Energy for a sustainable road/rail transport system in India

The main motivation for this study is that the strong transport-energy nexus has not received the attention it deserves, though energy is a crucial constraint on transport, and transport is a major determinant of energy demand. Also, many detailed treatments of the transport sector have not scrutinised the sustainability of the present pattern of development of this sector. Further, the prevailing paradigm guiding the development of the sector is made explicit and critiqued because it is often the root cause of its unsustainability. And, because treatments of transport policy issues tend to proceed without a clear statement of underlying goals and strategies, the entire hierarchy of interventions - from goals to strategies to policies - has been discussed. Finally, an attempt has been made to deal with both the supply and demand aspects of the transport sector. The study is restricted to road and rail transport since air and water (inland waters, and coastal and international seas) transport handle very small fractions of domestic traffic demand. The detailed discussions are preceded by overviews of the main features of the Indian transport system as well as of the energy sector as pertaining to transport. It is suggested that the goal of the Indian transport sector should be an efficient, capital-saving, non-import-intensive, affordable, service-oriented and environmentally sound transport system, i.e., a sustainable transport system. A strategy or broad plan to achieve this goal of a sustainable transport system should consist of several components: (1) minimisation of dependence on petroleum fuels, (2) maximisation of the level of safe, comfortable and time-saving transport services, (3) maximisation of the environmental soundness of the transport system, and in particular, reduction of local and global environmental pollution, (4) minimisation of the capital requirements for the transport modal mix that should also include non-motorised transport (NMT), and (5) minimisation of the energy used by the transport system without a reduction of the services provided. The detailed policies (plans or courses of action) to implement the above strategies for achieving a sustainable transport system fall into the following categories: (1) transport-energy database generation and use, (2) demand management, (3) technological improvements in road transport, (4) improvement of the capacity and quality of road infrastructure, (5) traffic management, (6) improvement of the railways, (7) improvement of urban transport, (8) providing a niche for non-motorised modes of transport, (9) pollution control and abatement, (10) costing and pricing, (11) modal shifts to achieve a least-cost freight modal mix, (12) modal shifts to achieve a least-cost passenger modal mix, (13) solutions to the transport sector's problems through measures in other sectors, (14) alternative fuels. Appropriate policy instruments or mechanisms for initiating and maintaining the policies as well as suitable policy agents to wield the policy instruments have also been identified. The market has the power of being an excellent allocator of money, materials and manpower, but unfortunately also has definite limits - it is not very good at looking after the poor, the environment, the long-term and the infrastructure and national strategic concerns such as self-reliance and external debt, all of which are of crucial relevance to the transport system. Hence, the visible hand of government and the people must complement the invisible hand of the market. In conclusion, both short-term low-cost measures to attract political decision-makers with short time-horizons and long-term measures have been mentioned. The short-term measures consist mainly of better maintenance, better driving practices, optimal routing of buses, dedicated routes for buses with traffic restrictions on these dedicated routes, special lanes for slow traffic, supply constraint on personal vehicles, export orientation to the production of personal vehicles, removal of kerosene and diesel subsidies, no long-haul truck permits, increase of truck taxes and shift of passengers travelling less than 300 km from rail to bus. The long-term measures consist mainly of increases in fuel efficiency, introduction of lower-power bus engines, increases in number of buses and/or suburban trains, investments on mass transportation infrastructure, home electrification, improvement of rail freight operations, truck-rail freight linkage, introduction of CNG for urban fleets, switches to biomass-derived fuels for transportation, biomass-derived fuels as petrol and diesel extenders, silviculture for biomass-derived fuels, and alternative cooking fuels and/or devices to replace kerosene

