Empowerment et système de justice pénale : l'expérience des victimes d'actes criminels

Thèse numérisée par la Division de la gestion de documents et des archives de l'Université de Montréal

Les facteurs influençant la satisfaction des victimes dans un processus de médiation

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal

Amyloid in neurodegenerative diseases: Friend or foe?

Accumulation of amyloid-like aggregates is a hallmark of numerous neurodegenerative disorders such as Alzheimer’s and polyglutamine disease. Yet, whether the amyloid inclusions found in these diseases are toxic or cytoprotective remains unclear. Various studies suggest that the toxic culprit in the amyloid folding pathway is actually a soluble oligomeric species which might interfere with normal cellular function by a multifactorial mechanism including aberrant protein-protein interactions. Molecular chaperones suppress toxicity of amyloidogenic proteins by inhibiting aggregation of non-native disease substrates and targeting them for refolding or degradation. Paradoxically, recent studies also suggest a protective action of chaperones in their promotion of the assembly of large, tightly packed, benign aggregates that sequester toxic protein species

Southern Ocean food-webs and climate change:A short review and future directions

Food-webs are a critical feature of ecosystems and help us understand how communities will respond to climate change. The Southern Ocean is facing rapid and accelerating changes due to climate change. Though having evolved in an isolated and somewhat extreme environment, Southern Ocean biodiversity and food-webs are among the most vulnerable. Here, we review 1) current knowledge on Southern Ocean food-webs; 2) methods to study food-webs; 3) assessment of current and future impacts of climate change on Southern Ocean food-webs; 4) knowledge gaps; and 5) the role of Early Career Researchers (ECRs) in future studies. Most knowledge on Southern Ocean food-webs come from the pelagic environment, both at macro- and microbial levels. Modelling and diet studies of individual species are major contributors to the food-web knowledge. These studies revealed a short food-web, predominantly sustained by Antarctic Krill (Euphausia superba). Additionally, alternative pathways exist, involving other krill species, fish, and squid, which play equally important roles in connecting primary producers with top predators. Advantages and disadvantages of several techniques used to study Southern Ocean food-webs were identified, from the classical analyses of stomach contents, scats, or boluses to the most recent approaches such as metabarcoding and trophic-biomarkers. Observations show that climate change can impact the food-web in different ways. As an example, changes to smaller phytoplankton species can lengthen the food-web, increasing assimilation losses and/or changing nutrient cycles. Future studies need to focus on the benthic-dominated food-webs and the benthopelagic coupling. Furthermore, research during the winter season and below the ice-shelves is needed as these areas may play a crucial role in the functioning of this ecosystem. ECRs can play a significant role in advancing the study of Southern Ocean food-webs due to their willingness for interdisciplinary collaboration and proficiency in employing various methodologies, contributing to the construction of high-resolution food-webs

The Hsp70/90 cochaperone, Sti1, suppresses proteotoxicity by regulating spatial quality control of amyloid-like proteins

Escape of aberrant proteins from protein quality control leads to accumulation of toxic protein species. Sti1 interacts with Hsp70 to mediate spatial PQC of amyloid-like proteins by regulating their distribution in different intracellular protein-handling depots. Sti1 suppresses proteotoxicity by targeting amyloid-like proteins to perinuclear foci.Conformational diseases are associated with the conversion of normal proteins into aggregation-prone toxic conformers with structures similar to that of β-amyloid. Spatial distribution of amyloid-like proteins into intracellular quality control centers can be beneficial, but cellular mechanisms for protective aggregation remain unclear. We used a high-copy suppressor screen in yeast to identify roles for the Hsp70 system in spatial organization of toxic polyglutamine-expanded Huntingtin (Huntingtin with 103Q glutamine stretch [Htt103Q]) into benign assemblies. Under toxic conditions, Htt103Q accumulates in unassembled states and speckled cytosolic foci. Subtle modulation of Sti1 activity reciprocally affects Htt toxicity and the packaging of Htt103Q into foci. Loss of Sti1 exacerbates Htt toxicity and hinders foci formation, whereas elevation of Sti1 suppresses Htt toxicity while organizing small Htt103Q foci into larger assemblies. Sti1 also suppresses cytotoxicity of the glutamine-rich yeast prion [RNQ+] while reorganizing speckled Rnq1–monomeric red fluorescent protein into distinct foci. Sti1-inducible foci are perinuclear and contain proteins that are bound by the amyloid indicator dye thioflavin-T. Sti1 is an Hsp70 cochaperone that regulates the spatial organization of amyloid-like proteins in the cytosol and thereby buffers proteotoxicity caused by amyloid-like proteins

