973 research outputs found
Molecular vibration in cold collision theory
Cold collisions of ground state oxygen molecules with Helium have been
investigated in a wide range of cold collision energies (from 1 K up to 10
K) treating the oxygen molecule first as a rigid rotor and then introducing the
vibrational degree of freedom. The comparison between the two models shows that
at low energies the rigid rotor approximation is very accurate and able to
describe all the dynamical features of the system. The comparison between the
two models has also been extended to cases where the interaction potential He -
O is made artificially stronger. In this case vibration can perturb rate
constants, but fine-tuning the rigid rotor potential can alleviate the
discrepancies between the two models.Comment: 11 pages, 3 figure
Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease
Background
Prostate cancer (PrCa) demonstrates a heterogeneous clinical presentation ranging from largely indolent to lethal. We sought to identify a signature of rare inherited variants that distinguishes between these two extreme phenotypes.
Methods
We sequenced germline whole exomes from 139 aggressive (metastatic, age of diagnosisâ<â60) and 141 non-aggressive (low clinical grade, age of diagnosis â„60) PrCa cases. We conducted rare variant association analyses at gene and gene set levels using SKAT and Bayesian risk index techniques. GO term enrichment analysis was performed for genes with the highest differential burden of rare disruptive variants.
Results
Protein truncating variants (PTVs) in specific DNA repair genes were significantly overrepresented among patients with the aggressive phenotype, with BRCA2, ATM and NBN the most frequently mutated genes. Differential burden of rare variants was identified between metastatic and non-aggressive cases for several genes implicated in angiogenesis, conferring both deleterious and protective effects.
Conclusions
Inherited PTVs in several DNA repair genes distinguish aggressive from non-aggressive PrCa cases. Furthermore, inherited variants in genes with roles in angiogenesis may be potential predictors for risk of metastases. If validated in a larger dataset, these findings have potential for future clinical application
Entropic Uncertainty Relations in Quantum Physics
Uncertainty relations have become the trademark of quantum theory since they
were formulated by Bohr and Heisenberg. This review covers various
generalizations and extensions of the uncertainty relations in quantum theory
that involve the R\'enyi and the Shannon entropies. The advantages of these
entropic uncertainty relations are pointed out and their more direct connection
to the observed phenomena is emphasized. Several remaining open problems are
mentionedComment: 35 pages, review pape
An AzTEC 1.1-mm survey for ULIRGs in the field of the Galaxy Cluster MS 0451.6â0305
This article has been accepted for publication in Monthly Notices Of The Royal Astronomical Society ©: 2010 J. L. Wardlow et al. Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved.We have undertaken a deep (Ï⌠1.1 mJy) 1.1-mm survey of the z= 0.54 cluster MS 0451.6â0305 using the AzTEC camera on the James Clerk Maxwell Telescope. We detect 36 sources with signal-to-noise ratio (S/N) â„ 3.5 in the central 0.10 deg2 and present the AzTEC map, catalogue and number counts. We identify counterparts to 18 sources (50 per cent) using radio, mid-infrared, Spitzer InfraRed Array Camera (IRAC) and Submillimetre Array data. Optical, near- and mid-infrared spectral energy distributions are compiled for the 14 of these galaxies with detectable counterparts, which are expected to contain all likely cluster members. We then use photometric redshifts and colour selection to separate background galaxies from potential cluster members and test the reliability of this technique using archival observations of submillimetre galaxies. We find two potential MS 0451â03 members, which, if they are both cluster galaxies, have a total star formation rate (SFR) of âŒ100 Mâ yrâ1â a significant fraction of the combined SFR of all the other galaxies in MS 0451â03. We also examine the stacked rest-frame mid-infrared, millimetre and radio emission of cluster members below our AzTEC detection limit, and find that the SFRs of mid-IR-selected galaxies in the cluster and redshift-matched field populations are comparable. In contrast, the average SFR of the morphologically classified late-type cluster population is nearly three times less than the corresponding redshift-matched field galaxies. This suggests that these galaxies may be in the process of being transformed on the red sequence by the cluster environment. Our survey demonstrates that although the environment of MS 0451â03 appears to suppress star formation in late-type galaxies, it can support active, dust-obscured mid-IR galaxies and potentially millimetre-detected LIRGs
AzTEC/ASTE 1.1-mm survey of SSA22: Counterpart identification and photometric redshift survey of submillimetre galaxies
This article has been accepted for publication in Monthly Notices Of The Royal Astronomical Society ©: 2014 H. Umehata et al. Published by Oxford University Press on behalf of the Royal Astronomical Society. All rights reserved.We present the results from a 1.1-mm imaging survey of the SSA22 field, known for having an overdensity of z = 3.1 Lyman α emitting galaxies (LAEs), taken with the astronomical thermal emission camera (AzTEC) on the Atacama Submillimeter Telescope Experiment (ASTE). We imaged a 950-arcmin^(2) field down to a 1Ï sensitivity of 0.7â1.3 mJy beam^(â1) to find 125 submillimetre galaxies (SMGs) with a signal-to-noise ratio â„3.5. Counterpart identification using radio and near/mid-infrared data was performed and one or more counterpart candidates were found for 59 SMGs. Photometric redshifts based on optical to near-infrared images were evaluated for 45 of these SMGs with Spitzer/IRAC data and the median value is found to be z = 2.4. By combining these estimations with estimates from the literature, we determined that 10 SMGs might lie within the large-scale structure at z = 3.1. The two-point angular cross-correlation function between LAEs and SMGs indicates that the positions of the SMGs are correlated with the z = 3.1 protocluster. These results suggest that the SMGs were formed and evolved selectively in the high dense environment of the high-redshift Universe. This picture is consistent with the predictions of the standard model of hierarchical structure formation
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