Farming or Foraging?: Household Labour and Livelihood Strategies amongst Smallholder Cocoa Growers in Papua New Guinea

Drawing on household level studies of cocoa production amongst village communities in Papua New Guinea’s Gazelle Peninsula, Farming or Foraging? presents a socio-economic and cultural model of smallholder productivity. The book discusses how commercial sector organisations can be drawn upon to provide smallholder extension strategies that are better integrated with the livelihoods of village producers. This book will be of value to researchers and agricultural extension organisations working with smallholders in developing countries across a range of different cash crops

A bridge too far? The influence of socio-cultural values on the adaptation responses of smallholders to a devastating pest outbreak in cocoa

The influence of socio-cultural factors on the adaptive capacity, resilience and trade-offs in decision-making of households and communities is receiving growing scholarly attention. In many partly transformed societies, where the market economy is not well developed, livelihood practices are heavily structured by kinship and indigenous social and economic values. Farm investment decisions and incentives to produce agricultural commodities are shaped by a host of considerations in addition to market imperatives like profit. In one such partly transformed society in East New Britain Province, Papua New Guinea, we examine the adaptation decisions of smallholders in response to the drastic drop of yield in their cocoa plots caused by the sudden outbreak of Cocoa Pod Borer. To explain why the impact of the pest has been so great we examine the interconnections between household responses, the local socio-cultural and economic context of smallholder commodity crop production and the wider institutional environment in which household choices and decisions are made. We argue that the significant lifestyle changes and labour intensive farming methods required for the effective control of Cocoa Pod Borer are incompatible with existing smallholder farming systems, values and livelihoods. To adopt a high input cropping system requires more than a technical fix and some training; it also requires abandoning a 'way of life' that provides status, identity and a moral order, and which is therefore highly resistant to change. The paper highlights the enduring influence and significance of local, culturally-specific beliefs and socio-economic values and their influence on how individuals and communities make adaptation decisions

The use of activity diaries for understanding the daily lives of farmers and their livelihood choices

This paper reviews the use of activity diaries in two Australian Centre for International Agricultural Research (ACIAR) projects in PNG: a smallholder cocoa project in the East New Britain province (ASEM/2006/127) and a smallholder coffee project in Eastern Highlands province (ASEM/2008/036). Both projects were similarly concerned with identifying the production constraints on cocoa- and coffee-farming households and to better understand the range of socioeconomic and cultural factors influencing farmer decision-making and the allocation of household labour among various livelihood activities. In PNG, the household is the principal production unit underpinning livelihood activities such as commodity production. It is at the household level that decisions and negotiations are made regarding the organisation, mobilisation and management of family and extended family labour. Thus, examining in detail the daily economic and social livelihood activities of household members, through time-allocation studies, helps researchers to understand more comprehensively the factors influencing smallholder decision-making regarding livelihood choices, agricultural practices and the adoption of agricultural innovations. This paper outlines two different techniques using activity diaries employed in the projects, and discusses the methodological advantages and challenges of these techniques in smallholder studies in PNG

A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation

Background: Nasopharyngeal carcinoma (NPC) is an epithelial malignancy strongly associated with Epstein-Barr virus (EBV). AT13387 is a novel heat shock protein 90 (Hsp90) inhibitor, which inhibits the chaperone function of Hsp90 and reduces expression of Hsp90-dependent client oncoproteins. This study aimed to evaluate both the in vitro and in vivo antitumor effects of AT13387 in the EBV-positive NPC cell line C666-1.Results: Our results showed that AT13387 inhibited C666-1 cell growth and induced cellular senescence with the downregulation of multiple Hsp90 client oncoproteins EGFR, AKT, CDK4, and restored the protein expression of negative cell cycle regulator p27. We also studied the ability of AT13387 to restore p27 expression by downregulation of AKT and the p27 ubiquitin mediator, Skp2, using AKT inhibitor and Skp2 siRNA. In the functional study, AT13387 inhibited cell migration with downregulation of a cell migration regulator, HDAC6, and increased the acetylation and stabilization of α-tubulin. We also examined the effect of AT13387 on putative cancer stem cells (CSC) by 3-D tumor sphere formation assay. AT13387 effectively reduced both the number and size of C666-1 tumor spheres with decreased expression of NPC CSC-like markers CD44 and SOX2. In the in vivo study, AT13387 significantly suppressed tumor formation in C666-1 NPC xenografts.Conclusion: AT13387 suppressed cell growth, cell migration, tumor sphere formation and induced cellular senescence on EBV-positive NPC cell line C666-1. Also, the antitumor effect of AT13387 was demonstrated in an in vivo model. This study provided experimental evidence for the preclinical value of using AT13387 as an effective antitumor agent in treatment of NPC. © 2013 Chan et al.; licensee BioMed Central Ltd.published_or_final_versio

