12 research outputs found
Genetic variability of 10 microsatellite markers in the characterization of Brazilian Nellore cattle (Bos indicus)
Identification of a major gene (Mex-1) from Coffea canephora conferring resistance to Meloidogyne exigua in Coffea arabica
Blunt abdominal trauma with small bowel injury: are isolated lesions riskier than associated lesions?
Impact of age and body mass on the intensity of menopausal symptoms in 5968 Brazilian women
Beneficial effects of Heqi san on rat model of polycystic ovary syndrome through the PI3K/AKT pathway
Establishing the natural history and growth rate of ameloblastoma with implications for management: systematic review and meta-analysis
Background: Ameloblastoma is the second most common odontogenic tumor, known to be slow-growing, persistent, and locally aggressive. Recent data suggests that ameloblastoma is best treated with wide resection and adequate margins. Following primary excision, bony reconstruction is often necessary for a functional and aesthetically satisfactory outcome, making early diagnosis paramount. Despite earlier diagnosis potentially limiting the extent of resection and reconstruction, an understanding of the growth rate and natural history of ameloblastoma has been notably lacking from the literature.\ud
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Method: A systematic review of the literature was conducted by reviewing relevant articles from PubMed and Web of Science databases. Each article's level of evidence was formally appraised according to the Centre of Evidence Based Medicine (CEBM), with data from each utilized in a meta-analysis of growth rates for ameloblastoma.\ud
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Results: Literature regarding the natural history of ameloblastoma is limited since the tumor is immediately acted upon at its initial detection, unless the patient voluntarily refuses a surgical intervention. From the limited data, it is derived that the highest estimated growth rate is associated with solid, multicystic type and the lowest rate with peripheral ameloblastomas. After meta-analysis, the calculated mean specific grow rate is 87.84% per year.\ud
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Conclusion: The growth rate of ameloblastoma has been demonstrated, offering prognostic and management information, particularly in cases where a delay in management is envisaged