Coupling undetected sensing modes by quantum erasure

The effect known as ``induced coherence without induced emission'' has spawned a field dedicated to imaging with undetected photons (IUP), where photons from two distinct photon-pair sources interfere if their outputs are made indistinguishable. The indistinguishability is commonly achieved in two setups. Induced coherence IUP (IC-IUP) has only the idler photons from the first source passing through the second, whilst nonlinear interferometry (NI-IUP) has both signal and idler photons from the first source passing through the second and can be simpler to implement. In both cases, changes in the idler path between sources can be detected by measuring the interference fringes in the signal path in a way that allows image information to be moved between different wavelengths. Here we model and implement a novel setup that uses a polarization state quantum eraser approach to move continuously between IC-IUP and NI-IUP operation. We find excellent agreement between experiment and theory in the low-gain or quantum regime. The system also provides a new route for optimizing IUP interference by using controllable quantum erasure to balance the interferometer

Synthesis and Biological Evaluation of a Novel Pentagastrin-Toxin Conjugate Designed for a Targeted Prodrug Mono-therapy of Cancer

A novel carbamate prodrug 2 containing a pentagastrin moiety was synthesized. 2 was designed as a detoxified analogue of the highly cytotoxic natural antibiotic duocarmycin SA (1) for the use in a targeted prodrug monotherapy of cancers expressing cholecystokinin (CCK-B)/gastrin receptors. The synthesis of prodrug 2 was performed using a palladium-catalyzed carbonylation of bromide 6, followed by a radical cyclisation to give the pharmacophoric unit 10, coupling of 10 to the DNA-binding subunit 15 and transformation of the resulting seco-drug 3b into the carbamate 2 via addition of a pentagastrin moiety

Loss-Compensated and Enhanced Midinfrared Interaction-Free Sensing with Undetected Photons

Sensing with undetected photons enables the measurement of absorption and phase shifts at wavelengths different from those detected. Here, we experimentally map the balance and loss parameter space in a nondegenerate nonlinear interferometer, showing the recovery of sensitivity despite internal losses at the detection wavelength. We further explore an interaction-free operation mode with a detector-to-sample incident optical power ratio of over 200. This allows changes in attowatt levels of power at 3.4 μ m wavelength to be detected at 1550 nm, immune to the level of thermal black-body background. This reveals an ultrasensitive infrared imaging methodology capable of probing samples effectively “in the dark.

Major results from the first plasma campaign of the Wendelstein 7-X stellarator

After completing the main construction phase of Wendelstein 7-X (W7-X) and successfully commissioning the device, first plasma operation started at the end of 2015. Integral commissioning of plasma start-up and operation using electron cyclotron resonance heating (ECRH) and an extensive set of plasma diagnostics have been completed, allowing initial physics studies during the first operational campaign. Both in helium and hydrogen, plasma breakdown was easily achieved. Gaining experience with plasma vessel conditioning, discharge lengths could be extended gradually. Eventually, discharges lasted up to 6 s, reaching an injected energy of 4 MJ, which is twice the limit originally agreed for the limiter configuration employed during the first operational campaign. At power levels of 4 MW central electron densities reached 3 1019 m-3, central electron temperatures reached values of 7 keV and ion temperatures reached just above 2 keV. Important physics studies during this first operational phase include a first assessment of power balance and energy confinement, ECRH power deposition experiments, 2nd harmonic O-mode ECRH using multi-pass absorption, and current drive experiments using electron cyclotron current drive. As in many plasma discharges the electron temperature exceeds the ion temperature significantly, these plasmas are governed by core electron root confinement showing a strong positive electric field in the plasma centre.Peer reviewe