Incidence of Respiratory Virus-Associated Pneumonia in Urban Poor Young Children of Dhaka, Bangladesh, 2009–2011

Pneumonia is the leading cause of childhood death in Bangladesh. We conducted a longitudinal study to estimate the incidence of virus-associated pneumonia in children aged <2 years in a low-income urban community in Dhaka, Bangladesh.We followed a cohort of children for two years. We collected nasal washes when children presented with respiratory symptoms. Study physicians diagnosed children with cough and age-specific tachypnea and positive lung findings as pneumonia case-patients. We tested respiratory samples for respiratory syncytial virus (RSV), rhinoviruses, human metapneumovirus (HMPV), influenza viruses, human parainfluenza viruses (HPIV 1, 2, 3), and adenoviruses using real-time reverse transcription polymerase chain reaction assays.Between April 2009-March 2011, we followed 515 children for 730 child-years. We identified a total of 378 pneumonia episodes, 77% of the episodes were associated with a respiratory viral pathogen. The overall incidence of pneumonia associated with a respiratory virus infection was 40/100 child-years. The annual incidence of pneumonia/100 child-years associated with a specific respiratory virus in children aged < 2 years was 12.5 for RSV, 6 for rhinoviruses, 6 for HMPV, 4 for influenza viruses, 3 for HPIV and 2 for adenoviruses.Young children in Dhaka are at high risk of childhood pneumonia and the majority of these episodes are associated with viral pathogens. Developing effective low-cost strategies for prevention are a high priority

Real-World Experience with Oritavancin Therapy in Invasive Gram-Positive Infections

<p>Article full text</p> <p>The full text of this article can be found <a href="https://link.springer.com/article/10.1007/s40121-017-0156-z"><b>here</b>.</a></p> <p>Provide enhanced content for this article</p> <p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p> <p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p> <p>Other enhanced features include, but are not limited to:</p> <ul> <li>Slide decks</li> <li>Videos and animations</li> <li>Audio abstracts</li> <li>Audio slides</li> </ul

Frequency of respiratory viral pathogens in episodes of respiratory symptoms (N = 1,322) in a low income urban neighborhood, Dhaka, Bangladesh (April 2009–March 2010).

<p>Frequency of respiratory viral pathogens in episodes of respiratory symptoms (N = 1,322) in a low income urban neighborhood, Dhaka, Bangladesh (April 2009–March 2010).</p

Baseline information of a cohort children (n = 515) in urban low income neighborhood of Dhaka, Bangladesh during April 2009–March 2011.

<p>Baseline information of a cohort children (n = 515) in urban low income neighborhood of Dhaka, Bangladesh during April 2009–March 2011.</p

Monthly distribution of respiratory virus pathogens associated pneumonia in a cohort children in a low income urban neighborhood, Dhaka, Bangladesh (April 2009–March 2011).

<p>Monthly distribution of respiratory virus pathogens associated pneumonia in a cohort children in a low income urban neighborhood, Dhaka, Bangladesh (April 2009–March 2011).</p

Incidence of ARI and pneumonia per 100 child-years associated with different respiratory viral pathogens in a cohort of children aged <2 years in a low income urban neighborhood, Dhaka, Bangladesh (April 2009–March 2011).

<p>Incidence of ARI and pneumonia per 100 child-years associated with different respiratory viral pathogens in a cohort of children aged <2 years in a low income urban neighborhood, Dhaka, Bangladesh (April 2009–March 2011).</p