16 research outputs found

    Oncological and functional outcomes following open radical prostatectomy: how patients may achieve the "trifecta"?

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    PURPOSE: The desirable outcomes after open radical prostatectomy (RP) for localized prostate cancer (PC) are to: a) achieve disease recurrence free, b) urinary continence (UC), and c) maintain sexual potency (SP). These 3 combined desirable outcomes we called it the "Trifecta". Our aim is to assess the likelihood of achieving the Trifecta, and to analyze the influencing the Trifecta . MATERIALS AND METHODS: A total of 1738 men with localized PC underwent RP from 1992-2007 by a single surgeon. The exclusion criteria for this analysis were: preoperative hormonal or radiation therapy, preoperative urinary incontinence or erectile dysfunction, follow-up less than 24 months or insufficient data. Post-operative Trifecta factors were analyzed, including biochemical recurrence (BR).. We defined: BR as PSA > 0.2 ng/mL, urinary continence as wearing no pads, and sexual potency as having erections sufficient for intercourse with or without a phosphodiesterase-5 inhibitor. RESULTS: A total of 831 patients met the inclusion criteria. The mean age of the entire cohort was 59 years old. The median follow-up was 52 months (mean 60, range 24-202). The BR, UC and SP rates were 18.7%, 94.5%, and 71% respectively. Trifecta was achieved in 64% at 2 year follow-up, and 61% at 5 year follow-up. Multivariate analysis revealed age at time of surgery, pathologic Gleason score (PGS), pathologic stage, specimen weight, and nerve sparing (NS) were independent factors. CONCLUSIONS: Age at time of surgery, pathologic GS, pathologic stage, specimen weight and NS were independent predictors to achieve the Trifecta following radical prostatectomy. This information may help patients counseling undergoing radical prostatectomy for localized prostate cancer

    Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer

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    Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3 and FOXA1 as ILC enriched features. PTEN loss associated with increased AKT phosphorylation, which was highest in ILC among all breast cancer subtypes. Spatially clustered FOXA1 mutations correlated with increased FOXA1 expression and activity. Conversely, GATA3 mutations and high expression characterized Luminal A IDC, suggesting differential modulation of ER activity in ILC and IDC. Proliferation and immune-related signatures determined three ILC transcriptional subtypes associated with survival differences. Mixed IDC/ILC cases were molecularly classified as ILC-like and IDC-like revealing no true hybrid features. This multidimensional molecular atlas sheds new light on the genetic bases of ILC and provides potential clinical options

    Southville Revisted

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    Southville Revisited is a quantitative-descriptive study which examined (1) the extent to which Jews in Memphis identify with traditional Jewish values; (2) the effectiveness of current goals and objectives of the Memphis Jewish communal agencies in satisfying the needs of the community; (3) the comparison of the 1979 sample of the population with the respondents in the Southville Survey of 1959; and (4) new directions in planning and in expanding Jewish communal services to meet changing needs evidenced in the current study. In order to accomplish these goals, the researchers utilized approximately 75 percent of the questions derived from the 1959 Southville Survey of Jewish Attitudes. In addition, the researchers added seventeen questions pertaining to the Jewish educational level of the respondents, their views on Israel, and programming for the elderly and Russian immigrants. Sixty-four questions, covering 10 pages, were asked of the respondents in a self-administered questionnaire. Selection of the 1979 sample was based on a systematic random selection of Jewish heads of households. A master list of current heads of households was obtained from the Memphis Jewish Federation from which every thirtieth name was selected. The target population was to represent 3 percent of the Jewish heads of households in Memphis, approximately one hundred persons. The researchers were able to obtain seventy-five completed questionnaires. The process of dissemination and completion of the questionnaires by the sample selected began in the month of October 1978 and was completed in January of 1979. Major findings of the Southville Revisited study included the following: (1) the present sample appears to be an older and more financially and occupationally secure population than the 1959 respondents; (2) the age, income, education, and length of residence of the respondents appears to have a significant influence on the Jewish identity of those questioned; and (3) the importance of Jewish communal agencies (e.g., Jewish Community Center, Jewish Service Agency) indicated by the respondents seems to be offset by the lack of Jewish identification seen in their programming. A lack of Jewish educational background among the 1979 sample was also noticed. Many of the findings of the 1979 sample were seen to be similar to those in the 1959 study in areas such as commitment to Israel. With the knowledge gained from the 1979 sample, a number of program implications became evident. These recommendations included, among others, that communal agencies design programs that appeal to an educated population. These programs should incorporate identifiable Jewish values and customs. Programs related to single parents, separated, divorced, or widowed, should be initiated into the local Jewish community. Programs as well as direct services by the Jewish communal agencies must therefore be positively identified with Jewish values and practices in order to have impact upon the Jewish population in Memphis

