Adenomatoid odontogenic tumour

A case of adenomatoid odontogenic tumour (AOT) is presented with a short review of clinical, radiological and histological features

Endolymphatic sac tumour (ELST). Case report of a rare tumour of the temporal bone, presenting as a mass in a cerebello-pontine angle

Endolymphatic sac tumour (ELST) is a primary low-grade, locally invasive adenocarcinoma of the endolymphatic sac, characterized by the proliferation of cuboidal cells forming a papillotubular pattern and colloid-filled cysts. Rare in the general population, it coincides significantly with the presence of von Hippel-Lindau disease. The natural history, mechanisms underlying the early symptoms, anatomical origin of ELST and optimal timing of their treatment are unknown. In this study, we report a Polish male patient with sporadic ELST (without a family history of VHL disease) along with a review of literature. The light microscopic and immunohistochemical features as well as clinical presentation were typical of ELST

HER-3 expression in HER-2-amplified breast carcinoma

AIM OF THE STUDY: To determine whether the expression of HER-3 influences the survival of HER-2 positive patients with breast cancer (BC). MATERIAL AND METHODS: In the present work, the expression of HER-3 in a group of 35 HER-2 positive patients with BC was studied by performing immunohistochemistry (IHC) in formalin-fixed paraffin embedded tissues. RESULTS: Higher HER-3 status if estimated by IHC correlated significantly with older age of the patients. HER-3 expression did not correlate with estrogen or progesterone receptor status, pT or pN. There was also no significant difference in disease-free or overall survival (DFS and OS) between groups with different HER-3 expression, although some tendencies were seen as HER-3 expression in over 50% of cells was a factor of worse 5- and 10-year survival. CONCLUSIONS: Further studies should be performed on a larger group of patients to confirm the prognostic role of HER-3 status determined by IHC in BC

Evaluation of antiarrythmic activity of novel imidazo[2,1-F]purine-2,4-dione and imidazolidine-2,4-dione derivatives with aminoalkyl moieties

The main goal of this study was to assess antiarrhythmic activity of novel aminoalkyl derivatives of imidazo[2,1-f]purine-2,4-dione and imidazolidine-2,4-dione exerting α1 and 5-HT1A receptors affinity. Tested compounds produced prophylactic and therapeutic antiarrhythmic activity in an adrenaline-induced model of arrhythmia. The strongest antiarrhythmic activity as well as the highest α1-adrenoreceptor affinity (Ki = 13.9 nM) was found for 5-methyl-5-phenyl-3-[3-(4-(2-methoxyphenyl)piperazin-1-yl)propyl]-imidazolidine-2,4- dione (12). The results indicated a correlation between α1-adrenoreceptor affinities and antiarrhythmic activity

Exhaust Noise Reduction by Application of Expanded Collecting System in Pneumatic Tools and Machines

In this paper, we demonstrate how to reduce the noise level of expanded air from pneumatic tools. Instead of a muffler, we propose the expanded collecting system, where the air expands through the pneumatic tube and expansion collector. We have elaborated a mathematical model which illustrates the dynamics of the air flow, as well as the acoustic pressure at the end of the tube. The computational results were compared with experimental data to check the air dynamics and sound pressure. Moreover, the study presents the methodology of noise measurement generated in a pneumatic screwdriver in a quiet back room and on a window-fitting stand in a production hall. In addition, we have performed noise measurements for the pneumatic screwdriver and the pneumatic screwdriver on an industrial scale. These measurements prove the noise reduction of the pneumatic tools when the expanded collecting system is used. When the expanded collecting system was applied to the screwdriver, the measured Sound Pressure Level (SPL) decreased from 87 to 80 dB(A)