Artificial Intelligence as a Substitute for Human Creativity

Creativity has always been perceived as a human trait, even though the exact neural mechanisms remain unknown, it has been the subject of research and debate for a long time. The recent development of AI technologies and increased interest in AI has led to many projects capable of performing tasks that have been previously regarded as impossible without human creativity. Music composition, visual arts, literature, and science represent areas in which these technologies have started to both help and replace the creative human, with the question of whether AI can be creative and capable of creation more realistic than ever. This review aims to provide an extensive perspective over several state-of-the art technologies and applications based on AI which are currently being implemented into areas of interest closely correlated to human creativity, as well as the economic impact the development of such technologies might have on those domains

Bidirectional Relationship Between Reduced Blood pH and Acute Pancreatitis: A Translational Study of Their Noxious Combination

Acute pancreatitis (AP) is often accompanied by alterations in the acid-base balance, but how blood pH influences the outcome of AP is largely unknown. We studied the association between blood pH and the outcome of AP with meta-analysis of clinical trials, and aimed to discover the causative relationship between blood pH and AP in animal models. PubMed, EMBASE, and Cochrane Controlled Trials Registry databases were searched from inception to January 2017. Human studies reporting systemic pH status and outcomes (mortality rate, severity scores, and length of hospital stay) of patient groups with AP were included in the analyses. We developed a new mouse model of chronic metabolic acidosis (MA) and induced mild or severe AP in the mice. Besides laboratory blood testing, the extent of pancreatic edema, necrosis, and leukocyte infiltration were assessed in tissue sections of the mice. Thirteen studies reported sufficient data in patient groups with AP (n = 2,311). Meta-analysis revealed markedly higher mortality, elevated severity scores, and longer hospital stay in AP patients with lower blood pH or base excess (P < 0.001 for all studied outcomes). Meta-regression analysis showed significant negative correlation between blood pH and mortality in severe AP. In our mouse model, pre-existing MA deteriorated the pancreatic damage in mild and severe AP and, vice versa, severe AP further decreased the blood pH of mice with MA. In conclusion, MA worsens the outcome of AP, while severe AP augments the decrease of blood pH. The discovery of this vicious metabolic cycle opens up new therapeutic possibilities in AP

Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis : a cross-sectional multicentre international study with experimental animal model

Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n=983), recurrent AP (RAP, n=270) and CP (n=62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5+was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3+do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.Peer reviewe

Advanced Techniques for Monitoring and Management of Urban Water Infrastructures—An Overview

Water supply systems are essential for a modern society. This article presents an overview of the latest research related to information and communication technology systems for water resource monitoring, control and management. The main objective of our review is to show how emerging technologies offer support for smart administration of water infrastructures. The paper covers research results related to smart cities, smart water monitoring, big data, data analysis and decision support. Our evaluation reveals that there are many possible solutions generated through combinations of advanced methods. Emerging technologies open new possibilities for including new functionalities such as social involvement in water resource management. This review offers support for researchers in the area of water monitoring and management to identify useful models and technologies for designing better solutions

Gazdasagi szerkezet es versenykepesseg az EU csatlakozas utan: A VIII. Ipar- es Vallalatgazdasagi konferencia eloadasai (Proceedings of Economic structure and competitiveness in the EU after accession VIII), Pecs, Hungary, 21-22 October 2004

Proceedings of 'Economic structure and competitiveness in the EU after accession VIII', held in Pecs, Hungary, from 21 to 22 October 2004