    Oncological and functional outcomes following open radical prostatectomy: how patients may achieve the "trifecta"?

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    PURPOSE: The desirable outcomes after open radical prostatectomy (RP) for localized prostate cancer (PC) are to: a) achieve disease recurrence free, b) urinary continence (UC), and c) maintain sexual potency (SP). These 3 combined desirable outcomes we called it the "Trifecta". Our aim is to assess the likelihood of achieving the Trifecta, and to analyze the influencing the Trifecta . MATERIALS AND METHODS: A total of 1738 men with localized PC underwent RP from 1992-2007 by a single surgeon. The exclusion criteria for this analysis were: preoperative hormonal or radiation therapy, preoperative urinary incontinence or erectile dysfunction, follow-up less than 24 months or insufficient data. Post-operative Trifecta factors were analyzed, including biochemical recurrence (BR).. We defined: BR as PSA > 0.2 ng/mL, urinary continence as wearing no pads, and sexual potency as having erections sufficient for intercourse with or without a phosphodiesterase-5 inhibitor. RESULTS: A total of 831 patients met the inclusion criteria. The mean age of the entire cohort was 59 years old. The median follow-up was 52 months (mean 60, range 24-202). The BR, UC and SP rates were 18.7%, 94.5%, and 71% respectively. Trifecta was achieved in 64% at 2 year follow-up, and 61% at 5 year follow-up. Multivariate analysis revealed age at time of surgery, pathologic Gleason score (PGS), pathologic stage, specimen weight, and nerve sparing (NS) were independent factors. CONCLUSIONS: Age at time of surgery, pathologic GS, pathologic stage, specimen weight and NS were independent predictors to achieve the Trifecta following radical prostatectomy. This information may help patients counseling undergoing radical prostatectomy for localized prostate cancer

    Oncological and functional outcomes following open radical prostatectomy: how patients may achieve the "trifecta"?

    No full text
    PURPOSE: The desirable outcomes after open radical prostatectomy (RP) for localized prostate cancer (PC) are to: a) achieve disease recurrence free, b) urinary continence (UC), and c) maintain sexual potency (SP). These 3 combined desirable outcomes we called it the "Trifecta". Our aim is to assess the likelihood of achieving the Trifecta, and to analyze the influencing the Trifecta . MATERIALS AND METHODS: A total of 1738 men with localized PC underwent RP from 1992-2007 by a single surgeon. The exclusion criteria for this analysis were: preoperative hormonal or radiation therapy, preoperative urinary incontinence or erectile dysfunction, follow-up less than 24 months or insufficient data. Post-operative Trifecta factors were analyzed, including biochemical recurrence (BR).. We defined: BR as PSA > 0.2 ng/mL, urinary continence as wearing no pads, and sexual potency as having erections sufficient for intercourse with or without a phosphodiesterase-5 inhibitor. RESULTS: A total of 831 patients met the inclusion criteria. The mean age of the entire cohort was 59 years old. The median follow-up was 52 months (mean 60, range 24-202). The BR, UC and SP rates were 18.7%, 94.5%, and 71% respectively. Trifecta was achieved in 64% at 2 year follow-up, and 61% at 5 year follow-up. Multivariate analysis revealed age at time of surgery, pathologic Gleason score (PGS), pathologic stage, specimen weight, and nerve sparing (NS) were independent factors. CONCLUSIONS: Age at time of surgery, pathologic GS, pathologic stage, specimen weight and NS were independent predictors to achieve the Trifecta following radical prostatectomy. This information may help patients counseling undergoing radical prostatectomy for localized prostate cancer
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