Gauge covariance and the fermion-photon vertex in three- and four- dimensional, massless quantum electrodynamics

In the quenched approximation, the gauge covariance properties of three vertex Ans\"{a}tze in the Schwinger-Dyson equation for the fermion self energy are analysed in three- and four- dimensional quantum electrodynamics. Based on the Cornwall-Jackiw-Tomboulis effective action, it is inferred that the spectral representation used for the vertex in the gauge technique cannot support dynamical chiral symmetry breaking. A criterion for establishing whether a given Ansatz can confer gauge covariance upon the Schwinger-Dyson equation is presented and the Curtis and Pennington Ansatz is shown to satisfy this constraint. We obtain an analytic solution of the Schwinger-Dyson equation for quenched, massless three-dimensional quantum electrodynamics for arbitrary values of the gauge parameter in the absence of dynamical chiral symmetry breaking.Comment: 17 pages, PHY-7143-TH-93, REVTE

Permanent-magnet atom chips for the study of long, thin atom clouds

Atom-chip technology can be used to confine atoms tightly using permanently magnetised videotape along with external magnetic fields. The one-dimensional (1D) gas regime can be realised and studied by trapping the atoms in high-aspect-ratio traps in which the radial motion of the system is confined to zero-point oscillation

Study of Regions of Extended Homozygosity Provides a Powerful Method to Explore Haplotype Structure of Human Populations

Previous investigations have reported linkage disequilibrium occurring between nearby polymorphisms, a block-like structure for such relationships, some instances where surprisingly few haplotypes are found and regions of extended homozygosity which are especially marked around centromeres and which are especially common on the X chromosome. We investigated the distribution and nature of regions of extended homozygosity in a sample of 1411 subjects included in a genome wide association study. Regions of extended homozygosity over 1Mb are common, with an average of 35.9 occurring per subject, and containing on average 73 homozygous markers. They have a markedly non-random distribution. They are relatively common on the X chromosome and are seen at centromeres but are also concentrated at other chromosomal regions where presumably recombination is rare. They seem to be a consequence of some haplotypes being very common in the population and although sometimes this reflects the effect of a very common haplotype we also note that there are examples of two or three common haplotypes, each very different from each other, underlying this effect. Regions of extended homozygosity are commoner than previously appreciated. They result from the presence of extended haplotypes with high population frequency. Such regions concentrate in particular locations. The haplotypes involved are sometimes markedly disparate from each other. These regions offer a valuable opportunity for further investigation, in particular with regard to their ancestral history

Investigation into the Ability of SNP Chipsets and Microsatellites to Detect Association with a Disease Locus

We wished to investigate the ability of different SNP chipsets to detect association with a disease and to investigate the linkage disequilibrium (LD) relationships between microsatellites and nearby SNPs in order to assess their potential usefulness to detect association

Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs

Rocaglamide has been reported to sensitize several cell types to TRAIL-induced apoptosis. In recent years, advances in synthetic techniques have led to generation of novel rocaglamide analogs. However, these have not been extensively analyzed as TRAIL sensitizers, particularly in TRAIL-resistant renal cell carcinoma cells. Evaluation of rocaglamide and analogs identified 29 compounds that are able to sensitize TRAIL-resistant ACHN cells to TRAIL-induced, caspase-dependent apoptosis with sub-µM potency which correlated with their potency as protein synthesis inhibitors and with loss of cFLIP protein in the same cells. Rocaglamide alone induced cell cycle arrest, but not apoptosis. Rocaglates averaged 4–5-fold higher potency as TRAIL sensitizers than as protein synthesis inhibitors suggesting a potential window for maximizing TRAIL sensitization while minimizing effects of general protein synthesis inhibition. A wide range of other rocaglate effects (e.g. on JNK or RAF-MEK-ERK signaling, death receptor levels, ROS, ER stress, eIF4E phosphorylation) were assessed, but did not contribute to TRAIL sensitization. Other than a rapid loss of MCL-1, rocaglates had minimal effects on mitochondrial apoptotic pathway proteins. The identification of structurally diverse/mechanistically similar TRAIL sensitizing rocaglates provides insights into both rocaglate structure and function and potential further development for use in RCC-directed combination therapy.This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported [in part] by the Intramural Research Program of NIH, Frederick. National Lab, Center for Cancer Research. Research performed at Boston University was supported in part by NIH R35 GM118173. Work at the BU-CMD is supported by R24 GM111625. (HHSN261200800001E - National Cancer Institute, National Institutes of Health; Intramural Research Program of NIH, Frederick. National Lab, Center for Cancer Research; R35 GM118173 - NIH; R24 GM111625)Published versio

