Measuring Summer Dormancy of Perennial Grasses in Contrasting Environments

The summer dormancy trait has been shown to confer enhanced levels of survival to temperate perennial forage species over long periods of intense summer drought (Volaire and Norton 2006) and is therefore valuable in plant improvement. Normally found in species endemic to drier Mediterranean climates it is recommended that the trait be measured in the field under typical Mediterranean hot, dry summer conditions (Norton et al. 2008). However, this trait has potential utility in regions with summers that can receive substantial rainfall, but still experience extended periods of intense moisture deficit. Therefore, it is important to determine whether summer dormancy expression can be reliably measured in environments cooler and moister than those considered typically Mediterranean. This paper compares the measurement of summer dormancy across a range of three commercially important temperate perennial grass species when undertaken in typical Mediterranean summer conditions and in a cooler and wetter summer environment

Breaking the safety barrier : engineering new paradigms in safety design

Occupational health and safety legislation in Australia and internationally is based on the safe place concept and the hierarchy of control. A safe place is best achieved at the design stage and consequently the education of engineers in safety has been a priority. There have been notable efforts at the integration of safety with engineering studies, and this should be an ongoing objective, however extensive integration is likely to be difficult at least in the short term. The challenge was to develop a supplemental, innovative way to improve the ability of engineers to develop safe place solutions. The hypothesis was that training in creative thinking would achieve this aim. The hierarchy of control methodology shares a strong relationship with creative thinking. Safe place thinking challenges assumptions in the same way that creative thinking seeks to escape dominant paradigms. For this reason creative thinking seems a natural aid to the safe place approach. This study tested the effect on safety design of a creative thinking program; de Bono’s six thinking hats method. Given a recognition that groups other than engineers impact on workplace design, a range of subjects were included; engineering students, technology students, industry safety advisers, and government safety advisers. In response to safety case studies, subjects were required to generate solutions and to prioritize potential solutions. Subjects worked on a range of problems, some individually and some in teams of three. Results show that training in creative thinking improved the generation of solutions to safety problems. As the number of solutions increased, the average quality of ideas was maintained, therefore the increased number of solutions was accompanied by a similar increase in good quality safe place solutions. The results also showed in some instances the training improved the prioritization of solutions according to the safe place methodology. The effects were of a similar magnitude for individuals and teams. Creative thinking training was shown to be a useful way to enhance the generation of safe place solutions to safety problems. Given that creative thinking skills can theoretically be applied to any area of problem solving, the enhancement of these skills are likely to yield wider benefits. Furthermore the enhancement of creative thinking accords well with the current industrial mandates for improved innovation.Doctor of Philosoph

Initial force and desirable handle height range when pushing a trolley

Trolleys are used in many workplaces, often as a solution to the hazards of lifting and carrying. Guidelines are available to set limits on the force that can be reasonably applied for push and pull activities in a workplace setting. With a level floor, low friction and short movements, the force applied for acceleration when pushing a trolley is more significant than the sustained effort (however, many factors interact with the force and these must be considered together). This study determined the initial force applied to trolleys in a manufacturing setting, with a level floor and low rolling friction. Subjects were asked to move trolleys (weighing between 160 kg and 400 kg) a short distance in the way that they would normally do the work. Results showed a preferred grip height of 120-135 cm. The average results for applied force fell closely along a linear relationship. Future research could be conducted in an experimental setting and include more comprehensive trials with a greater number of subjects (including women).C

Moderate physical activity may prevent cartilage loss in women with knee osteoarthritis : data from the Osteoarthritis Initiative

