Dynamic acoustic field activated cell separation (DAFACS)

Advances in diagnostics, cell and stem cell technologies drive the development of application-specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for highthroughput, label-free, high recovery, cell and particle separation and isolation in regenerative medicine. Here, we demonstrate a novel approach utilizing a dynamic acoustic field that is capable of separating an arbitrary size range of cells. We first demonstrate the method for the separation of particles with different diameters between 6 and 45 μm and secondly particles of different densities in a heterogeneous medium. The dynamic acoustic field is then used to separate dorsal root ganglion cells. The shearless, label-free and low damage characteristics make this method of manipulation particularly suited for biological applications. Advantages of using a dynamic acoustic field for the separation of cells include its inherent safety and biocompatibility, the possibility to operate over large distances (centimetres), high purity (ratio of particle population, up to 100%), and high efficiency (ratio of separated particles over total number of particles to separate, up to 100%)

Comparing Ecosystem Service preferences between urban and rural dwellers

Urbanization can profoundly alter socioecological relationships, but its influence on how people perceive and value ecosystem services (ES) is poorly understood. We reviewed an emerging literature in which sociocultural valuation of ES is compared among urban and rural dwellers. This research suggests that, although regulating and cultural ES were highly valued by both rural and urban dwellers, urban dwellers tended to value provisioning ES less than rural dwellers did. Differences in ES valuation could result from different experiences, uses, and needs for ES of urban and rural dwellers. We also identified two key gaps in the literature that relate to understanding how diverse ES contribute differently to the well-being of rural and urban populations (and the relevance of these differences for environmental education and policy) and the changing roles of ES in developing countries and vulnerable ecosystems, such as small islands, that face pressing environmental, social, and economic challenges

Relinquishing Control: What Romanian De Se Attitude Reports Teach Us About Immunity To Error Through Misidentification

Higginbotham argued that certain linguistic items of English, when used in indirect discourse, necessarily trigger first-personal interpretations. They are: the emphatic reflexive pronoun and the controlled understood subject, represented as PRO. PRO is special, in this respect, due to its imposing obligatory control effects between the main clause and its subordinates ). Folescu & Higginbotham, in addition, argued that in Romanian, a language whose grammar doesn’t assign a prominent role to PRO, de se triggers are correlated with the subjunctive mood of certain verbs. That paper, however, didn’t account for the grammatical diversity of the reports that display immunity to error through misidentification in Romanian: some of these reports are expressed by using de se triggers; others are not. Their IEM, moreover, is not systematically lexically controlled by the verbs, via their theta-roles; it is, rather, determined by the meaning of the verbs in question. Given the data from Romanian, I will argue, the phenomenon of IEM cannot be fully explained starting either from the syntactical or the lexical structure of a language

The influence of landscape context on the production of cultural ecosystem services

Recent efforts to apply sustainability concepts to entire landscapes have seen increasing interest in approaches that connect socioeconomic and biophysical systems. Evaluating these connections through a cultural ecosystem services lens clarifies how different spatiotemporal scales and levels of organisation influence the production of cultural benefits. Currently, however, the effects of multi-level and multi-scale ecological variation on the production of cultural benefits have not yet been disentangled. Objectives To quantify the amount of variation in cultural ecosystem service provision by birds to birders that is due to landscape-level attributes. Methods We used data from 293 birding routes and 101 different birders in South African National Parks to explore the general relationships between birder responses to bird species and environmental conditions, bird-related observations, the biophysical attributes of the landscape and their effect on bird-related cultural benefits. Results Biophysical attributes (particularly biome, vegetation type, and variance in elevation) significantly increased the percentage of variance explained in birder benefits from 57 to 65%, demonstrating that birder benefits are derived from multi-level (birds to ecosystems) and multi-scale (site to landscape) social and ecological interactions. Conclusions Landscape attributes influence people's perceptions of cultural ecosystem service provision by individual species. Recognition of the complex, localised and inextricable linkage of cultural ecosystem services to biophysical attributes can improve our understanding of the landscape characteristics that affect the supply and demand of cultural ecosystem services

Silicon mirror suspensions for gravitational wave detectors

One of the most significant limits to the sensitivity of current, and future, long-baseline interferometric gravitational wave detectors is thermal displacement noise of the test masses and their suspensions. This paper reports results of analytical and experimental studies of the limits to thermal noise performance of cryogenic silicon test mass suspensions set by two constraints on suspension fibre dimensions: the minimum dimensions required to allow conductive cooling for extracting incident laser beam heat deposited in the mirrors; and the minimum dimensions of fibres (set by their tensile strength) which can support test masses of the size envisaged for use in future detectors. We report experimental studies of breaking strength of silicon ribbons, and resulting design implications for the feasibility of suspension designs for future gravitational wave detectors using silicon suspension fibres. We analyse the implication of this study for thermal noise performance of cryogenically cooled silicon suspensions

Micro-cooler Enhancements by Barrier Interface Analysis

Peer reviewedPublisher PD

The first Suzaku observation of SGR 1806-20

The soft gamma-ray repeater SGR 1806-20 has been attracting a lot of attention owing to the fact that in December 2004 it emitted the most powerful giant flare ever observed. Here we present the results of the first Suzaku observation of SGR 1806-20, that seems to have reached a state characterized by a flux close to the pre-flare level and by a relatively soft spectrum. Despite this, the source remained quite active, as testified by several short bursts observed by Suzaku. We discuss the broadband spectral properties of SGR 1806-20 in the context of the magnetar model, considering its recent theoretical developments.Comment: 3 pages, 1 figure. Proceedings of the conference "40 Years of Pulsars, Millisecond Pulsars, Magnetars and More", Montreal, August 12-17 2007. AIP, in pres

The role of socio-demographic characteristics in mediating relationships between people and nature

Research on ecosystem services has focused on their availability or supply and often takes a socially-aggregated approach that assumes a single human community of identical beneficiaries. However, people's ability to derive benefits from ecosystem services can differ strongly across societal groups. Access to ecosystem services can be related to socio-demographic characteristics such as material wealth, gender, education and age. Developing environmental management that does not have unequal impacts on different groups thus depends on taking a socially-disaggregated approach to assessing perceptions of ecosystem services. We explored how socio-demographic characteristics relate to cultural functional groups based on perceived bird traits. Using perception data on 491 bird species from 401 respondents along urban-rural gradients in South Africa, we found that socio-demographic characteristics are strongly associated with cultural functional groups based on perceived bird traits. Our results provide a starting point for understanding heterogeneity in the benefits from avian ecosystem services and how perceptions of cultural functional groups vary across societal groups

Mitigation of Moral Hazard and Adverse Selection in Venture Capital Financing: The Influence of the Country’s Institutional Setting

A venture capitalist (VC) needs to trade off benefits and costs when attempting to mitigate agency problems in their investor-investee relationship. We argue that signals of ventures complement the VC’s capacity to screen and conduct a due diligence during the pre-investment phase, but its attractiveness may diminish in institutional settings supporting greater transparency. Similarly, whereas a VC may opt for contractual covenants to curb potential opportunism by ventures in the post-investment phase, this may only be effective in settings supportive of shareholder rights enforcement. Using an international sample of VC contracts, our study finds broad support for these conjectures. It delineates theoretical and practical implications for how investors can best deploy their capital in different institutional settings whilst nurturing their relationships with entrepreneurs