Clinical characteristics. All of the blood sampling was performed under fasting conditions.

<p>* = p<0.05 (antibody negative (insulin± metformin) vs antibody positive (insulin± metformin)).</p><p>**Antibody Positive Group: 6 out of 7 patients were positive for GAD65 Ab. Of those 6 GAD65 Ab positives, 2 were also positive for IA-2 and 3 for ZnT8 Ab. One of these subjects was positive for IA-2 Ab alone. Antibody titer: 3 GAD65 Ab positive 3^rd tertile; 2 IA-2 Ab positive 3^rd tertile.</p><p>Clinical characteristics. All of the blood sampling was performed under fasting conditions.</p

Demographic and immunological characteristics of clinically diagnosed T2DM cadaveric donors captured through the nPOD network.

<p>AA: African American donors, AS: Asian-American donors, CA: Caucasian donors, HI: Hispanic donors.</p><p>Demographic and immunological characteristics of clinically diagnosed T2DM cadaveric donors captured through the nPOD network.</p

Insulin sensitivity in the setting of islet autoimmunity.

<p>Correlation between insulin sensitivity (GIR) and obesity (BMI, central fat) between all antibody negative (n = 11) and antibody positive on insulin±metformin (n = 7). Open squares indicate antibody negative on metformin only while close squares indicate patients on insulin±metformin.</p

Insulin and glucagon immunostaining.

<p>Immunohistochemical staining for insulin (Panel A and C) and glucagon (Panel B and D) in two different islets from different area of the pancreas in a donor with T2DM and pattern A pancreatic pathology. The first islet (panel A and B) contains both insulin and glucagon positive cells, while the second islet (Panel C and D) contains only glucagon positive cells.</p

Beta cell mass determination.

<p>Beta cell mass (expressed as percentage of mean of donors without diabetes mellitus) in T2DM without autoimmune markers [mean 67.70±SEM 13.58 (n = 11) and T2DM with autoimmune markers (mean 12.80±SEM 4.54 (n = 4)] (p = 0.05) Amongst the donors with markers of autoimmune diabetes 4 out of 4 expressed pattern A pathology while among the donors without autoimmune markers, 3 out of 11 expressed pattern B pathology (p = 0.026).</p