Solid variant of aneurysmal bone cyst of the thoracic spine: a case report

<p>Abstract</p> <p>Introduction</p> <p>The solid variant of aneurysmal bone cyst is rare, and only 13 cases involving the spine have been reported to date, including seven in the thoracic vertebrae. The diagnosis is difficult to secure radiographically before biopsy or surgery.</p> <p>Case report</p> <p>An 18-year-old Hispanic man presented to our facility with a one-year history of left chest pain without any significant neurological deficits. An MRI scan demonstrated a 6 cm diameter enhancing multi-cystic mass centered at the T6 vertebral body with involvement of the left proximal sixth rib and extension into the pleural cavity; the spinal cord was severely compressed with evidence of abnormal T2 signal changes. Our patient was taken to the operating room for a total spondylectomy of T6 with resection of the left sixth rib from a single-stage posterior-only approach. The vertebral column was reconstructed in a 360° manner with an expandable titanium cage and pedicle screw fixation. Histologically, the resected specimen showed predominant solid fibroblastic proliferation, with minor foci of reactive osteoid formation, an area of osteoclastic-like giant cells, and cyst-like areas filled with erythrocytes and focal hemorrhage, consistent with a predominantly solid variant of aneurysmal bone cyst. At 16 months after surgery, our patient remains neurologically intact with resolution of his chest and back pain.</p> <p>Conclusions</p> <p>Because of its rarity, location, and radical treatment approach, we considered this case worthy of reporting. The solid variant of aneurysmal bone cyst is difficult to diagnose radiologically before biopsy or surgery, and we hope to remind other physicians that it should be included in the differential diagnosis of any lytic expansile destructive lesion of the spine.</p

Autonomous and Lagrangian ocean observations for Atlantic tropical cyclone studies and forecasts

Author Posting. © The Oceanography Society, 2017. This article is posted here by permission of The Oceanography Society for personal use, not for redistribution. The definitive version was published in Oceanography 30, no. 2 (2017): 92–103, doi:10.5670/oceanog.2017.227.The tropical Atlantic basin is one of seven global regions where tropical cyclones (TCs) commonly originate, intensify, and affect highly populated coastal areas. Under appropriate atmospheric conditions, TC intensification can be linked to upper-ocean properties. Errors in Atlantic TC intensification forecasts have not been significantly reduced during the last 25 years. The combined use of in situ and satellite observations, particularly of temperature and salinity ahead of TCs, has the potential to improve the representation of the ocean, more accurately initialize hurricane intensity forecast models, and identify areas where TCs may intensify. However, a sustained in situ ocean observing system in the tropical North Atlantic Ocean and Caribbean Sea dedicated to measuring subsurface temperature, salinity, and density fields in support of TC intensity studies and forecasts has yet to be designed and implemented. Autonomous and Lagrangian platforms and sensors offer cost-effective opportunities to accomplish this objective. Here, we highlight recent efforts to use autonomous platforms and sensors, including surface drifters, profiling floats, underwater gliders, and dropsondes, to better understand air-sea processes during high-wind events, particularly those geared toward improving hurricane intensity forecasts. Real-time data availability is key for assimilation into numerical weather forecast models.The NOAA/AOML component of this work was originally funded by the Disaster Relief Appropriations Act of 2013, also known as the Sandy Supplemental, and is currently funded through NOAA research grant NA14OAR4830103 by AOML and CARICOOS, as well as NOAA’s Integrated Ocean Observing System (IOOS). The TEMPESTS component of this work is supported by NOAA through the Cooperative Institute for the North Atlantic Region (NA13OAR4830233) with additional analysis support from the WHOI Summer Student Fellowship Program, Nortek Student Equipment Grant, and the Rutgers University Teledyne Webb Graduate Student Fellowship Program. The drifter component of this work is funded through NOAA grant NA15OAR4320071(11.432) in support of the Global Drifter Program