The Grizzly, October 29, 1982

Violence in Girls\u27 Dorm: Collegian Suspended After Fight • Managerial Communications Workshop Offered to Ursinus Students • Ursinus College Bowl Returns • Hazard and His Heroes to Rock Helfferich Hall • Letters to the Editor: Making Mountains Out of Food Hills; Please Live in Dorms • President\u27s Corner • Registration: A Game of Luck, Chance and Daring • Lewis on Wall Street • USGA Plans Activities • Sports Profile: Overcoming Adversity Beener-style • Diplomats Dump the Grizzlies • Booters Bearly Beat Muhlenberg • Lady Bears Drop One to Rival West Chesterhttps://digitalcommons.ursinus.edu/grizzlynews/1086/thumbnail.jp

The Grizzly, September 28, 1984

Limerick: Nuclear Power Comes to Montgomery County • Communication Arts\u27 Newest Member • News of Yesteryear: Is There a Ghost in UC\u27s Haunted Hall? • Shorts: PA German Studies; Political Ad Forum; Appointment • Soccer Rebounds From Loss to Drexel • X-Country Competes in Invitational • Hockey Player Named to US Squad • Pro Football Wrap-Up • Grizzlies Lose to W. Marylandhttps://digitalcommons.ursinus.edu/grizzlynews/1122/thumbnail.jp

The Grizzly, October 15, 1982

Students for Peace and Progress Get Started • Homecoming 1982 • Annual Parents Day a Success • Letters to the Editor • Opinion: Sorority Rushing Needs Revision • Lantern Format Undecided • Dance-a-Thon for Lupus • Japan: Big and Real • New Art at Myrin • Bear Booters Win Three • Now Hold it Just a Minute! • Grizzlies Win Third Straight • X-Country Wins • Penn Blasts Lady Bears 3-0https://digitalcommons.ursinus.edu/grizzlynews/1084/thumbnail.jp

The Grizzly, November 12, 1982

Nobel Prize Winner at Ursinus • Tray Contest at Wismer • Life in the Fast Lane • International Accord Signed • Berry Brings About Changes • Eclectic Exhibit • President\u27s Corner • Registrar Announces Finals Schedule • Stallone Knocked Out in First Blood • From Bar to Bard • UPB Bus to New Market • No Encore, Please • Immersion Excursion • USGA Notes • Frostburg Freezes UC in ECAC Playoffs • Field Hockey Ends Season at .500 • Career Options Presented • Grizzlies Drop Season Finale to Widener • Harriers Take Second in MAC Meethttps://digitalcommons.ursinus.edu/grizzlynews/1088/thumbnail.jp

The Grizzly, November 8, 1985

Snyder Holds New Chair of Physics • Internships Problematic, but Necessary • Founder\u27s Day Filled with Science • Letters: The Good and Bad of Security • Science Makes its Stand in Liberal Arts Programs • In Search of Success: Jackson • Parsons Adds a Touch of Dutch Country • Playing Red/Gold in Recruitment • Freshman Urged to Begin Career Planning • Key Issues • Booters Play the Bridesmaid Again • Lady Bears Off to ECAC for Another Time • Bad Luck Strikes the Grizzlies • Box Lacrosse Popularity Grows • Successful Search for Liberal Arts Students • The Stand • Athlete of the Week • Education Department Offers Teaching Internshiphttps://digitalcommons.ursinus.edu/grizzlynews/1151/thumbnail.jp