Roles of stiffness and excluded volume in DNA denaturation

The nature and the universal properties of DNA thermal denaturation are investigated by Monte Carlo simulations. For suitable lattice models we determine the exponent c describing the decay of the probability distribution of denaturated loops of length l, $P \sim l^{-c}$. If excluded volume effects are fully taken into account, c= 2.10(4) is consistent with a first order transition. The stiffness of the double stranded chain has the effect of sharpening the transition, if it is continuous, but not of changing its order and the value of the exponent c, which is also robust with respect to inclusion of specific base-pair sequence heterogeneities.Comment: RevTeX 4 Pages and 4 PostScript figures included. Final version as publishe

Investigation of the structure and catalytic activity in olefin cyclopropanation of neutral and cationic dicopper complexes of 3,5-bis(pyridinylimino)benzoic acid.

Three neutral and one cationic copper(I) complexes with 3,5-bis(pyridinylimino)benzoic acid are synthesized and characterized in solution and in the solid state by a variety of spectroscopic techniques and X-ray crystallography. The compounds are tested for their catalytic activity in olefin cyclopropanation reactions by means of ethyl diazoacetate decomposition and prove to be moderately active with the ionic one being the most active and the most promising since for cyclohexene it reveals a considerable diastereoselectivity and a 90:10 exo:endo ratio of the final product

Texture profile and sensory acceptance of a symbiotic diet aerated mousse containing Lactobacillus acidophilus LA-5, inulin, and fructooligosaccharide

This work dealt with the texture profile and sensory acceptance of a symbiotic diet aerated mousse containing Lactobacillus acidophilus LA-5, inulin, and fructooligosaccharid

First order wetting of rough substrates and quantum unbinding

Replica and functional renormalization group methods show that, with short range substrate forces or in strong fluctuation regimes, wetting of a self-affine rough wall in 2D turns first-order as soon as the wall roughness exponent exceeds the anisotropy index of bulk interface fluctuations. Different thresholds apply with long range forces in mean field regimes. For bond-disordered bulk, fixed point stability suggests similar results, which ultimately rely on basic properties of quantum bound states with asymptotically power-law repulsive potentials.Comment: 11 pages, 1 figur

Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis.

Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy. However, its role in macrophages remains elusive. We report that pharmacologic inhibition of GS skews M2-polarized macrophages toward the M1-like phenotype, characterized by reduced intracellular glutamine and increased succinate with enhanced glucose flux through glycolysis, which could be partly related to HIF1α activation. As a result of these metabolic changes and HIF1α accumulation, GS-inhibited macrophages display an increased capacity to induce T cell recruitment, reduced T cell suppressive potential, and an impaired ability to foster endothelial cell branching or cancer cell motility. Genetic deletion of macrophagic GS in tumor-bearing mice promotes tumor vessel pruning, vascular normalization, accumulation of cytotoxic T cells, and metastasis inhibition. These data identify GS activity as mediator of the proangiogenic, immunosuppressive, and pro-metastatic function of M2-like macrophages and highlight the possibility of targeting this enzyme in the treatment of cancer metastasis

From waves to avalanches: two different mechanisms of sandpile dynamics

Time series resulting from wave decomposition show the existence of different correlation patterns for avalanche dynamics. For the d=2 Bak-Tang-Wiesenfeld model, long range correlations determine a modification of the wave size distribution under coarse graining in time, and multifractal scaling for avalanches. In the Manna model, the distribution of avalanches coincides with that of waves, which are uncorrelated and obey finite size scaling, a result expected also for the d=3 Bak et al. model.Comment: 5 pages, 4 figure

Peculiar scaling of self-avoiding walk contacts

The nearest neighbor contacts between the two halves of an N-site lattice self-avoiding walk offer an unusual example of scaling random geometry: for N going to infinity they are strictly finite in number but their radius of gyration Rc is power law distributed, ~ Rc^{-\tau}, where \tau>1 is a novel exponent characterizing universal behavior. A continuum of diverging lengths scales is associated to the Rc distribution. A possibly super-universal \tau=2 is also expected for the contacts of a self-avoiding or random walk with a confining wall.Comment: 4 pages, 5 Postscript figures, uses psfig.sty; some sentences clarifie

The development of a new blood substitute

Trattasi di un sommario pubblicato online nel sito dell'Agenzia di divulgazione scientifica Atlas of Science, AoS Nordic AB, Moscow, Russia, riguardante l'impiego di nuovi sostituti del sangu

Scaling in DNA unzipping models: denaturated loops and end-segments as branches of a block copolymer network

For a model of DNA denaturation, exponents describing the distributions of denaturated loops and unzipped end-segments are determined by exact enumeration and by Monte Carlo simulations in two and three dimensions. The loop distributions are consistent with first order thermal denaturation in both cases. Results for end-segments show a coexistence of two distinct power laws in the relative distributions, which is not foreseen by a recent approach in which DNA is treated as a homogeneous network of linear polymer segments. This unexpected feature, and the discrepancies with such an approach, are explained in terms of a refined scaling picture in which a precise distinction is made between network branches representing single stranded and effective double stranded segments.Comment: 8 pages, 8 figure