The Grizzly, January 27, 2005

Ashley Lynn McCaleb: Scholar, Daughter, Friend • I Want to be Made Into an RA • Students Take Action at the Presidential Inauguration • New Member Education Returns • Fatal Blow • Myrin Undergoes Major Changes • Tsunami Relief Efforts Taking Shape at Ursinus • Ursinus Students Make Requests for The Facebook • Opinions: Is Mother Nature Trying to Tell us Something?; Bush\u27s New Cabinet Appointments may not be the Wisest • Bears Battling Without Stanton • Dedication and Attitude Forms a True Competitorhttps://digitalcommons.ursinus.edu/grizzlynews/1575/thumbnail.jp

The Grizzly, November 8, 2012

Hurricane Hits UC, Campus Evacuated • Sandy: Climate Change? • Alumni Give Back to Ursinus • Hillel Fosters an Open Community • Christmas Mall • New Faculty Members in Residence 2012 • Photography Club Returns to Campus • Henna Event in Celebration of TWLOHA Day • Opinion: Sandy Victims Deserve Respect, Support; Gender Roles Changing in America • Spotlight: Chris Rountree, Football • Men\u27s Swimming Looks to Have Big 2012 Season • Team Preview: Women\u27s Swimminghttps://digitalcommons.ursinus.edu/grizzlynews/1869/thumbnail.jp

The Grizzly, November 15, 2012

Website Sparks Campus Controversy • New Sculptures Share Connections with CIE Text • Underclassmen to Register on New Electronic System • Sandy Victims Still Need Aid • UCDC Fall Preview • Dr. Romano\u27s Book • Radio City Christmas Spectacular • Commuters at UC • Opinion: Disputed Website Shows Ursinus\u27 True Colors; It\u27s Becoming More Popular to Follow Celebrities\u27 Lives • Rough Time to be a Philadelphia Fan • Women\u27s Basketball Looks to Youth for Victories • Men\u27s Basketball Looks to Reboundhttps://digitalcommons.ursinus.edu/grizzlynews/1870/thumbnail.jp

The Grizzly, October 26, 2006

Editorial: Putting the Pieces Back Together • Possible Scam Raises Concerns • Town Hall Meeting Brings Forth Campus Issues • Food Drive a Success • Fall is in the Air • Story Behind the Statue: Praha • Get to Know the Nominees • Opinions: Long Live Noise; Swept Under the Rug; Truth About Study Abroad • Women\u27s Volleyball Swept by Gettysburg • Bullets Offense Too Much for Bears • Bears Make Run for Playoffshttps://digitalcommons.ursinus.edu/grizzlynews/1722/thumbnail.jp

The Grizzly, October 25, 2012

UCARE Directs Week of Local Service • UC Gears up for Homecoming • Report on Grads\u27 Successes • Grizzly Gala: Food, Drinks and Music • Teach for America • Homecoming Nominations • Headphone Disco • Opinion: Ursinus Sports Teams Need More Support; Varsity Teams and Athletes Overvalued at Ursinus • Ursinus Finalizes New Athletics Logo • Senior Spotlight: Kristin Hanratty, UC Volleyball • Homecoming Special for Class of \u2713https://digitalcommons.ursinus.edu/grizzlynews/1867/thumbnail.jp

The Grizzly, September 13, 2012

UC Remembers Lindsay Budnick • Greek Recruitment Changes • UC Fringe Returns • Film Fest to Celebrate Cultures • Bear Bucks Defined • CIE Fellows Aid CIE Students • CAB Welcomes New Executive Board and Events • Tree Planting Efforts Along the Perkiomen Creek • Opinion: New Allowances Limit SPINT Events; DNC Speakers Successfully Promote Obama • Season Preview: Women\u27s Soccer • Coach Profile: Kelly Wakeman, Women\u27s Soccer • Men\u27s Soccer Goes Young for Successhttps://digitalcommons.ursinus.edu/grizzlynews/1862/thumbnail.jp

The Relationship Between Coping, Burnout, and Resilience for Allied Health Professions Graduate Students

Purpose: The purpose of this study was to determine the relationship between coping strategies, resilience, and mental health in graduate allied health professions students to prevent burnout. Method: The REDCap electronic survey platform was used to collect data from the Patient Health Questionnaire (PHQ-9), Brief Resilience Scale (BRS), Maslach Burnout Inventory (MBI) General Survey for Students, and Coping Orientation to Problems Experienced (Brief-COPE). A convenience sample of graduate students (n=40) in healthcare professions was recruited to participate at a select university in Florida. Demographic data included the students\u27 age, gender, allied health program, and year in program. Quantitative analysis for descriptive statistics and comparison of intrapersonal and interpersonal variables were conducted. Results: The findings of this study were inconclusive due to the inconsistent relationships between the measures. No significant relationship was noted between coping strategies, levels of resilience, burnout, and mental health impairments for allied health professions graduate students. . Conclusion: It is recommended that further research be conducted to explore how resilience and mental health mitigate burnout as well as how specific coping strategies influence burnout

Targeting the fatty acid binding proteins disrupts multiple myeloma cell cycle progression and MYC signalin

Multiple myeloma is an incurable plasma cell malignancy with only a 53% 5-year survival rate. There is a critical need to find new multiple myeloma vulnerabilities and therapeutic avenues. Herein, we identified and explored a novel multiple myeloma target: the fatty acid binding protein (FABP) family. In our work, myeloma cells were treated with FABP inhibitors (BMS3094013 and SBFI-26) and examined in vivo and in vitro for cell cycle state, proliferation, apoptosis, mitochondrial membrane potential, cellular metabolism (oxygen consumption rates and fatty acid oxidation), and DNA methylation properties. Myeloma cell responses to BMS309403, SBFI-26, or both, were also assessed with RNA sequencing (RNA-Seq) and proteomic analysis, and confirmed with western blotting and qRT-PCR. Myeloma cell dependency on FABPs was assessed using the Cancer Dependency Map (DepMap). Finally, MM patient datasets (CoMMpass and GEO) were mined for expression correlations with clinical outcomes. We found that myeloma cells treated with FABPi or with knockout (generated via CRISPR/Cas9 editing) exhibited diminished proliferation, increased apoptosis, and metabolic changes in vitro. FABPi had mixed results in vivo, in two pre-clinical MM mouse models, suggesting optimization of in vivo delivery, dosing, or type of FABP inhibitors will be needed before clinical applicability. FABPi negatively impacted mitochondrial respiration and reduced expression of MYC and other key signaling pathways in MM cells in vitro. Clinical data demonstrated worse overall and progression-free survival in patients with high expression in tumor cells. Overall, this study establishes the FABP family as a potentially new target in multiple myeloma. In MM cells, FABPs have a multitude of actions and cellular roles that result in the support of myeloma progression. Further research into the FABP family in MM is warrented, especially into the effective translation of targeting these in vivo