Feasibility evaluation of construction methods specified in design documentation

W pracy przedstawiono propozycję oceny rozwiązań projektowych (dokumentacji projektowej) pod względem technologiczności realizacji zaprojektowanych obiektów, to jest pod względem możliwości sprawnego i efektywnego wykonania zaprojektowanych budynków, z uwzględnieniem podstawowych wymagań technologiczno- organizacyjnych. Zaproponowano model oceny punktowej, uwzględniający siedem zdefiniowanych kryteriów oceny i przeznaczony w szczególności dla oceny projektów wielorodzinnych budynków mieszkalnych.The evaluation of building design documentation is usually limited to consideration of cost and duration of works needed to execute a designed object. However, factors as safety of works, extent of mechanization of works, and other good or bad sides of construction methods needed to be implemented as per the analyzed design, are also considered, but normally without any measures. The method presented in this paper allows to evaluate the construction methods, as specified in the analyzed design documentation, using the points assigned to seven defined evaluation criteria. The final, total number of points represents the technological quality and feasibility of the construction processes and materials specified in the evaluated design documentation

Influence of the Bioactive Diet Components on the Gene Expression Regulation

Diet bioactive components, in the concept of nutrigenetics and nutrigenomics, consist of food constituents, which can transfer information from the external environment and influence gene expression in the cell and thus the function of the whole organism. It is crucial to regard food not only as the source of energy and basic nutriments, crucial for living and organism development, but also as the factor influencing health/disease, biochemical mechanisms, and activation of biochemical pathways. Bioactive components of the diet regulate gene expression through changes in the chromatin structure (including DNA methylation and histone modification), non-coding RNA, activation of transcription factors by signalling cascades, or direct ligand binding to the nuclear receptors. Analysis of interactions between diet components and human genome structure and gene activity is a modern approach that will help to better understand these relations and will allow designing dietary guidances, which can help maintain good health

Optimization of Phenolic Compounds Extraction from Flax Shives and Their Effect on Human Fibroblasts

The goal of this study was to evaluate the most effective technique for extraction of phenolics present in flax shives and to assess their effect on human fibroblasts. Flax shives are by-products of fibre separation, but they were found to be a rich source of phenolic compounds and thus might have application potential. It was found that the optimal procedure for extraction of phenolics was hydrolysis enhanced by the ultrasound with NaOH for 24 h at 65°C and subsequent extraction with ethyl acetate. The influence of the flax shives extract on fibroblast growth and viability was assessed using the MTT and SRB tests. Moreover, the influence of flax shives extract on the extracellular matrix remodelling process was verified. The 20% increase of the viability was observed upon flax shives extract treatment and the decrease of mRNA collagen genes, an increase of matrix metalloproteinase gene expression, and reduction in levels of interleukin 6, interleukin 10, and suppressor of cytokinin signaling 1 mRNA were observed. Alterations in MCP-1 mRNA levels were dependent on flax shives extract concentration. Thus, we suggested the possible application of flax shives extract in the wound healing process