Follow-up after curative resection for gastric cancer. Is it time to tailor it?

There is still no consensus on the follow-up frequency and regimen after curative resection for gastric cancer. Moreover, controversy exists regarding the utility of follow-up in improving survival, and the recommendations of experts and societies vary considerably. The main reason to establish surveillance programs is to diagnose tumor recurrence or metachronous cancers early and to thereby provide prompt treatment and prolong survival. In the setting of gastric malignancies, other reasons have been put forth: (1) the detection of adverse effects of a previous surgery, such as malnutrition or digestive sequelae; (2) the collection of data; and (3) the identification of psychological and/or social problems and provision of appropriate support to the patients. No randomized controlled trials on the role of follow-up after curative resection of gastric carcinoma have been published. Herein, the primary retrospective series and systematic reviews on this subject are analyzed and discussed. Furthermore, the guidelines from international and national scientific societies are discussed. Follow-up is recommended by the majority of institutions; however, there is no real evidence that follow-up can improve long-term survival rates. Several studies have demonstrated that it is possible to stratify patients submitted to curative gastrectomy into different classes according to the risk of recurrence. Furthermore, promising studies have identified several molecular markers that are related to the risk of relapse and to prognosis. Based on these premises, a promising strategy will be to tailor follow-up in relation to the patient and tumor characteristics, molecular marker status, and individual risk of recurrence

Astrophysics in S.Co.P.E

S.Co.P.E. is one of the four projects funded by the Italian Government in order to provide Southern Italy with a distributed computing infrastructure for fundamental science. Beside being aimed at building the infrastructure, S.Co.P.E. is also actively pursuing research in several areas among which astrophysics and observational cosmology. We shortly summarize the most significant results obtained in the first two years of the project and related to the development of middleware and Data Mining tools for the Virtual Observatory

Dystonia: sparse synapses for D2 receptors in striatum of a DYT1 knock-out mouse model

Dystonia pathophysiology has been partly linked to downregulation and dysfunction of dopamine D2 receptors in striatum. We aimed to investigate the possible morpho-structural correlates of D2 receptor downregulation in the striatum of a DYT1 Tor1a mouse model. Adult control Tor1a+/+ and mutant Tor1a+/− mice were used. The brains were perfused and free-floating sections of basal ganglia were incubated with polyclonal anti-D2 antibody, followed by secondary immune-fluorescent antibody. Confocal microscopy was used to detect immune-fluorescent signals. The same primary antibody was used to evaluate D2 receptor expression by western blot. The D2 receptor immune-fluorescence appeared circumscribed in small disks (~0.3–0.5 μm diameter), likely representing D2 synapse aggregates, densely distributed in the striatum of Tor1a+/+ mice. In the Tor1a+/− mice the D2 aggregates were significantly smaller (μm2 2.4 ± SE 0.16, compared to μm2 6.73 ± SE 3.41 in Tor1a+/+) and sparse, with ~30% less number per microscopic field, value correspondent to the amount of reduced D2 expression in western blotting analysis. In DYT1 mutant mice the sparse and small D2 synapses in the striatum may be insufficient to “gate” the amount of presynaptic dopamine release diffusing in peri-synaptic space, and this consequently may result in a timing and spatially larger nonselective sphere of influence of dopamine action

Type I Planet Migration in Nearly Laminar Disks

We describe 2D hydrodynamic simulations of the migration of low-mass planets ($\leq 30 M_{\oplus}$) in nearly laminar disks (viscosity parameter $\alpha < 10^{-3}$) over timescales of several thousand orbit periods. We consider disk masses of 1, 2, and 5 times the minimum mass solar nebula, disk thickness parameters of $H/r = 0.035$ and 0.05, and a variety of $\alpha$ values and planet masses. Disk self-gravity is fully included. Previous analytic work has suggested that Type I planet migration can be halted in disks of sufficiently low turbulent viscosity, for $\alpha \sim 10^{-4}$. The halting is due to a feedback effect of breaking density waves that results in a slight mass redistribution and consequently an increased outward torque contribution. The simulations confirm the existence of a critical mass ($M_{cr} \sim 10 M_{\oplus}$) beyond which migration halts in nearly laminar disks. For \alpha \ga 10^{-3}, density feedback effects are washed out and Type I migration persists. The critical masses are in good agreement with the analytic model of Rafikov (2002). In addition, for \alpha \la 10^{-4} steep density gradients produce a vortex instability, resulting in a small time-varying eccentricity in the planet's orbit and a slight outward migration. Migration in nearly laminar disks may be sufficiently slow to reconcile the timescales of migration theory with those of giant planet formation in the core accretion model.Comment: 3 figures, accepted to ApJ

X-ray and UV correlation in the quiescent emission of Cen X-4, evidence of accretion and reprocessing

