Improved estimates for four-year neuropsychological outcomes in children with isolated congenital heart defects.

<p>Abbreviations. SD  =  standard error. ADHD  =  attention deficit/hyperactivity disorder. CBCL  =  Child Behavior Checklist for ages 1.5 to 5 years. PDPs  =  pervasive developmental problems.</p

Baseline and operative characteristics of the cohort.

<p>Abbreviations: SD  =  standard deviation. DHCA  =  deep hypothermic circulatory arrest.</p>a<p><i>APOE</i> genotypes were categorized into three groups: ε2 (ε2ε2, ε2ε3, or ε2ε4), ε3 (ε3ε3), and ε4 (ε3ε4 or ε4ε4).</p

Manhattan plots of –log(<i>P</i>) for association of SNPs and chromosomal position for all SNPs analyzed in linear regression covariate-adjusted models.

<p>Panel A presents the Manhattan plot for the phenotype, ADHD-IV Impulsivity Scale. Panel B presents the Manhattan plot for the phenotype, CBCL/1.5-5 PDPs. Panel C presents the Manhattan plot for the phenotype, CBCL/1.5-5 Total Problems. Red horizontal line represents 5×10⁻⁸ threshold for genome-wide significance. Blue horizontal line indicates the 10⁻⁶ threshold for suggestive genome-wide significance.</p