A Necropolitical Analysis of American Military Recruitment

In light of postcolonial theorist Achille Mbembe’s idea of necropolitics or sovereignty’s right to kill, Curtin historically and ethically analyzes American military recruitment from a draft to an all-volunteer-force. Defining soldiering as a form of necropolitical labor because soldiers, especially low-ranked soldiers, jeopardize their own lives while carrying out their jobs at war, the author ethically suggests that (1) war must be understood as a path to death, (2) the U.S. should slowly downsize its military, and (3) religion such as Christianity must accentuate life over death

Chance the Rapper and Moltmann\u27s Theology of Hope, from Chance the Rapper as Chicago\u27s Prophet: An Intersection of Rap, Religion, and Race

This project is an investigation of Chance the Rapper, both as a person and a musician. The focus is his most recent activism within his non-profit, Social Works, and his most recent mixtape, Coloring Book. Both his activism and music are executed with a biblical message and Chance’s unapologetic identity as a Christian. Between his music and activism, Chance has become a very popular figure in a way that surpasses mere celebrity. His music is religious–it is heavily mixed with gospel music and celebrates God, blessings, and angels–but is coupled with activism that authentically supports his Christian message. This project is a multi-lens investigation on the four interlocking roles Chance occupies: Chance as Christian, activist, musician, and Black Chicagoan. The majority of Chance’s activism is targeted towards South Side Chicago, both his hometown and a majority Black, notoriously violent part of the country. This project analyzes the effect that his leadership and music has locally and internationally through different lenses. Using literature on race, Chicago’s racial history, theology, and cultural studies, I investigate the ways in which Chance, as a figure, impacts and engages culture in radical and meaningful ways. These different lenses allow for a creative comparative analysis. Sarah Curtin \u2718 is from Chicago, IL and received her BA in Religion and English Literature from Denison University

Embodied Ayurveda

“Embodied Ayurveda” by Sarah Curtin, ’18. The author focuses on traditional, modern, and global iterations of the traditional Indian medical system Ayurveda. Whereas Western medicine focuses on empiricism, results, and relatively stringent proof of efficacy, traditional Ayurveda holds ancient texts in high regard, separating body functions and processes into pure and impure categories that have little basis in the Western medicinal tradition. However, as pharmaceutical companies latch on to the increasing popularity of traditional Indian medicine, the integrity, practice, and plant-based sources for Ayurvedic remedies are all threatened. Curtin continues to discuss traditional notions of semen conservation versus the modernized notion of semen conservation as a manner of preserving masculinity as many pharmaceutical companies market it. Finally, Curtin discusses globalized Ayurvedic trends and their ethical implications for traditional practices

Novel Gene Therapeutic Approaches to Brain Cancer

In the United States, approximately 17,000 people per year are diagnosed with brain tumors, the leading cause of death from cancers in children ages 1-15 year (1,2). Gliomas are the most prevalent type of brain tumors in adults, affecting 3.2/100,000 persons/yr in the United States (www.CBTRUS.org). In spite of advances in surgery, chemotherapy, and radiotherapy, the mean survival time of patients post-diagnosis remains approximately 9-12 months

Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition

ATR is an attractive target in cancer therapy because it signals replication stress and DNA lesions for repair and to S/G2 checkpoints. Cancer-specific defects in the DNA damage response (DDR) may render cancer cells vulnerable to ATR inhibition alone. We determined the cytotoxicity of the ATR inhibitor VE-821 in isogenically matched cells with DDR imbalance. Cell cycle arrest, DNA damage accumulation and repair were determined following VE-821 exposure. Defects in homologous recombination repair (HRR: ATM, BRCA2 and XRCC3) and base excision repair (BER: XRCC1) conferred sensitivity to VE-821. Surprisingly, the loss of different components of the trimeric non-homologous end-joining (NHEJ) protein DNA-PK had opposing effects. Loss of the DNA-binding component, Ku80, caused hypersensitivity to VE-821, but loss of its partner catalytic subunit, DNA-PKcs, did not. Unexpectedly, VE-821 was particularly cytotoxic to human and hamster cells expressing high levels of DNA-PKcs. High DNA-PKcs was associated with replicative stress and activation of the DDR. VE-821 suppressed HRR, determined by RAD51 focus formation, to a greater extent in cells with high DNA-PKcs. Defects in HRR and BER and high DNA-PKcs expression, that are common in cancer, confer sensitivity to ATR inhibitor monotherapy and may be developed as predictive biomarkers for personalised medicine

The prevalence of obesity in children with autism: a secondary data analysis using nationally representative data from the National Survey of Children's Health

<p>Abstract</p> <p>Background</p> <p>The prevalence of childhood obesity has increased dramatically in the last two decades and numerous efforts to understand, intervene on, and prevent this significant threat to children's health are underway for many segments of the pediatric population. Understanding the prevalence of obesity in populations of children with developmental disorders is an important undertaking, as the factors that give rise to obesity may not be the same as for typically developing children, and because prevention and treatment efforts may need to be tailored to meet their needs and the needs of their families. The goal of the current study was to estimate the prevalence of obesity in children and adolescents with autism.</p> <p>Methods</p> <p>This study was a secondary data analysis of cross-sectional nationally representative data collected by telephone interview of parents/guardians on 85,272 children ages 3-17 from the 2003-2004 National Survey of Children's Health (NSCH). Autism was determined by response to the question, "Has a doctor or health professional ever told you that your child has autism?" Children and adolescents were classified as obese accordingto CDC guidelines for body mass index (BMI) for age and sex.</p> <p>Results</p> <p>The prevalence of obesity in children with autism was 30.4% compared to 23.6% of children without autism (p = .075). The unadjusted odds of obesity in children with autism was 1.42 (95% confidence interval (CI): 1.00, 2.02, p = .052) compared to children without autism.</p> <p>Conclusions</p> <p>Based on US nationally representative data, children with autism have a prevalence of obesity at least as high as children overall. These findings suggest that additional research is warranted to understand better the factors that influence the development of obesity in this population of children.</p