We conducted the first long-term (60 days), multiwavelength (optical, ultraviolet, and X-ray) simultaneous monitoring of Cen X-4 with daily Swift observations, with the goal of understanding variability in the low mass X-ray binary Cen X-4 during quiescence. We found Cen X-4 to be highly variable in all energy bands on timescales from days to months, with the strongest quiescent variability a factor of 22 drop in the X-ray count rate in only 4 days. The X-ray, UV and optical (V band) emission are correlated on timescales down to less than 110 s. The shape of the correlation is a power law with index gamma about 0.2-0.6. The X-ray spectrum is well fitted by a hydrogen NS atmosphere (kT=59-80 eV) and a power law (with spectral index Gamma=1.4-2.0), with the spectral shape remaining constant as the flux varies. Both components vary in tandem, with each responsible for about 50% of the total X-ray flux, implying that they are physically linked. We conclude that the X-rays are likely generated by matter accreting down to the NS surface. Moreover, based on the short timescale of the correlation, we also unambiguously demonstrate that the UV emission can not be due to either thermal emission from the stream impact point, or a standard optically thick, geometrically thin disc. The spectral energy distribution shows a small UV emitting region, too hot to arise from the accretion disk, that we identified as a hot spot on the companion star. Therefore, the UV emission is most likely produced by reprocessing from the companion star, indeed the vertical size of the disc is small and can only reprocess a marginal fraction of the X-ray emission. We also found the accretion disc in quiescence to likely be UV faint, with a minimal contribution to the whole UV flux.Comment: 5 pages, 4 figures, submitted to Proc. Int. Conf. Physics at the Magnetospheric Boundary, Geneva, Switzerland (25-28 June, 2013

Modeling the resonant planetary system GJ876

The two planets about the star GJ 876 appear to have undergone extensive migration from their point of origin in the protoplanetary disk -- both because of their close proximity to the star (30 and 60 day orbital periods) and because of their occupying three stable orbital resonances at the 2:1 mean-motion commensurability. The resonances were most likely established by converging differential migration of the planets leading to capture into the resonances. A problem with this scenario is that continued migration of the system while it is trapped in the resonances leads to orbital eccentricities that rapidly exceed the observational upper limits of e_1 = 0.31 and e_2 = 0.05. As seen in forced 3-body simulations, lower eccentricities would persist during migration only for an applied eccentricity damping. Here we explore the evolution of the GJ 876 system using two-dimensional hydrodynamical simulations that include viscous heating and radiative effects. We find that a hydrodynamic evolution within the resonance, where only the outer planet interacts with the disk, always rapidly leads to large values of eccentricities that exceed those observed. Only if mass is removed from the disk on a time scale of the order of the migration time scale (before there has been extensive migration after capture), as might occur for photoevaporation in the late phases of planet formation, can we end up with eccentricities that are consistent with the observations.Comment: Paper accepted by A&A, 17 Pages, 17 Figure

Two-photon diffraction and quantum lithography

We report a proof-of-principle experimental demonstration of quantum lithography. Utilizing the entangled nature of a two-photon state, the experimental results have bettered the classical diffraction limit by a factor of two. This is a quantum mechanical two-photon phenomenon but not a violation of the uncertainty principle.Comment: 5 pages, 5 figures Submitted to Physical Review Letter

Daily, multiwavelength Swift monitoring of the neutron star low-mass X-ray binary Cen X-4: evidence for accretion and reprocessing during quiescence

We conducted the first long-term (60 days), multiwavelength (optical, ultraviolet, and X-ray) simultaneous monitoring of Cen X-4 with daily Swift observations from June to August 2012, with the goal of understanding variability in the low mass X-ray binary Cen X-4 during quiescence. We found Cen X-4 to be highly variable in all energy bands on timescales from days to months, with the strongest quiescent variability a factor of 22 drop in the X-ray count rate in only 4 days. The X-ray, UV and optical (V band) emission are correlated on timescales down to less than 110 s. The shape of the correlation is a power law with index gamma about 0.2-0.6. The X-ray spectrum is well fitted by a hydrogen NS atmosphere (kT=59-80 eV) and a power law (with spectral index Gamma=1.4-2.0), with the spectral shape remaining constant as the flux varies. Both components vary in tandem, with each responsible for about 50% of the total X-ray flux, implying that they are physically linked. We conclude that the X-rays are likely generated by matter accreting down to the NS surface. Moreover, based on the short timescale of the correlation, we also unambiguously demonstrate that the UV emission can not be due to either thermal emission from the stream impact point, or a standard optically thick, geometrically thin disc. The spectral energy distribution shows a small UV emitting region, too hot to arise from the accretion disk, that we identified as a hot spot on the companion star. Therefore, the UV emission is most likely produced by reprocessing from the companion star, indeed the vertical size of the disc is small and can only reprocess a marginal fraction of the X-ray emission. We also found the accretion disc in quiescence to likely be UV faint, with a minimal contribution to the whole UV flux.Comment: 19 pages, 6 figures, 4 table