% CI 1.003-1.138, p = 0.04) were independently associated with the presence of ED. In addition, large arterial elasticity (ml/mmHgx10) was lower among MetS compared to PhA subjects (16.6 ± 4.0 <it>vs</it>. 19.6 ± 4.2, p < 0.001), as well as among ED compared to non-ED subjects (16.7 ± 4.6 <it>vs</it>. 19.0 ± 3.9, p = 0.008). Fibrinogen and resting heart rate were highest and large arterial elasticity lowest among subjects with both MetS and ED.</p> <p>Conclusions</p> <p>Markers of subclinical atherosclerosis associated with the presence of ED and were most evident among subjects with both MetS and ED. Thus, especially MetS patients presenting with ED should be considered at high risk for CVD events. Physical activity, on its part, seems to be protective of ED.</p> <p>Trial registration</p> <p>ClinicalTrials.gov <a href="http://www.clinicaltrials.gov/ct2/show/NCT01119404">NCT01119404</a></p

Synanaire&#297;sthai e Aufheben: alguns aspectos das dialéticas platônica e hegeliana

Explico, primeiramente, lançando mão dos textos de Platão, Aristóteles e Sexto Empírico, o sentido de synanaire)sthai no contexto da identificação das dimensões do ser e das faculdades da alma. Depois, passo, então, ao comentário hegeliano da dialética platônica. Nesta parte do texto, discuto os significados de synanaire)sthai e Aufheben e algumas diferenças entre as dialéticas platônica e hegeliana.<br>Firstly, by using Plato's, Aristotle's and Sextus Empiricus' texts, I explain the meaning of synanaire)sthai in the context of the dimensions of being and soul's affections. After that, I proceed then to Hegel's commentary on Plato's dialectic. In this part of the text, I discuss the meanings of synanaire)sthai and Aufheben as well as some differences of Hegel's and Plato's dialectics

Autonomous self and inter-processual self: two ways of explaining how people “see” and live relationships and the resulting dialogue between science and faith

The relationship between science and faith is not a given, nor is it objectively defined, but rather depends on personal ways of approaching this relationship. Accordingly, it can be lived as a conflict, i.e. as agency striving to master independent and separate domains or as a process of dialogue or an integral relationship. In this chapter, we suggest that adopting one stance or the other depends on factors that go beyond the rational assessment that a person makes of science or faith. To explain the perspective that people adopt, cross-disciplinary theoretical insights relevant to human beings and their development are decisive. Based on previous research consolidating several theoretical proposals across a diverse disciplinary orientation (mainly philosophy, psychology and neuroscience), we suggest that there are two contrasting paradigms for conceiving of the self and human development, namely, the autonomous self (AS) and the inter-processual self (IPS) (Akrivou K, Orón JV: Challenges of capitalism for virtue and the common good: Inter-disciplinary perspectives. Edward Elgar, Cheltenham, 2016). We purport here that, depending on which of these two corresponding backgrounds characterises the person, people will ‘see’ and live the relationship—dialogue between science and faith—differently