Integrated energy planning: Part II. Examples of DEFENDUS scenarios

The first part of this paper presented an ab initio exposition of the development-focused end-use oriented service-directed (DEFENDUS) approach to energy planning. In this approach, the future demand for any source of energy is estimated on the basis of the energy services required and the efficiency with which these are provided. To meet this demand, the costs per unit of the available energy-supply/saving technologies are estimated and a least-cost mix of options identified. In this second part, some of the energy studies for which the DEFENDUS method has been used are described to demonstrate that its applicability is not confined to a particular region or source of energy. These studies include: electricity for five states of India, petroleum products for the country as a whole, biomass for the state of Karnataka, and a composite energy scenario for Karnataka involving integration of all the currently-used sources of energy. In every case, the energy usage pattern in the commencement year of the plan, i.e., the total energy usage disaggregated between the existing categories of users according to their end-uses, is obtained. Then, depending on the goals selected and the strategies that could be adopted to achieve them, growth rates for each category of users are used to estimate the number of users in future years. Improvement in the efficiency of end-use devices and/or substitution of energy sources are considered, to determine the possible reduction in the category-wise unit energy usage, and the corresponding energy requirement is estimated. The electricity plan for the state of Karnataka comprises future demand estimation as well as the comparative costs of various supply/saving options. For the other states, electricity demand has been estimated in various scenarios. In the oil scenarios for India, the focus is mainly on demand management through modal and carrier shifts, with emphasis on the middle distillates. The biomass strategy for Karnataka includes both demand- and supply-side measures. All these studies show that the DEFENDUS planning procedure is easily amenable to modification according to the particular case under consideration. Further, the integration of worksheets for individual sources of energy demonstrates that this method, though simple, is capable of dealing with composite energy planning. Above all, with the popularity of personal computers and spreadsheet packages, the DEFENDUS method facilitates the democratization of energy planning

Spinal disease in myeloma: cohort analysis at a specialist spinal surgery centre indicates benefit of early surgical augmentation or bracing

BACKGROUND: Multiple myeloma osteolytic disease affecting the spine results in vertebral compression fractures. These are painful, result in kyphosis, and impact respiratory function and quality of life. We explore the impact of time to presentation on the efficacy of spinal treatment modalities. METHODS: We retrospectively reviewed 183 patients with spinal myeloma presenting to our service over a 2 year period. RESULTS: Median time from multiple myeloma diagnosis to presentation at our centre was 195 days. Eighty-four patients (45.9 %) were treated with balloon kyphoplasty and the remainder with a thoracolumbar-sacral orthosis as per our published protocol. Patients presenting earlier than 195 days from diagnosis had significant improvements in patient reported outcome measures: EuroQol 5-Dimensions (p < 0.001), Oswestry Disability Index (p < 0.001), and Visual Analogue Pain Score (p < 0.001) at follow-up, regardless of treatment. Patients presenting after 195 days, however, only experienced benefit following balloon kyphoplasty, with no significant benefit from non-operative management. CONCLUSION: Vertebral augmentation and thoracolumbar bracing improve patient reported outcome scores in patients with spinal myeloma. However, delay in treatment negatively impacts clinical outcome, particularly if managed non-operatively. It is important to screen and treat patients with MM and back pain early to prevent deformity and improve quality of life

An additional k-means clustering step improves the biological features of WGCNA gene co-expression networks

Background: Weighted Gene Co-expression Network Analysis (WGCNA) is a widely used R software package for the generation of gene co-expression networks (GCN). WGCNA generates both a GCN and a derived partitioning of clusters of genes (modules). We propose k-means clustering as an additional processing step to conventional WGCNA, which we have implemented in the R package km2gcn (k-means to gene co-expression network, https://github.com/juanbot/km2gcn). Results: We assessed our method on networks created from UKBEC data (10 different human brain tissues), on networks created from GTEx data (42 human tissues, including 13 brain tissues), and on simulated networks derived from GTEx data. We observed substantially improved module properties, including: (1) few or zero misplaced genes; (2) increased counts of replicable clusters in alternate tissues (x3.1 on average); (3) improved enrichment of Gene Ontology terms (seen in 48/52 GCNs) (4) improved cell type enrichment signals (seen in 21/23 brain GCNs); and (5) more accurate partitions in simulated data according to a range of similarity indices. Conclusions: The results obtained from our investigations indicate that our k-means method, applied as an adjunct to standard WGCNA, results in better network partitions. These improved partitions enable more fruitful downstream analyses, as gene modules are more biologically meaningful

Linker-free covalent immobilization of nisin using atmospheric pressure plasma induced grafting