All authors have completed the ICMJE uniform disclosure form at http://www.icmje.org/coi_disclosure.pdf and declare: data acquisition in this study was funded by the Osteoarthritis Initiative, a public–private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259;N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the Osteoarthritis Initiative study Investigators. Private funding partners of the OAI include Merck Research Laboratories, Novartis Pharmaceuticals Corporation, GlaxoSmithKline, and Pfizer, Inc. Private sector funding for the Osteoarthritis Initiative is managed by the Foundation for the National Institutes of Health. The image analysis in this study was partly funded by the FNIH OA Biomarkers Consortium, with grants, direct and in -kind contributions, provided by: AbbVie; Amgen Inc.; Arthritis Foundation; Bioiberica S.A.; DePuy Mitek, Inc.; Flexion Therapeutics, Inc.; GlaxoSmithKline; Merck KGaA; Rottapharm | Madaus; Sanofi; and Stryker. Other parts of funding were provided by a direct grant from Merck KGaA, by a contract with the University of Pittsburgh (Pivotal OAI MRI Analyses [POMA]: NIH/NHLBI Contract No. HHSN2682010000 21C), by a vendor contract from the OAI coordinating center at University of California, San Francisco (N01-AR-2-2258), and by an ancillary study to the OAI held by the Division of Rheumatology, Feinberg School of Medicine, Northwestern University (R01 AR52918). This research has also received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-ITN; KNEEMO) under grant agreement number 607510. AGC is supported by a National Health and Medical Research Council (NHMRC) of Australia Early Career Fellowship (Neil Hamilton Fairley Clinical Fellowship No.1121173). The sponsors were not involved in the design and conduct of this particular study, in the analysis and interpretation of the data, and in the preparation, review, or approval of the manuscript.Peer reviewedPostprin

Improving the Phosphorus Efficiency of Temperate Australian Pastures

Phosphorus (P) is a key input necessary for high production in many temperate, grass-legume pasture systems in Australia because the pastures are situated on P-deficient and moderate to highly P-sorbing soils. A consequence of P-sorption in these soils is that much more P must be applied as fertiliser than will be exported in animal products. The P balance efficiency (PBE=100*Pexport/Pinputs) of grazing enterprises (e.g. wool, meat, milk and live animal export) is about 10-30% and compares poorly with some other agricultural enterprises (e.g. 45-54% for grain production; McLaughlin et al. 1992; Weaver and Wong 2011). P accumulates in these soils when they are fertilised as a result of phosphate reactions with Ca and/or Al and Fe oxides, and P incorporation into resistant organic materials (McLaughlin et al. 2011). Some P in grazed fields is also accumulated in animal camps. The net rate of P accumulation in soil (and in grazed fields as a whole) is related to the concentration of plant-available P in the soil. Operating grazing systems at lower plant-available P levels should help to slow P accumulation and result in more effective use of P fertiliser (Simpson et al. 2010; Simpson et al. 2011). Because the P requirement of grass-legume pastures is usually set by the high P requirements of the legume (Hill et al. 2005), we commenced a study to quantify the P requirements of a range of legumes to determine whether productive, lower P-input grazing systems can be developed. We are also screening subterranean clover, the most widely used pasture legume in temperate Australia, for root traits related to P efficiency. Here we report early findings from the establishment year of a field experiment to determine the P requirement of several alternative temperate legumes

Effect of Metal Chelators on γ-Secretase Indicates That Calcium and Magnesium Ions Facilitate Cleavage of Alzheimer Amyloid Precursor Substrate

Gamma-secretase is involved in the production of Aβ amyloid peptides. It cleaves the transmembrane domain of the amyloid precursor protein (APP) at alternative sites to produce Aβ and the APP intracellular domain (AICD). Metal ions play an important role in Aβ aggregation and metabolism, thus metal chelators and ligands represent potential therapeutic agents for AD treatment. A direct effect of metal chelators on γ-secretase has not yet been investigated. The authors used an in vitro  γ-secretase assay consisting of cleavage of APP C100-3XFLAG by endogenous γ-secretase from rodent brains and human neuroblastoma SH-SY5Y, and detected AICD production by western blotting. Adding metalloprotease inhibitors to the reaction showed that clioquinol, phosphoramidon, and zinc metalloprotease inhibitors had no significant effect on γ-secretase activity. In contrast, phenanthroline, EDTA, and EGTA markedly decreased γ-secretase activity that could be restored by adding back calcium and magnesium ions. Mg2+ stabilized a 1,000 kDa presenilin 1 complex through blue native gel electrophoresis and size-exclusion chromatography. Data suggest that Ca2+ and Mg2+ stabilize γ-secretase and enhance its activity

Concepts of accident causation and their role in safe design among engineering students

Safe design is a strong theme at present in Australia. To ‘eliminate hazards at the design stage’ is one of the five national priorities set out by the National OHS Strategy. The Australian Safety and Compensation Council have recently released both a guideline for safe design and an engineering education package. Safe design is not only about engineering decisions. Engineers are however an important group. This paper reports on a survey to evaluate perceptions of student engineers on topics relevant to the advancement of safe design including perceptions of: control versus fatalism; accident causation; and perceptions of the role played by engineers