52 research outputs found
Synthesis and pharmacological activity of 4-carbamoyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones
Get PDFA new series of 4-carbamoyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones 4a-g have been synthesized and tested for their anti-inflammatory and analgesic properties. Among the tested compounds, only 4f at 1 mmole/Kg showed antiinflammatory activity that was comparable with that of indomethacin (5 mg/Kg) though of shorter duration. Compounds 4a, 4e and especially 4g at 0.2 mmoles/Kg displayed relevant analgesic activity, 4g being the most potent derivative in the writhing test. Compounds 4c and 4g were found to possess analgesic activity also in the hot plate test
ChemInform Abstract: HYDROXYMETHYLATION OF PROPIOPHENONES IN AQUEOUS MEDIUM: A NEW ROUTE TO 1-ARYL-2-METHYL-2-PROPEN-1-ONES
No full textChemInform Abstract: A Facile Synthesis of 3-Aryl-4-pyrazoleacetic Acids and of Their 4,5-Dihydro Derivatives.
No full textHydroxymethylation of 2-hydroxypropiophenones in aqueous medium. Synthesis of 3-hydroxymethyl-3-methyl-4-chromanones and their conversion to 3-methyl-4-chromanone-3-acetic acids
No full textReinvestigation of the reaction of 3-hydroxy-2-methyl-1-aryl-propanones and related compounds with hydrazines and carboxylic acids
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Reaction of 4-aroyl-2(3H)dihydrofuranones with hydroxylamine hydrochloride. Synthesis and pharmacological study of a series of 3-aryl-4,5-dihydro-4-isoxazoleacetic acids
No full textA facile synthesis of 3-aryl-4-pyrazole acetic acids and of their 4,5-dihydro derivatives
No full textAntihypertensive and antithrombotic activities of 6-(substitutedphenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones
No full textThe synthesis of a series of 6-(4R-phenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones is reported. The compounds were evaluated for their oral antihypertensive activity in rats and some of them [(V b), R = NH2] and [(V c), R = NHCOCH3] were found to induce a high decrease in systolic blood pressure. Moreover all the compounds displayed an antithrombotic activity comparable to, or greater than, that of ASA
A new heterocyclic class: 2,5,6-trisubstituted-6,7-dihydro-1,3,4-oxadiazepines: A facile and general synthesis
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