Mortality and morbidity : the Matlab experience

Presents examples of how mortality and morbidity can be studied within a "small area". The possibility of grafting small studies at relatively little cost into a longitudinal system is described

Mortalité et morbidité : l'expérience de Matlab

Version anglaise disponible dans la Bibliothèque numérique du CRDI sous le titre: Mortality and morbidity : the Matlab experienc

Mesure et analyse de la mortalité : nouvelles approches

actes d'un séminaire international tenu à Sienne du 7 au 12 juillet 198

Sex differences in childhood mortality in rural Bangladesh

The issue of higher female than male mortality during childhood in developing countries has recently generated considerable interest. This paper presents additional evidence on this subject, based upon an analysis of longitudinal data from children in rural Bangladesh. Initially, the basis for higher female than male mortality in patriarchal societies is explored, and more specifically, the rationale for the differential valuation of male and female offspring. The pattern, timing and magnitude of sex differentials in mortality during infancy and early childhood is subsequently examined for children in our study. The paper concludes with a review of possible behavioral mechanisms which may contribute to higher female than male mortality during childhood.

Measles case fatality among the under-fives: A multivariate analysis of risk factors in a rural area of Bangladesh

This study investigated the relationship of measles case fatality among the under-fives with age, case type, complications, sex, mother's education, and household economic condition in a rural area of Bangladesh. A total of 3465 measles cases were detected during 1980 and 61 of them died of measles associated complications within 45 days of rash onset. Case type, sex, mother's education and household economic condition were found to have statistically significant impact on case fatality. Risk of death among the secondary cases was 1.87 times higher than in the primary cases, girls had 2.73 times higher risk of death than boys. Children of mothers without any formal schooling and those from the poorest households experienced 1.83 and 2.18 times higher risk of death than their counterparts whose mothers had at least one year of schooling and from economically better off households respectively.measles case fatality risk factors mother's education Bangladesh

Cyclic AMP-dependent Protein Kinase Regulates the Alternative Splicing of Tau Exon 10: A MECHANISM INVOLVED IN TAU PATHOLOGY OF ALZHEIMER DISEASE*

Hyperphosphorylation and deposition of tau into neurofibrillary tangles is a hallmark of Alzheimer disease (AD). Alternative splicing of tau exon 10 generates tau isoforms containing three or four microtubule binding repeats (3R-tau and 4R-tau), which are equally expressed in adult human brain. Dysregulation of exon 10 causes neurofibrillary degeneration. Here, we report that cyclic AMP-dependent protein kinase, PKA, phosphorylates splicing factor SRSF1, modulates its binding to tau pre-mRNA, and promotes tau exon 10 inclusion in cultured cells and in vivo in rat brain. PKA-Cα, but not PKA-Cβ, interacts with SRSF1 and elevates SRSF1-mediated tau exon 10 inclusion. In AD brain, the decreased level of PKA-Cα correlates with the increased level of 3R-tau. These findings suggest that a down-regulation of PKA dysregulates the alternative splicing of tau exon 10 and contributes to neurofibrillary degeneration in AD by causing an imbalance in 3R-tau and 4R-tau expression