The linker-free covalent immobilization of polymers on surfaces has the potential to impart new properties and functions to surfaces for a wide range of applications. However, most current methods for the production of these surfaces involve multiple chemical steps and do not have a high degree of control over the chemical functionalities at the surface. A comprehensive study detailing the facile two-step covalent grafting of the antimicrobial peptide nisin onto polystyrene surfaces is reported. Functionalization is achieved using an atmospheric pressure plasma jet, and the reaction is monitored and compared with a standard wet chemical functionalization approach using a variety of analytical techniques. The reactive species produced by the atmospheric pressure plasma jet were analyzed by mass spectrometry and optical emission spectroscopy. The surface chemistry and topography of the functionalized surfaces were determined using contact angle measurements, Fourier infrared spectroscopy (FTIR), X-ray photoelectron spectroscopy and atomic force microscopy respectively. Following surface analysis, the antimicrobial efficacy of the covalently grafted nisin against two major food borne pathogens (Staphylococcus aureus and Listeria monocytogenes) was assessed at two different pHs. The results demonstrated that a post-plasma treatment step after nisin deposition is required to covalently graft the peptide onto the surface. The covalent immobilization of nisin resulted in a significant reduction in bacterial counts within a short 30 minutes contact time. These surfaces were also significantly more antimicrobial compared to those prepared via a more traditional wet chemical approach indicating that the reported method could be a less expensive and less time consuming alternative

Fluorescence, pigment and microscopic characterization of Bering Sea phytoplankton community structure and photosynthetic competency in the presence of a Cold Pool during summer

Spectral fluorescence measurements of phytoplankton chlorophyll a (Chl a), phytoplankton phycobilipigments and variable fluorescence (Fv/Fm), are utilized with High Performance Liquid Chromatography (HPLC) estimates of phytoplankton pigments and microscopic cells counts to construct a comprehensive picture of summer-time phytoplankton communities and their photosynthetic competency in the eastern Bering Sea shelf. Although the Bering Sea was ice-free during our study, the exceptionally cold winter that preceded the summer of 2008 when our cruise took place, facilitated the formation of a “Cold Pool” (<2 °C) and its entrapment at depth in the northern middle shelf. The presence of a strong pycnocline over the entire middle and outer shelves restricted inorganic nutrient fluxes into the surface waters resulting in phytoplankton populations that were photo-physiologically stressed due to nutrient limitation. Elevated Chl a concentrations recorded in the Green Belt along the shelf edge of the Bering Sea, were due to Phaeocystis pouchetii and nano-sized cryptophytes. Although inorganic nutrients were not limiting in the Green Belt, Fv/Fm values were low in all probability due to iron limitation. Phytoplankton communities in the low biomass surface waters of the middle shelf were comprised of prasinophytes, haptophytes, cryptophytes and diatoms. In the northern part of the middle shelf, a sinking bloom made up of the centric diatoms Chaeotoceros socialis, Thalassiosira nordenskioeldii and Porosira glacialis was located above the Cold Pool. The high biomass associated with this senescent bloom and its accretion above the pycnocline, suggests that the Cold Pool acts as a barrier, preventing sinking phytoplankton from reaching the bottom where they can become available to benthic organisms. We further posit that if summer-time storms are not energetic enough and the Cold Pool is not eroded, its presence facilitates the transfer of the large spring phytoplankton bloom to the pelagic ecosystem

Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage.

Knowledge of genomic features specific to the human lineage may provide insights into brain-related diseases. We leverage high-depth whole genome sequencing data to generate a combined annotation identifying regions simultaneously depleted for genetic variation (constrained regions) and poorly conserved across primates. We propose that these constrained, non-conserved regions (CNCRs) have been subject to human-specific purifying selection and are enriched for brain-specific elements. We find that CNCRs are depleted from protein-coding genes but enriched within lncRNAs. We demonstrate that per-SNP heritability of a range of brain-relevant phenotypes are enriched within CNCRs. We find that genes implicated in neurological diseases have high CNCR density, including APOE, highlighting an unannotated intron-3 retention event. Using human brain RNA-sequencing data, we show the intron-3-retaining transcript to be more abundant in Alzheimer's disease with more severe tau and amyloid pathological burden. Thus, we demonstrate potential association of human-lineage-specific sequences in brain development and neurological disease