7 research outputs found
Investigating Intergenerational Differences in Human PCB Exposure due to Variable Emissions and Reproductive Behaviors
Background: Reproductive behaviors (such as age of childbearing, parity, and breastfeeding prevalence) have changed over the same historical time period as PCB emissions and may produce intergenerational differences in human PCB exposure. Objectives: To estimate prenatal, postnatal, and lifetime PCB exposures for women at different ages according to year of birth and evaluate the impact of reproductive characteristics on intergenerational differences in exposure. Methods: The time-variant mechanistic model CoZMoMAN was used to calculate human bioaccumulation of PCBs assuming both hypothetical constant and realistic time-variant emissions. Results: Although exposure mostly depends upon when an individual was born relative to the emission history of PCBs, reproductive behaviors can have a significant impact. Our model suggests that a mother’s reproductive history has a greater influence on the prenatal and postnatal exposures of her children than it does on her own cumulative lifetime exposure. In particular, a child’s birth order appears to have a strong influence on their prenatal exposure, whereas postnatal exposure is determined by the type of milk (formula or breast milk) fed to the infant. Conclusions: Prenatal PCB exposure appears to be delayed relative to the time of PCB emissions, particularly among those born after the PCB production phase-out. Consequently, the health repercussions of environmental PCBs can be expected to persist for several decades, despite bans on their production for over 40 years