A Serendipitous Search for High-Redshift Lyman alpha Emission: Two Primeval Galaxy Candidates at z~3

In the course of our ongoing search for serendipitous high-redshift Lyman alpha (LyA) Emissionin deep archival Keck spectra, we discovered two very high equivalent width (W_{obs} ~ 450A, 2-sigma) LyA emission line candidates at z ~3 in a moderate dispersion (R~1200) spectrogram. Both lines have low velocity dispersions (sigma_v ~ 60 km/s) and deconvolved radii r ~ 1 kpc (h = 0.5). We argue that the lines are LyA, and are powered by stellar ionization. The surface density of robust, high equivalent width LyA candidates is estimated to be ~3 \pm 2 per arcmin^2 per unit redshift at z ~ 3, consistent with the estimate of Cowie etal (1998). The LyA emission line source characteristics are consistent with the galaxies undergoing their first burst of star formation, ie, with being primeval. Source sizes and velocity dispersions are comparable to the theoretical primeval galaxy model of Lin and Murray (1992) based on the inside-out, self-similar collapse of an isothermal sphere. In this model, star formation among field galaxies is a protracted process. Galaxies are thought to be able to display high equivalent widths for only the first few x 10 Myr. This time is short in relation to the difference in look back times between z=3 and z=4, and implies that a substantial fraction of strong line-emitting galaxies at z=3 were formed at redshifts z < 4. We discuss the significance of high-equivalent width LyA-emitting galaxies in terms of the emerging picture of the environment, and the specific characteristics of primeval galaxy formation at high redshift.Comment: 17 pages, 3 figures, one table. To appear in the Astrophysical Journa

The Lightest Pseudo-Goldstone Boson at Future e+e- Colliders

In a class of models of dynamical symmetry breaking not ruled out by the available data, the lightest neutral pseudo-Nambu-Goldstone boson P0 contains only down-type techniquarks and charged technileptons. Its mass scale is naturally determined by the b-quark and therefore it is likely to be light. As the presence of pseudo-Nambu-Goldstone bosons in models of dynamical symmetry breaking is a quite general feature, the search of the P0 at colliders is an interesting opportunity of putting limits on or discovering a dynamical electroweak symmetry breaking scenario. In this note we discuss the prospects for discovering and studying the P0 at future e+e- and gamma-gamma colliders.Comment: 15 pages, 8 figures, LaTeX (epsfig), Proceedings of the Second ECFA/DESY Study on Physics Studies for a Future Linear Collide

Bose-Einstein Condensation on a Permanent-Magnet Atom Chip

We have produced a Bose-Einstein condensate on a permanent-magnet atom chip based on periodically magnetized videotape. We observe the expansion and dynamics of the condensate in one of the microscopic waveguides close to the surface. The lifetime for atoms to remain trapped near this dielectric material is significantly longer than above a metal surface of the same thickness. These results illustrate the suitability of microscopic permanent-magnet structures for quantum-coherent preparation and manipulation of cold atoms.Comment: 4 pages, 6 figures, Published in Phys. Rev. A, Rapid Com

Bose-Einstein Condensation on a Permanent-Magnet Atom Chip

We have produced a Bose-Einstein condensate on a permanent-magnet atom chip based on periodically magnetized videotape. We observe the expansion and dynamics of the condensate in one of the microscopic waveguides close to the surface. The lifetime for atoms to remain trapped near this dielectric material is significantly longer than above a metal surface of the same thickness. These results illustrate the suitability of microscopic permanent-magnet structures for quantum-coherent preparation and manipulation of cold atoms.Comment: 4 pages, 6 figures, Published in Phys. Rev. A, Rapid Com