6,582 research outputs found
Implications of gauge-mediated supersymmetry breaking with vector-like quarks and a ~125 GeV Higgs boson
We investigate the implications of models that achieve a Standard Model-like
Higgs boson of mass near 125 GeV by introducing additional TeV-scale
supermultiplets in the vector-like 10+\bar{10} representation of SU(5), within
the context of gauge-mediated supersymmetry breaking. We study the resulting
mass spectrum of superpartners, comparing and contrasting to the usual
gauge-mediated and CMSSM scenarios, and discuss implications for LHC
supersymmetry searches. This approach implies that exotic vector-like fermions
t'_{1,2}, b',and \tau' should be within the reach of the LHC. We discuss the
masses, the couplings to electroweak bosons, and the decay branching ratios of
the exotic fermions, with and without various unification assumptions for the
mass and mixing parameters. We comment on LHC prospects for discovery of the
exotic fermion states, both for decays that are prompt and non-prompt on
detector-crossing time scales.Comment: 32 pages. v2: references added, figure caption 5.3 correcte
Preservative-free versus preserved latanoprost eye drops for reducing intraocular pressure: a non-inferiority phase III randomized, multi-center, single-blind, parallel-group controlled trial
Background: The aim of this study was to test the non-inferiority of preservative-free (PF) latanoprost 50 μg/mL multi-dose ophthalmic solution versus the marketed benzalkonium chloride (BAK)-preserved latanoprost 50 μg/mL ophthalmic solution in patients with open-angle glaucoma and patients with ocular hypertension.
Methods: This was a prospective, national, randomized, multi-center, observer-blind, parallel-group controlled clinical trial. Patients were randomized to receive either PF or BAK-preserved latanoprost once daily for 12 weeks. The primary endpoint was the change in intraocular pressure (IOP) at 8:00 AM in the affected eye between the end of the treatment (week 12) and the baseline (week 0). Secondary measurements were taken at weeks 2 and 6, with IOP being recorded at 8:00 AM, 12:00 PM, and 4:00 PM.
Results: A total of 158 patients were included in the per protocol (PP) population (77 in the PF latanoprost treatment arm and 81 patients in the BAK-preserved latanoprost treatment arm). PF latanoprost was non-inferior to BAK-preserved latanoprost in reducing IOP at 8:00 AM in the study eye from the baseline (week 0) to the end of the treatment (week 12). The point estimate of the between-treatment difference was 0.1 mmHg (95% confidence interval: -0.646, 0.847). Mean between-group differences in IOP reduction from the baseline to each of the secondary measurements were also similar between the two treatment arms. The two treatments were well tolerated and had comparable adverse event profiles.
Conclusions: PF latanoprost was non-inferior to BAK-preserved latanoprost in reducing IOP in patients with open-angle glaucoma or ocular hypertension. Both treatments were well tolerated
Non-inferiority evaluation of preservative-free latanoprost/timolol eye drops solution versus preserved latanoprost/timolol eye drops in patients with high intraocular pressure and open-angle glaucoma
Background: This study aimed to evaluate the non-inferiority and safety of a newly developed preservative-free (PF) multi-dose latanoprost/timolol ophthalmic solution, compared with the benzalkonium chloride (BAK)-preserved fixed combination, in patients with open-angle glaucoma and ocular hypertension.Methods: A Phase III randomized multi-center observer-blind parallel-group clinical trial was conducted. A total of 210 adult patients (aged over 18 years) were randomly treated with the PF- or the BAK-preserved latanoprost/timolol solution once daily in the affected eye(s) for 12 weeks. Follow-up visits were scheduled at weeks 2, 6, and 12; intraocular pressure (IOP) was recorded at 8:00 AM, 12:00 PM, and 4:00 PM. The primary efficacy endpoint to prove non-inferiority was the IOP change at 8:00 AM (± 1 hour) from the baseline to the end of treatment (week 12) in the studied eye. Safety parameters were also assessed.Results: In total, 196 patients completed the study. The pressure-lowering effect of the PF eye drops was comparable to that of the preserved formulation at all time points. Latanoprost/timolol PF formulation was non-inferior to the BAK-preserved solution as shown by the change in IOP from day 0 to week 12. The point estimate of the inter-treatment difference was 0.624 mmHg (95% CI: -0.094, 1.341). Both treatments were well-tolerated during the study, and they had similar adverse event profiles.Conclusions: PF-latanoprost/timolol combination was found to be non-inferior to the BAK-preserved formulation based on the efficacy at all times, with similar local tolerance
Search for the K(L) --> PI0 PI0 E+ E- Decay in the KTeV Experiment
The recent discovery of a large CP violating asymmetry in K(L) --> PI+ PI- E+
E- mode has prompted us to seach for the associated K(L) --> PI0 PI0 E+ E-
decay mode in the KTeV-E799 experiment at Fermilab. In 2.7E+11 K(L) decays, one
candidate event has been observed with an expected background of 0.3 event,
resulting in an upper limit for the K(L) --> PI0 PI0 E+ E- branching ratio of
6.6E-09 at the 90% confidence level.Comment: To be published in Phys. Rev. Let
Measurements of the rare decay K_{L} -> e^{+} e^{-} e^{+} e^{-}
We observe 441 K_{L} -> e^{+} e^{-} e^{+} e^{-} candidate events with a
background of 4.2 events and measure B(K_{L} -> e^{+} e^{-} e^{+} e^{-}) =
(3.72 \pm 0.18(stat) \pm 0.23(syst)) \times 10^{-8} in the KTeV/E799II
experiment at Fermilab. Using the distribution of the angle between the planes
of the e^{+} e^{-} pairs, we measure the CP parameters beta_{CP} = -0.23 \pm
0.09(stat) \pm 0.02(syst) and gamma_{CP} = -0.09 \pm 0.09(stat) \pm 0.02(syst).
We also present the first detailed study of the e^{+} e^{-} invariant mass
spectrum in this decay mode.Comment: 14 pages, 4 figure
Jet Substructure at the Tevatron and LHC: New results, new tools, new benchmarks
In this report we review recent theoretical progress and the latest
experimental results in jet substructure from the Tevatron and the LHC. We
review the status of and outlook for calculation and simulation tools for
studying jet substructure. Following up on the report of the Boost 2010
workshop, we present a new set of benchmark comparisons of substructure
techniques, focusing on the set of variables and grooming methods that are
collectively known as "top taggers". To facilitate further exploration, we have
attempted to collect, harmonise, and publish software implementations of these
techniques.Comment: 53 pages, 17 figures. L. Asquith, S. Rappoccio, C. K. Vermilion,
editors; v2: minor edits from journal revision
Measurement of the branching ratio of pi^0 -> e^+e^- using K_L -> 3 pi^0 decays in flight
The branching ratio of the rare decay pi^0 -> e^+e^- has been measured in
E799-II, a rare kaon decay experiment using the KTeV detector at Fermilab. The
pi^0's were produced in fully-reconstructed K_L -> 3 pi^0 decays in flight. We
observed 275 candidate pi^0 -> e^+e^- events, with an expected background of
21.4 +- 6.2 events which includes the contribution from Dalitz decays. We
measured BR(pi^0 -> e^+e^-, x>0.95) = (6.09 +- 0.40 +- 0.24) times 10^{-8},
where the first error is statistical and the second systematic. This result is
the first significant observation of the excess rate for this decay above the
unitarity lower bound.Comment: New version shortened to PRL length limit. 5 pages, 4 figures.
Published in Phys. Rev. Let
Light Gluino Search for Decays Containing pi+pi- or pi0 from a Neutral Hadron Beam at Fermilab
We report on two null searches, one for the spontaneous appearance of
pairs, another for a single , consistent with the decay of
a long-lived neutral particle into hadrons and an unseen neutral particle. For
the lowest level gluon-gluino bound state, known as the , we exclude the
decays and for
the masses of and in the theoretically allowed range. In
the most interesting mass range, , we exclude
lifetimes from seconds to as high as seconds,
assuming perturbative QCD production for the .Comment: 15 pages, 7 figure
A New Measurement of the Radiative Ke3 Branching Ratio and Photon Spectrum
We present a preliminary report on a new measurement of the radiative neutral
Ke3 branching ratio and the first study of the photon spectrum in this decay.
We find BR(Ke3g, E*_g>30 GeV, Th*_eg>20 deg)/BR(Ke3) =
0.911+-0.009(stat)+0.021-0.010(syst)%. Our measurement of the spectrum is
consistent with inner bremsstrahlung only as the source of photons at the 2
sigma level.Comment: 5 pages, 4 figures, proceedings paper from Meson 2000, Cracow,
Poland, May 200
Radiative Decay Width Measurements of Neutral Kaon Excitations Using the Primakoff Effect
We produce a sample consisting of 147 candidate events, with minimal
backgrounds, of the mixed axial vector pair K1(1270)-K1(1400) by exciting Kl's
in the Coulomb field of lead and report the first measurements of the radiative
widths Gamma_r(K1(1400)) = 280.8+-23.2(stat)+-40.4(syst) keV and
Gamma_r(K1(1270)) = 73.2+- 6.1(stat)+-28.3(syst) keV. We also place 90% CL
upper limits Gamma_r(K*(1410)) < 52.9 keV for the vector state and
Gamma_r(K2*(1430)) < 5.4 keV for the tensor state. These measurements allow for
significant tests of quark-model predictions of radiative widths for the
low-lying vector mesons.Comment: PRL-size article, 4 figure
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